In vitro and in vivo protection against the highly pathogenic H5N1 influenza virus by an antisense phosphorothioate oligonucleotide

Current vaccination strategies and antiviral drugs only provide limited protection against influenza virus infection. In this study, we investigated the use of a novel antisense oligonucleotide (named IV-AS), which is specific for the 5'-terminal conserved sequence found in all eight viral RNA...

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Vydané v:	Antiviral therapy Ročník 13; číslo 1; s. 109
Hlavní autori:	Duan, Ming, Zhou, Zhe, Lin, Ru-Xian, Yang, Jing, Xia, Xian-Zhu, Wang, Sheng-Qi
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 2008
Predmet:	Animals Cell Line Cytopathogenic Effect, Viral Dogs Dose-Response Relationship, Drug Influenza A Virus, H5N1 Subtype - immunology Lung - pathology Lung - virology Mice Mice, Inbred BALB C Oligonucleotides, Antisense - adverse effects Oligonucleotides, Antisense - immunology Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - virology Phosphorothioate Oligonucleotides - adverse effects Phosphorothioate Oligonucleotides - immunology Specific Pathogen-Free Organisms Time Factors
ISSN:	1359-6535
On-line prístup:	Zistit podrobnosti o prístupe
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