High-density lipoprotein from subjects with coronary artery disease promotes macrophage foam cell formation: role of scavenger receptor CD36 and ERK/MAPK signaling

Although high-density lipoprotein is atheroprotective, it can become dysfunctional in chronic inflammatory conditions and increase cardiovascular risk. We previously demonstrated that HDL from subjects with documented coronary artery disease is dysfunctional and is pro-oxidant/proinflammatory in mac...

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Bibliographic Details
Published in:	Molecular and cellular biochemistry Vol. 427; no. 1-2; pp. 23 - 34
Main Authors:	Sini, S., Deepa, D., Harikrishnan, S., Jayakumari, N.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.03.2017 Springer Springer Nature B.V
Subjects:	Accumulation Adult Antigens, Neoplasm - biosynthesis ATP Binding Cassette Transporter, Sub-Family G, Member 1 - biosynthesis Biochemistry Biomedical and Life Sciences Cardiology Cardiovascular disease Cholesterol Coronary Artery Disease - blood Coronary Artery Disease - pathology Coronary heart disease Female Foam Cells - metabolism Foam Cells - pathology Gene Expression Regulation - drug effects Health risks Humans Inflammation Leukocytes Life Sciences Lipids Lipoproteins Lipoproteins, HDL - blood Lipoproteins, HDL - pharmacology Macrophages Male MAP Kinase Signaling System - drug effects Matrix Metalloproteinase 9 - biosynthesis Medical Biochemistry Middle Aged NF-E2-Related Factor 2 - metabolism Oncology Oxidative stress Oxidizing agents PPAR gamma - metabolism Scavenger Receptors, Class B - biosynthesis Signal transduction Tetraspanins - biosynthesis Tumor Necrosis Factor-alpha - metabolism MAPK pathway Foam cell CD 36 Proinflammatory HDL
ISSN:	0300-8177, 1573-4919
Online Access:	Get full text
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