Protective Effects of Adeno-associated Virus Mediated Brain-derived Neurotrophic Factor Expression on Retinal Ganglion Cells in Diabetic Rats

Adeno-associated virus vector plasmid carrying the expression cassette of brain-derived neurotrophic factor (BDNF), pAAV-BDNF, was constructed and packaged into recombinant adeno-associated virus (rAAV-BDNF). The rAAV-BDNF was intravitreally injected into streptzotocin (STZ)-induced diabetic Sprague...

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Veröffentlicht in:Cellular and molecular neurobiology Jg. 32; H. 3; S. 467 - 475
Hauptverfasser: Gong, Yan, Chang, Zhan-Ping, Ren, Ruo-Tong, Wei, Shi-hui, Zhou, Huan-Fen, Chen, Xiao-fei, Hou, Bao-ke, Jin, Xin, Zhang, Mao-nian
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Boston Birkhäuser-Verlag 01.04.2012
Springer Nature B.V
Springer US
Schlagworte:
Biomedical and Life Sciences
Biomedicine
Brain-derived neurotrophic factor
Cell Biology
Diabetes mellitus
Diabetic neuropathy
Neurobiology
Neurosciences
Original Research
Overexpression
Retina
Retinal ganglion cells
Viruses
Adeno-associated virus (AAV)
Streptzotocin(STZ)
Diabetic retinopathy
Gene therapy
Brain-derived neurotrophic factor (BDNF)
ISSN:0272-4340, 1573-6830, 1573-6830
Online-Zugang:Volltext
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Zusammenfassung:Adeno-associated virus vector plasmid carrying the expression cassette of brain-derived neurotrophic factor (BDNF), pAAV-BDNF, was constructed and packaged into recombinant adeno-associated virus (rAAV-BDNF). The rAAV-BDNF was intravitreally injected into streptzotocin (STZ)-induced diabetic Sprague–Dawley (SD) Rats. Data showed that over-expression of BDNF could increase alive retinal ganglion cell (RGC) number and improve its function in streptzotocin(STZ)-induced diabetic rats, which might be a new method to treat diabetic neuropathy andretinopathy.
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ISSN:0272-4340
1573-6830
1573-6830
DOI:10.1007/s10571-011-9779-x