Protective Effects of Adeno-associated Virus Mediated Brain-derived Neurotrophic Factor Expression on Retinal Ganglion Cells in Diabetic Rats

Adeno-associated virus vector plasmid carrying the expression cassette of brain-derived neurotrophic factor (BDNF), pAAV-BDNF, was constructed and packaged into recombinant adeno-associated virus (rAAV-BDNF). The rAAV-BDNF was intravitreally injected into streptzotocin (STZ)-induced diabetic Sprague...

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Veröffentlicht in:	Cellular and molecular neurobiology Jg. 32; H. 3; S. 467 - 475
Hauptverfasser:	Gong, Yan, Chang, Zhan-Ping, Ren, Ruo-Tong, Wei, Shi-hui, Zhou, Huan-Fen, Chen, Xiao-fei, Hou, Bao-ke, Jin, Xin, Zhang, Mao-nian
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Boston Birkhäuser-Verlag 01.04.2012 Springer Nature B.V Springer US
Schlagworte:	Biomedical and Life Sciences Biomedicine Brain-derived neurotrophic factor Cell Biology Diabetes mellitus Diabetic neuropathy Neurobiology Neurosciences Original Research Overexpression Retina Retinal ganglion cells Viruses Adeno-associated virus (AAV) Streptzotocin(STZ) Diabetic retinopathy Gene therapy Brain-derived neurotrophic factor (BDNF)
ISSN:	0272-4340, 1573-6830, 1573-6830
Online-Zugang:	Volltext
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