Genetic Neural Architecture Search for automatic assessment of human sperm images
Male infertility is a disease that affects approximately 7% of men. Sperm morphology analysis (SMA) is one of the main diagnosis methods for this problem. However, manual SMA is an inexact, subjective, non-reproducible, and hard to teach process. Therefore, in this paper, we introduce a novel automa...
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| Vydáno v: | Expert systems with applications Ročník 188; s. 115937 |
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| Hlavní autoři: | , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Elsevier Ltd
01.02.2022
Elsevier BV Elsevier |
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| ISSN: | 0957-4174, 1873-6793 |
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| Abstract | Male infertility is a disease that affects approximately 7% of men. Sperm morphology analysis (SMA) is one of the main diagnosis methods for this problem. However, manual SMA is an inexact, subjective, non-reproducible, and hard to teach process. Therefore, in this paper, we introduce a novel automatic SMA technique that is based on the neural architecture search algorithm, named Genetic Neural Architecture Search (GeNAS). For this purpose, we used a collection of images termed MHSMA dataset, which contains 1540 sperm images that have been collected from 235 patients with infertility problems. In detail, GeNAS consists of a special genetic algorithm that acts as a meta-controller which explores the constrained search space of plain convolutional neural network architectures. Every individual of this genetic algorithm is a convolutional neural network trained to predict morphological deformities in different segments of human sperm (head, vacuole, and acrosome). The fitness of each individual is calculated by a novel proposed method, named GeNAS Weighting Factor (GeNAS-WF). This technique is specially designed to evaluate the fitness of neural networks which, during their learning process, validation accuracy highly fluctuates. To speed up the algorithm, a hashing method is practiced to save each trained neural architecture fitness, so we could reuse them during fitness evaluation. In terms of running time and computational power, our proposed architecture search method is far more efficient than most of the other existing neural architecture search algorithms. Moreover, whereas most of the existing neural architecture search algorithms are designed to work well with well-prepared benchmark datasets, the overall paradigm of GeNAS is specially designed to address the challenges of real-world datasets, particularly shortage of data and class imbalance. In our experiments, the best neural architecture found by GeNAS has reached an accuracy of 91.66%, 77.33%, and 77.66% in the vacuole, head, and acrosome abnormality detection, respectively. In comparison to other proposed algorithms for MHSMA dataset, GeNAS achieved state-of-the-art results.
•A novel neural architecture search based on Genetic Algorithm.•A novel neural architecture encoding for exploration of search space.•A specific Crossover and Mutation operations for neural architecture search.•Work on imbalanced datasets, low resolution images, and non-stained sperms.•State-of-the-art accuracy & Real-time sperm morphological analysis. |
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| AbstractList | Male infertility is a disease that affects approximately 7% of men. Sperm morphology analysis (SMA) is one of the main diagnosis methods for this problem. However, manual SMA is an inexact, subjective, non-reproducible, and hard to teach process. Therefore, in this paper, we introduce a novel automatic SMA technique that is based on the neural architecture search algorithm, named Genetic Neural Architecture Search (GeNAS). For this purpose, we used a collection of images termed MHSMA dataset, which contains 1540 sperm images that have been collected from 235 patients with infertility problems. In detail, GeNAS consists of a special genetic algorithm that acts as a meta-controller which explores the constrained search space of plain convolutional neural network architectures. Every individual of this genetic algorithm is a convolutional neural network trained to predict morphological deformities in different segments of human sperm (head, vacuole, and acrosome). The fitness of each individual is calculated by a novel proposed method, named GeNAS Weighting Factor (GeNAS-WF). This technique is specially designed to evaluate the fitness of neural networks which, during their learning process, validation accuracy highly fluctuates. To speed up the algorithm, a hashing method is practiced to save each trained neural architecture fitness, so we could reuse them during fitness evaluation. In terms of running time and computational power, our proposed architecture search method is far more efficient than most of the other existing neural architecture search algorithms. Moreover, whereas most of the existing neural architecture search algorithms are designed to work well with well-prepared benchmark datasets, the overall paradigm of GeNAS is specially designed to address the challenges of real-world datasets, particularly shortage of data and class imbalance. In our experiments, the best neural architecture found by GeNAS has reached an accuracy of 91.66%, 77.33%, and 77.66% in the vacuole, head, and acrosome abnormality detection, respectively. In comparison to other proposed algorithms for MHSMA dataset, GeNAS achieved state-of-the-art results.
