Characterization of the Candiru antigenic complex (Bunyaviridae: Phlebovirus), a highly diverse and reassorting group of viruses affecting humans in tropical America

The genus Phlebovirus of the family Bunyaviridae consists of approximately 70 named viruses, currently assigned to nine serocomplexes (species) based on antigenic similarities. Sixteen other named viruses that show little serologic relationship to the nine recognized groups are also classified as te...

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Published in:Journal of virology Vol. 85; no. 8; p. 3811
Main Authors: Palacios, Gustavo, Tesh, Robert, Travassos da Rosa, Amelia, Savji, Nazir, Sze, Wilson, Jain, Komal, Serge, Robert, Guzman, Hilda, Guevara, Carolina, Nunes, Marcio R T, Nunes-Neto, Joaquim P, Kochel, Tadeusz, Hutchison, Stephen, Vasconcelos, Pedro F C, Lipkin, W Ian
Format: Journal Article
Language:English
Published: United States 01.04.2011
Subjects:
Americas
Cluster Analysis
Genetic Variation
Genome, Viral
Humans
Molecular Sequence Data
Phlebovirus - classification
Phlebovirus - genetics
Phlebovirus - isolation & purification
Phylogeny
Reassortant Viruses - genetics
RNA, Viral - genetics
Sequence Analysis, DNA
Serotyping
Tropical Climate
Americas
ISSN:1098-5514, 1098-5514
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Abstract The genus Phlebovirus of the family Bunyaviridae consists of approximately 70 named viruses, currently assigned to nine serocomplexes (species) based on antigenic similarities. Sixteen other named viruses that show little serologic relationship to the nine recognized groups are also classified as tentative species in the genus. In an effort to develop a more precise classification system for phleboviruses, we are attempting to sequence most of the named viruses in the genus with the goal of clarifying their phylogenetic relationships. In this report, we describe the serologic and phylogenetic relationships of 13 viruses that were found to be members of the Candiru serocomplex; 6 of them cause disease in humans. Analysis of full genome sequences revealed branching inconsistencies that suggest five reassortment events, all involving the M segment, and thus appear to be natural reassortants. This high rate of reassortment illustrates the inaccuracy of a classification system based solely on antigenic relationships.
AbstractList The genus Phlebovirus of the family Bunyaviridae consists of approximately 70 named viruses, currently assigned to nine serocomplexes (species) based on antigenic similarities. Sixteen other named viruses that show little serologic relationship to the nine recognized groups are also classified as tentative species in the genus. In an effort to develop a more precise classification system for phleboviruses, we are attempting to sequence most of the named viruses in the genus with the goal of clarifying their phylogenetic relationships. In this report, we describe the serologic and phylogenetic relationships of 13 viruses that were found to be members of the Candiru serocomplex; 6 of them cause disease in humans. Analysis of full genome sequences revealed branching inconsistencies that suggest five reassortment events, all involving the M segment, and thus appear to be natural reassortants. This high rate of reassortment illustrates the inaccuracy of a classification system based solely on antigenic relationships.The genus Phlebovirus of the family Bunyaviridae consists of approximately 70 named viruses, currently assigned to nine serocomplexes (species) based on antigenic similarities. Sixteen other named viruses that show little serologic relationship to the nine recognized groups are also classified as tentative species in the genus. In an effort to develop a more precise classification system for phleboviruses, we are attempting to sequence most of the named viruses in the genus with the goal of clarifying their phylogenetic relationships. In this report, we describe the serologic and phylogenetic relationships of 13 viruses that were found to be members of the Candiru serocomplex; 6 of them cause disease in humans. Analysis of full genome sequences revealed branching inconsistencies that suggest five reassortment events, all involving the M segment, and thus appear to be natural reassortants. This high rate of reassortment illustrates the inaccuracy of a classification system based solely on antigenic relationships.
The genus Phlebovirus of the family Bunyaviridae consists of approximately 70 named viruses, currently assigned to nine serocomplexes (species) based on antigenic similarities. Sixteen other named viruses that show little serologic relationship to the nine recognized groups are also classified as tentative species in the genus. In an effort to develop a more precise classification system for phleboviruses, we are attempting to sequence most of the named viruses in the genus with the goal of clarifying their phylogenetic relationships. In this report, we describe the serologic and phylogenetic relationships of 13 viruses that were found to be members of the Candiru serocomplex; 6 of them cause disease in humans. Analysis of full genome sequences revealed branching inconsistencies that suggest five reassortment events, all involving the M segment, and thus appear to be natural reassortants. This high rate of reassortment illustrates the inaccuracy of a classification system based solely on antigenic relationships.
Author Jain, Komal
Kochel, Tadeusz
Lipkin, W Ian
Nunes, Marcio R T
Hutchison, Stephen
Savji, Nazir
Guzman, Hilda
Nunes-Neto, Joaquim P
Vasconcelos, Pedro F C
Travassos da Rosa, Amelia
Sze, Wilson
Guevara, Carolina
Serge, Robert
Palacios, Gustavo
Tesh, Robert
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  organization: Center for Infection and Immunity, Mailman School of Public Health, Columbia University, 722 West 168th St., Rm. 1709, New York, NY 10032, USA. gp2050@columbia.edu
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Snippet The genus Phlebovirus of the family Bunyaviridae consists of approximately 70 named viruses, currently assigned to nine serocomplexes (species) based on...
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SubjectTerms Americas
Cluster Analysis
Genetic Variation
Genome, Viral
Humans
Molecular Sequence Data
Phlebovirus - classification
Phlebovirus - genetics
Phlebovirus - isolation & purification
Phylogeny
Reassortant Viruses - genetics
RNA, Viral - genetics
Sequence Analysis, DNA
Serotyping
Tropical Climate
Title Characterization of the Candiru antigenic complex (Bunyaviridae: Phlebovirus), a highly diverse and reassorting group of viruses affecting humans in tropical America
URI https://www.ncbi.nlm.nih.gov/pubmed/21289119
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