M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages

M2-polarized, pro-tumoral tumor-associated macrophages (TAMs) express the interleukin-4 receptor (IL4R) at higher levels compared with M1-polarized, anti-tumoral macrophages. In this study, we harnessed M1 macrophage-derived exosomes engineered to foster M1 polarization and target IL4R for the inhib...

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Bibliographic Details
Published in:	Biomaterials Vol. 278; p. 121137
Main Authors:	Gunassekaran, Gowri Rangaswamy, Poongkavithai Vadevoo, Sri Murugan, Baek, Moon-Chang, Lee, Byungheon
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.11.2021
Subjects:	biocompatible materials Cellular Reprogramming Exosome Exosomes fluorescence Humans immunity immunotherapy interleukin-4 Interleukin-4 receptor Interleukin-4 Receptor alpha Subunit liver M1 macrophage M2 macrophage Macrophages miR-511–3p neoplasms Neoplasms - therapy NF-κB p50 Receptors, Interleukin-4 Tumor-associated macrophage Tumor-Associated Macrophages M2 macrophage miR-511–3p Exosome M1 macrophage Interleukin-4 receptor Tumor-associated macrophage NF-κB p50
ISSN:	0142-9612, 1878-5905, 1878-5905
Online Access:	Get full text
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