•A novel neural architecture search based on Genetic Algorithm.•A novel neural architecture encoding for exploration of search space.•A specific Crossover and Mutation operations for neural architecture search.•Work on imbalanced datasets, low resolution images, and non-stained sperms.•State-of-the-art accuracy & Real-time sperm morphological analysis. Male infertility is a disease that affects approximately 7% of men. Sperm morphology analysis (SMA) is one of the main diagnosis methods for this problem. However, manual SMA is an inexact, subjective, nonreproducible, and hard to teach process. Therefore, in this paper, we introduce a novel automatic SMA technique that is based on the neural architecture search algorithm, named Genetic Neural Architecture Search (GeNAS). For this purpose, we used a collection of images termed MHSMA dataset, which contains 1, 540 sperm images that have been collected from 235 patients with infertility problems. In detail, GeNAS consists of a special genetic algorithm that acts as a meta-controller which explores the constrained search space of plain convolutional neural network architectures. Every individual of this genetic algorithm is a convolutional neural network trained to predict morphological deformities in different segments of human sperm (head, vacuole, and acrosome). The fitness of each individual is calculated by a novel proposed method, named GeNAS Weighting Factor (GeNAS-WF). This technique is specially designed to evaluate the fitness of neural networks which, during their learning process, validation accuracy highly fluctuates. To speed up the algorithm, a hashing method is practiced to save each trained neural architecture fitness, so we could reuse them during fitness evaluation. In terms of running time and computational power, our proposed architecture search method is far more efficient than most of the other existing neural architecture search algorithms. Moreover, whereas most of the existing neural architecture search algorithms are designed to work well with well-prepared benchmark datasets, the overall paradigm of GeNAS is specially designed to address the challenges of real-world datasets, particularly shortage of data and class imbalance. In our experiments, the best neural architecture found by GeNAS has reached an accuracy of 91.66%, 77.33%, and 77.66% in the vacuole, head, and acrosome abnormality detection, respectively. In comparison to other proposed algorithms for MHSMA dataset, GeNAS achieved state-of-the-art results. Male infertility is a disease that affects approximately 7% of men. Sperm morphology analysis (SMA) is one of the main diagnosis methods for this problem. However, manual SMA is an inexact, subjective, non-reproducible, and hard to teach process. Therefore, in this paper, we introduce a novel automatic SMA technique that is based on the neural architecture search algorithm, named Genetic Neural Architecture Search (GeNAS). For this purpose, we used a collection of images termed MHSMA dataset, which contains 1540 sperm images that have been collected from 235 patients with infertility problems. In detail, GeNAS consists of a special genetic algorithm that acts as a meta-controller which explores the constrained search space of plain convolutional neural network architectures. Every individual of this genetic algorithm is a convolutional neural network trained to predict morphological deformities in different segments of human sperm (head, vacuole, and acrosome). The fitness of each individual is calculated by a novel proposed method, named GeNAS Weighting Factor (GeNAS-WF). This technique is specially designed to evaluate the fitness of neural networks which, during their learning process, validation accuracy highly fluctuates. To speed up the algorithm, a hashing method is practiced to save each trained neural architecture fitness, so we could reuse them during fitness evaluation. In terms of running time and computational power, our proposed architecture search method is far more efficient than most of