TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer

Tumor necrosis factor (TNF) is crucial for innate immunity, but deregulated TNF signaling also plays an eminent role in the pathogenesis of many chronic inflammatory diseases and cancer‐related inflammation. The signals that mediate both the beneficial and the harmful effects of TNF are initiated wh...

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Published in:	Immunological reviews Vol. 244; no. 1; pp. 9 - 28
Main Author:	Walczak, Henning
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01.11.2011
Subjects:	Apoptosis - genetics Apoptosis - immunology apoptosis/autophagy Autophagy - genetics Autophagy - immunology cytokines cytotoxicity Humans Immunity, Innate Inflammation - genetics Inflammation - immunology Inflammation - metabolism Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism Protein Binding - genetics Receptors, Tumor Necrosis Factor, Type I - genetics Receptors, Tumor Necrosis Factor, Type I - immunology Receptors, Tumor Necrosis Factor, Type I - metabolism Receptors, Tumor Necrosis Factor, Type II - genetics Receptors, Tumor Necrosis Factor, Type II - immunology Receptors, Tumor Necrosis Factor, Type II - metabolism signal transduction Signal Transduction - genetics Signal Transduction - immunology signaling proteins Transcriptional Activation - immunology Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism Ubiquitin - genetics Ubiquitin - immunology Ubiquitin - metabolism Ubiquitination - genetics Ubiquitination - immunology
ISSN:	0105-2896, 1600-065X, 1600-065X
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Abstract	Tumor necrosis factor (TNF) is crucial for innate immunity, but deregulated TNF signaling also plays an eminent role in the pathogenesis of many chronic inflammatory diseases and cancer‐related inflammation. The signals that mediate both the beneficial and the harmful effects of TNF are initiated when TNF binds to its receptors on the surface of target cells. TNF receptor 1 (TNFR1) is ubiquitously expressed, whereas TNFR2 is mainly expressed on lymphocytes and endothelial cells. This review focuses on the molecular and physiological consequences of the interaction of TNF with TNFR1. The different outcomes of TNF signaling originate at the apical signaling complex that forms when TNF binds to TNFR1, the TNFR1 signaling complex (TNF‐RSC). By integrating recently gained insight on the functional importance of the presence of different types of ubiquitination in the TNF‐RSC, including linear ubiquitin linkages generated by the linear ubiquitin chain assembly complex (LUBAC), with the equally recent elucidation of the mode in which ubiquitin‐binding domains interact with specific di‐ubiquitin linkages, this review develops a new concept for the way the concerted action of different ubiquitination events enables the TNF‐RSC to generate its signaling output in a spatio‐temporally controlled manner. Finally, it will be explained how these new findings and the emerging concept of differential ubiquitination governing the TNF‐RSC may impact future research on the molecular mechanism of TNF signaling and the function of this cytokine in normal physiology, chronic inflammation, and cancer.
AbstractList	Tumor necrosis factor (TNF) is crucial for innate immunity, but deregulated TNF signaling also plays an eminent role in the pathogenesis of many chronic inflammatory diseases and cancer-related inflammation. The signals that mediate both the beneficial and the harmful effects of TNF are initiated when TNF binds to its receptors on the surface of target cells. TNF receptor 1 (TNFR1) is ubiquitously expressed, whereas TNFR2 is mainly expressed on lymphocytes and endothelial cells. This review focuses on the molecular and physiological consequences of the interaction of TNF with TNFR1. The different outcomes of TNF signaling originate at the apical signaling complex that forms when TNF binds to TNFR1, the TNFR1 signaling complex (TNF-RSC). By integrating recently gained insight on the functional importance of the presence of different types of ubiquitination in the TNF-RSC, including linear ubiquitin linkages generated by the linear ubiquitin chain assembly complex (LUBAC), with the equally recent elucidation of the mode in which ubiquitin-binding domains interact with specific di-ubiquitin linkages, this review develops a new concept for the way the concerted action of different ubiquitination events enables the TNF-RSC to generate its signaling output in a spatio-temporally controlled manner. Finally, it will be explained how these new findings and the emerging concept of differential ubiquitination governing the TNF-RSC may impact future research on the molecular mechanism of TNF signaling and the function of this cytokine in normal physiology, chronic inflammation, and cancer.Tumor necrosis factor (TNF) is crucial for innate immunity, but deregulated TNF signaling also plays an eminent role in the pathogenesis of many chronic inflammatory diseases and cancer-related inflammation. The signals that mediate both the beneficial