Marburg virus VP40 antagonizes interferon signaling in a species-specific manner

Marburgviruses are zoonotic pathogens that cause lethal hemorrhagic fever in humans and nonhuman primates. However, they do not cause lethal disease in immunocompetent mice unless they are adapted to this species. The adaptation process can therefore provide insight into the specific virus-host inte...

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Bibliographic Details

Published in:	Journal of virology Vol. 85; no. 9; p. 4309
Main Authors:	Valmas, Charalampos, Basler, Christopher F
Format:	Journal Article
Language:	English
Published:	United States 01.05.2011
Subjects:	Animals Cell Line Humans Interferon-alpha - antagonists & inhibitors Interferon-beta - antagonists & inhibitors Interferon-gamma - antagonists & inhibitors Janus Kinase 1 - metabolism Marburgvirus - pathogenicity Mice Phosphorylation Signal Transduction STAT1 Transcription Factor - metabolism STAT2 Transcription Factor - metabolism Viral Matrix Proteins - immunology Viral Matrix Proteins - metabolism
ISSN:	1098-5514, 1098-5514
Online Access:	Get more information
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