Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo

High-mobility group box 1 (HMGB-1) has been reported as a "late" proinflammatory mediator in sepsis. In vitro data have shown that HMGB-1 can induce activation of intracellular signaling pathways via interaction with at least three pattern recognition receptors: Toll-like receptor (TLR) 2,...

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Bibliographic Details
Published in:	Shock (Augusta, Ga.) Vol. 31; no. 3; p. 280
Main Authors:	van Zoelen, Marieke A D, Yang, Huan, Florquin, Sandrine, Meijers, Joost C M, Akira, Shizuo, Arnold, Bernd, Nawroth, Peter P, Bierhaus, Angelika, Tracey, Kevin J, van der Poll, Tom
Format:	Journal Article
Language:	English
Published:	United States 01.03.2009
Subjects:	Animals Antithrombin III - genetics Antithrombin III - metabolism Cytokines - genetics Cytokines - metabolism Female HMGB1 Protein - toxicity Inflammation - chemically induced Inflammation - genetics Inflammation - metabolism Inflammation - mortality Inflammation Mediators - toxicity Male Mice Mice, Knockout Neutrophils - metabolism Neutrophils - pathology Peptide Hydrolases - genetics Peptide Hydrolases - metabolism Receptor for Advanced Glycation End Products Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Time Factors Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism
ISSN:	1540-0514, 1540-0514
Online Access:	Get more information
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