and the harmful effects of TNF are initiated when TNF binds to its receptors on the surface of target cells. TNF receptor 1 (TNFR1) is ubiquitously expressed, whereas TNFR2 is mainly expressed on lymphocytes and endothelial cells. This review focuses on the molecular and physiological consequences of the interaction of TNF with TNFR1. The different outcomes of TNF signaling originate at the apical signaling complex that forms when TNF binds to TNFR1, the TNFR1 signaling complex (TNF-RSC). By integrating recently gained insight on the functional importance of the presence of different types of ubiquitination in the TNF-RSC, including linear ubiquitin linkages generated by the linear ubiquitin chain assembly complex (LUBAC), with the equally recent elucidation of the mode in which ubiquitin-binding domains interact with specific di-ubiquitin linkages, this review develops a new concept for the way the concerted action of different ubiquitination events enables the TNF-RSC to generate its signaling output in a spatio-temporally controlled manner. Finally, it will be explained how these new findings and the emerging concept of differential ubiquitination governing the TNF-RSC may impact future research on the molecular mechanism of TNF signaling and the function of this cytokine in normal physiology, chronic inflammation, and cancer. Tumor necrosis factor (TNF) is crucial for innate immunity, but deregulated TNF signaling also plays an eminent role in the pathogenesis of many chronic inflammatory diseases and cancer‐related inflammation. The signals that mediate both the beneficial and the harmful effects of TNF are initiated when TNF binds to its receptors on the surface of target cells. TNF receptor 1 (TNFR1) is ubiquitously expressed, whereas TNFR2 is mainly expressed on lymphocytes and endothelial cells. This review focuses on the molecular and physiological consequences of the interaction of TNF with TNFR1. The different outcomes of TNF signaling originate at the apical signaling complex that forms when TNF binds to TNFR1, the TNFR1 signaling complex (TNF‐RSC). By integrating recently gained insight on the functional importance of the presence of different types of ubiquitination in the TNF‐RSC, including linear ubiquitin linkages generated by the linear ubiquitin chain assembly complex (LUBAC), with the equally recent elucidation of the mode in which ubiquitin‐binding domains interact with specific di‐ubiquitin linkages, this review develops a new concept for the way the concerted action of different ubiquitination events enables the TNF‐RSC to generate its signaling output in a spatio‐temporally controlled manner. Finally, it will be explained how these new findings and the emerging concept of differential ubiquitination governing the TNF‐RSC may impact future research on the molecular mechanism of TNF signaling and the function of this cytokine in normal physiology, chronic inflammation, and cancer.
Author	Walczak, Henning
Author_xml	– sequence: 1 givenname: Henning surname: Walczak fullname: Walczak, Henning organization: Tumour Immunology Unit, Division of Immunology and Inflammation, Department of Medicine, Imperial College London, London, UK
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PublicationCentury	2000
PublicationDate	November 2011
PublicationDateYYYYMMDD	2011-11-01
PublicationDate_xml	– month: 11 year: 2011 text: November 2011
PublicationDecade	2010
PublicationPlace	Oxford, UK
PublicationPlace_xml	– name: Oxford, UK – name: England
PublicationTitle	Immunological reviews
PublicationTitleAlternate	Immunol Rev
PublicationYear	2011
Publisher	Blackwell Publishing Ltd
Publisher_xml	– name: Blackwell Publishing Ltd
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Snippet	Tumor necrosis factor (TNF) is crucial for innate immunity, but deregulated TNF signaling also plays an eminent role in the pathogenesis of many chronic...
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SubjectTerms	Apoptosis - genetics Apoptosis - immunology apoptosis/autophagy Autophagy - genetics Autophagy - immunology cytokines cytotoxicity Humans Immunity, Innate Inflammation - genetics Inflammation - immunology Inflammation - metabolism Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism Protein Binding - genetics Receptors, Tumor Necrosis Factor, Type I - genetics Receptors, Tumor Necrosis Factor, Type I - immunology Receptors, Tumor Necrosis Factor, Type I - metabolism Receptors, Tumor Necrosis Factor, Type II - genetics Receptors, Tumor Necrosis Factor, Type II - immunology Receptors, Tumor Necrosis Factor, Type II - metabolism signal transduction Signal Transduction - genetics Signal Transduction - immunology signaling proteins Transcriptional Activation - immunology Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism Ubiquitin - genetics Ubiquitin - immunology Ubiquitin - metabolism Ubiquitination - genetics Ubiquitination - immunology
Title	TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer
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Volume	244
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