Role of Pyroptosis in Cardiovascular Diseases and its Therapeutic Implications

Pyroptotic cell death or pyroptosis is characterized by caspase-1-dependent formation of plasma membrane pores, leading to the release of pro-inflammatory cytokines and cell lysis. Pyroptosis tightly controls the inflammatory responses and coordinates antimicrobial host defenses by releasing pro-inf...

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Bibliographic Details
Published in:	International journal of biological sciences Vol. 15; no. 7; pp. 1345 - 1357
Main Authors:	Zeng, Cheng, Wang, Renqing, Tan, Hongmei
Format:	Journal Article
Language:	English
Published:	Australia Ivyspring International Publisher Pty Ltd 01.01.2019 Ivyspring International Publisher
Subjects:	Activation Animals Autophagy Cardiovascular diseases Cardiovascular Diseases - metabolism Cardiovascular Diseases - therapy Carrier Proteins - metabolism Caspase Caspase 1 - metabolism Caspase-1 Cell death Cytokines Diabetes mellitus Diabetic Cardiomyopathies - metabolism Health risks Heart Failure - metabolism Humans Hyperhomocysteinemia Hyperlipidemia Hypertension Inflammasomes Inflammasomes - metabolism Inflammation Interleukin 18 Interleukins - metabolism Lysis Macrophages - metabolism Myocarditis - metabolism Myocarditis - virology NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Pathogenesis Pyroptosis Review Risk analysis Risk Factors pyroptosis NLRP3 cardiovascular diseases inflammation caspase-1 inflammasome
ISSN:	1449-2288, 1449-2288
Online Access:	Get full text
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