The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells

Recent studies have indicated that activated protein C (APC) may exert its cytoprotective and anti-inflammatory activities through the endothelial protein C receptor (EPCR)-dependent cleavage of protease-activated receptor 1 (PAR-1) on vascular endothelial cells. Noting that (1) the activation of pr...

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Bibliographic Details
Published in:	Blood Vol. 110; no. 12; p. 3909
Main Authors:	Bae, Jong-Sup, Yang, Likui, Manithody, Chandrashekhara, Rezaie, Alireza R
Format:	Journal Article
Language:	English
Published:	United States 01.12.2007
Subjects:	Antigens, CD - metabolism Caveolin 1 - metabolism Cell Line Cell Membrane Permeability - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Endothelial Protein C Receptor GTP-Binding Protein alpha Subunits, Gi-Go - metabolism Hemostatics - metabolism Hemostatics - pharmacology Humans Inflammation - metabolism Inflammation - pathology Ligands Membrane Microdomains - metabolism Membrane Microdomains - pathology Protein C - metabolism Protein C - pharmacology Receptor, PAR-1 - metabolism Receptors, Cell Surface - metabolism Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Signal Transduction - drug effects Thrombin - metabolism Thrombin - pharmacology
ISSN:	0006-4971
Online Access:	Get more information
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