Minocycline rescues decrease in neurogenesis, increase in microglia cytokines and deficits in sensorimotor gating in an animal model of schizophrenia

Adult neurogenesis in the hippocampus is impaired in schizophrenic patients and in an animal model of schizophrenia. Amongst a plethora of regulators, the immune system has been shown repeatedly to strongly modulate neurogenesis under physiological and pathological conditions. It is well accepted, t...

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Vydáno v:	Brain, behavior, and immunity Ročník 38; s. 175 - 184
Hlavní autoři:	Mattei, Daniele, Djodari-Irani, Anaïs, Hadar, Ravit, Pelz, Andreas, de Cossío, Lourdes Fernandez, Goetz, Thomas, Matyash, Marina, Kettenmann, Helmut, Winter, Christine, Wolf, Susanne A.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier Inc 01.05.2014
Témata:	Allergy and Immunology Animal model Animals Anti-Bacterial Agents - pharmacology Brain - drug effects Cytokines Cytokines - biosynthesis Disease Models, Animal Male Microglia Microglia - drug effects Microglia - immunology Minocycline Minocycline - pharmacology Neurogenesis Neurogenesis - drug effects Neuroinflammation Poly I-C - pharmacology Poly I:C Psychiatry Rats Rats, Wistar Schizophrenia Schizophrenia - immunology Schizophrenia - metabolism Schizophrenia - physiopathology Sensorimotor gating Sensory Gating - drug effects Sensorimotor gating Animal model Cytokines Schizophrenia Minocycline Neuroinflammation Poly I:C Neurogenesis Microglia
ISSN:	0889-1591, 1090-2139, 1090-2139
On-line přístup:	Získat plný text
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