the other existing neural architecture search algorithms. Moreover, whereas most of the existing neural architecture search algorithms are designed to work well with well-prepared benchmark datasets, the overall paradigm of GeNAS is specially designed to address the challenges of real-world datasets, particularly shortage of data and class imbalance. In our experiments, the best neural architecture found by GeNAS has reached an accuracy of 91.66%, 77.33%, and 77.66% in the vacuole, head, and acrosome abnormality detection, respectively. In comparison to other proposed algorithms for MHSMA dataset, GeNAS achieved state-of-the-art results. |
| ArticleNumber | 115937 |
| Author | Nasr, Alexis Mirroshandel, Seyed Abolghasem Miahi, Erfan |
| Author_xml | – sequence: 1 givenname: Erfan surname: Miahi fullname: Miahi, Erfan email: mhi.erfan1@gmail.com organization: Department of Computer Engineering, University of Guilan, Rasht, Iran – sequence: 2 givenname: Seyed Abolghasem orcidid: 0000-0001-8853-9112 surname: Mirroshandel fullname: Mirroshandel, Seyed Abolghasem email: mirroshandel@guilan.ac.ir organization: Department of Computer Engineering, University of Guilan, Rasht, Iran – sequence: 3 givenname: Alexis surname: Nasr fullname: Nasr, Alexis email: alexis.nasr@univ-amu.fr organization: Laboratoire dÍnformatique et Systemes, Aix Marseille Université, Marseille, France |
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| CitedBy_id | crossref_primary_10_1016_j_bspc_2024_106152 crossref_primary_10_3390_math11030515 crossref_primary_10_1016_j_compmedimag_2024_102441 crossref_primary_10_1080_21681163_2024_2347978 crossref_primary_10_1109_TAI_2024_3477457 crossref_primary_10_3390_diagnostics13061100 crossref_primary_10_3390_electronics14091820 crossref_primary_10_1016_j_engfailanal_2024_108426 crossref_primary_10_32604_cmes_2023_030391 crossref_primary_10_3390_healthcare12070781 crossref_primary_10_1111_rda_70024 crossref_primary_10_3390_genes14020451 crossref_primary_10_1016_j_asoc_2023_110412 crossref_primary_10_1145_3603704 crossref_primary_10_1016_j_imu_2024_101565 crossref_primary_10_1016_j_neucom_2024_127664 crossref_primary_10_1016_j_apm_2023_10_025 |
| Cites_doi | 10.1016/j.anireprosci.2013.04.002 10.1109/JPROC.2015.2494218 10.1016/j.compbiomed.2019.04.030 10.1109/5.726791 10.1016/j.cmpb.2015.08.013 10.1016/j.bspc.2017.11.009 10.26415/2572-004X-vol2iss4p301-307 10.5120/743-1050 10.1155/2018/7068349 10.1038/s42003-019-0491-6 10.1109/CVPR.2009.5206848 10.1016/j.compbiomed.2017.03.004 10.1016/j.theriogenology.2011.10.039 10.1609/aaai.v33i01.33014780 10.1002/j.1939-4640.2004.tb02807.x 10.1016/j.compbiomed.2019.103342 10.1038/s41591-018-0316-z 10.1109/COGANN.1992.273950 10.1016/j.compbiomed.2008.01.005 10.1016/j.contraception.2005.05.007 10.4236/jbise.2012.57049 10.1109/TSMC.1979.4310076 10.1016/j.fertnstert.2007.08.071 10.1162/106365602320169811 10.1109/CVPR.2018.00257 10.1002/for.3980040103 10.1007/978-3-030-05318-5_3 10.1093/humrep/deq075 10.1016/j.cmpb.2014.06.018 |
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| Keywords | Deep learning Neural architecture search Human sperm morphometry Genetic algorithm Infertility Human Sperm Morphometry Neural Architecture Search Deep Learning Genetic Algorithm |
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| Snippet | Male infertility is a disease that affects approximately 7% of men. Sperm morphology analysis (SMA) is one of the main diagnosis methods for this problem.... |
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| SubjectTerms | Artificial Intelligence Artificial neural networks Bioinformatics Computer architecture Computer Science Datasets Deep learning Evaluation Fitness Genetic algorithm Genetic algorithms Human sperm morphometry Infertility Machine learning Medical imaging Morphology Neural architecture search Neural networks Search algorithms Search methods Sperm |
| Title | Genetic Neural Architecture Search for automatic assessment of human sperm images |
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