Marburg virus VP40 antagonizes interferon signaling in a species-specific manner

Marburgviruses are zoonotic pathogens that cause lethal hemorrhagic fever in humans and nonhuman primates. However, they do not cause lethal disease in immunocompetent mice unless they are adapted to this species. The adaptation process can therefore provide insight into the specific virus-host inte...

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Vydané v:	Journal of virology Ročník 85; číslo 9; s. 4309
Hlavní autori:	Valmas, Charalampos, Basler, Christopher F
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.05.2011
Predmet:	Animals Cell Line Humans Interferon-alpha - antagonists & inhibitors Interferon-beta - antagonists & inhibitors Interferon-gamma - antagonists & inhibitors Janus Kinase 1 - metabolism Marburgvirus - pathogenicity Mice Phosphorylation Signal Transduction STAT1 Transcription Factor - metabolism STAT2 Transcription Factor - metabolism Viral Matrix Proteins - immunology Viral Matrix Proteins - metabolism
ISSN:	1098-5514, 1098-5514
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