Cardiovascular Importance of the MicroRNA-23/27/24 Family

Please cite this paper as: Bang C, Fiedler J, Thum T. Cardiovascular importance of the microRNA‐23/27/24 family. Microcirculation19: 208–214, 2012. MicroRNAs (miRNAs) are a class of highly conserved, noncoding short RNA molecules that regulate gene expression on the post‐transcriptional level. MiRNA...

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Published in:Microcirculation (New York, N.Y. 1994) Vol. 19; no. 3; pp. 208 - 214
Main Authors: BANG, CLAUDIA, FIEDLER, JAN, THUM, THOMAS
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Publishing Ltd 01.04.2012
Subjects:
angiogenesis
Animals
cardiovascular diseases
Cardiovascular Diseases - genetics
Cardiovascular Diseases - therapy
Cardiovascular Physiological Phenomena - genetics
Endothelial Cells - cytology
Endothelial Cells - physiology
Humans
Mice
microRNAs
MicroRNAs - genetics
MicroRNAs - physiology
Multigene Family
Neovascularization, Physiologic - genetics
ISSN:1073-9688, 1549-8719, 1549-8719
Online Access:Get full text
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Summary:Please cite this paper as: Bang C, Fiedler J, Thum T. Cardiovascular importance of the microRNA‐23/27/24 family. Microcirculation19: 208–214, 2012. MicroRNAs (miRNAs) are a class of highly conserved, noncoding short RNA molecules that regulate gene expression on the post‐transcriptional level. MiRNAs are involved in a variety of processes such as proliferation, differentiation, and apoptosis. Deregulated expression of miRNAs has been linked to the development of diseases including cardiovascular disorders. Recently, the miR‐23/27/24 cluster has been shown to be involved in angiogenesis and endothelial apoptosis in cardiac ischemia and retinal vascular development. In the present review, we summarize and discuss the role and importance of the miRNA‐23/27/24 cluster during cardiovascular angiogenesis. Moreover, we illustrate a novel therapeutic application of the miRNA‐23/27/24 cluster in vascular disorders and ischemic heart disease.
Bibliography:istex:0F09FEEA39C0555461857BF2A95504B2848BE2FC
ark:/67375/WNG-CRWTCWJD-5
ArticleID:MICC153
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1073-9688
1549-8719
1549-8719
DOI:10.1111/j.1549-8719.2011.00153.x