M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages

M2-polarized, pro-tumoral tumor-associated macrophages (TAMs) express the interleukin-4 receptor (IL4R) at higher levels compared with M1-polarized, anti-tumoral macrophages. In this study, we harnessed M1 macrophage-derived exosomes engineered to foster M1 polarization and target IL4R for the inhib...

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Vydáno v:	Biomaterials Ročník 278; s. 121137
Hlavní autoři:	Gunassekaran, Gowri Rangaswamy, Poongkavithai Vadevoo, Sri Murugan, Baek, Moon-Chang, Lee, Byungheon
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier Ltd 01.11.2021
Témata:	biocompatible materials Cellular Reprogramming Exosome Exosomes fluorescence Humans immunity immunotherapy interleukin-4 Interleukin-4 receptor Interleukin-4 Receptor alpha Subunit liver M1 macrophage M2 macrophage Macrophages miR-511–3p neoplasms Neoplasms - therapy NF-κB p50 Receptors, Interleukin-4 Tumor-associated macrophage Tumor-Associated Macrophages M2 macrophage miR-511–3p Exosome M1 macrophage Interleukin-4 receptor Tumor-associated macrophage NF-κB p50
ISSN:	0142-9612, 1878-5905, 1878-5905
On-line přístup:	Získat plný text
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