Recombinant activated factor VII in clinical practice: a 2014 update

Recombinant activated factor VII (rFVIIa) was initially developed to treat bleeding episodes in patients with congenital hemophilia and inhibitors. Due to the initial success in this clinical setting, its use has been extended to other coagulopathies characterized by impaired thrombin generation, i....

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Vydané v:	Journal of thrombosis and thrombolysis Ročník 39; číslo 2; s. 235 - 240
Hlavní autori:	Franchini, Massimo, Crestani, Silvia, Frattini, Francesco, Sissa, Cinzia, Bonfanti, Carlo
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Boston Springer US 01.02.2015 Springer Nature B.V
Predmet:	Blood Coagulation - drug effects Cardiology Clinical Trials as Topic Factor VII Deficiency - drug therapy Factor VIIa - pharmacology Hematology Hemophilia A - drug therapy Hemostatics - pharmacology Humans Medicine Medicine & Public Health Recombinant Proteins - pharmacology Thrombasthenia - drug therapy FVII deficiency Recombinant activated FVII rFVIIa NovoSeven Hemophilia Acquired FVIII inhibitors Glanzmann’s thrombasthenia
ISSN:	0929-5305, 1573-742X, 1573-742X
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Abstract	Recombinant activated factor VII (rFVIIa) was initially developed to treat bleeding episodes in patients with congenital hemophilia and inhibitors. Due to the initial success in this clinical setting, its use has been extended to other coagulopathies characterized by impaired thrombin generation, i.e. acquired hemophilia, inherited factor VII deficiency and Glanzmann’s thrombasthenia, for which it is currently licensed. Extensive research in the last decade has increased our knowledge of the mechanisms utilized by rFVIIa to restore normal hemostasis. This paper reviews current understanding of the mechanisms of action of rFVIIa before summarizing the clinical experience, in terms of safety and efficacy, to date in its licensed indications.
AbstractList	Recombinant activated factor VII (rFVIIa) was initially developed to treat bleeding episodes in patients with congenital hemophilia and inhibitors. Due to the initial success in this clinical setting, its use has been extended to other coagulopathies characterized by impaired thrombin generation, i.e. acquired hemophilia, inherited factor VII deficiency and Glanzmann's thrombasthenia, for which it is currently licensed. Extensive research in the last decade has increased our knowledge of the mechanisms utilized by rFVIIa to restore normal hemostasis. This paper reviews current understanding of the mechanisms of action of rFVIIa before summarizing the clinical experience, in terms of safety and efficacy, to date in its licensed indications.Recombinant activated factor VII (rFVIIa) was initially developed to treat bleeding episodes in patients with congenital hemophilia and inhibitors. Due to the initial success in this clinical setting, its use has been extended to other coagulopathies characterized by impaired thrombin generation, i.e. acquired hemophilia, inherited factor VII deficiency and Glanzmann's thrombasthenia, for which it is currently licensed. Extensive research in the last decade has increased our knowledge of the mechanisms utilized by rFVIIa to restore normal hemostasis. This paper reviews current understanding of the mechanisms of action of rFVIIa before summarizing the clinical experience, in terms of safety and efficacy, to date in its licensed indications. Recombinant activated factor VII (rFVIIa) was initially developed to treat bleeding episodes in patients with congenital hemophilia and inhibitors. Due to the initial success in this clinical setting, its use has been extended to other coagulopathies characterized by impaired thrombin generation, i.e. acquired hemophilia, inherited factor VII deficiency and Glanzmann's thrombasthenia, for which it is currently licensed. Extensive research in the last decade has increased our knowledge of the mechanisms utilized by rFVIIa to restore normal hemostasis. This paper reviews current understanding of the mechanisms of action of rFVIIa before summarizing the clinical experience, in terms of safety and efficacy, to date in its licensed indications.
Author	Franchini, Massimo Sissa, Cinzia Bonfanti, Carlo Crestani, Silvia Frattini, Francesco
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Cites_doi	10.1053/j.seminhematol.2008.03.006 10.1016/S0140-6736(88)90259-0 10.1111/j.1365-2516.2006.01180.x 10.1055/s-0029-1245113 10.1055/s-0030-1255442 10.1111/j.1365-2125.2010.03899.x 10.1111/j.1365-2516.2009.02017.x 10.1016/j.blre.2013.06.002 10.1111/j.1538-7836.2012.04793.x 10.1053/j.seminhematol.2005.11.009 10.1055/s-0032-1309286 10.1016/S0268-960X(03)90000-2 10.3324/haematol.2012.074039 10.1111/j.1538-7836.2007.02576.x 10.1055/s-0032-1315757 10.1111/j.1538-7836.2009.03450.x 10.1160/TH12-07-0476 10.1111/j.1538-7836.2004.00759.x 10.1097/01.CCM.0000159087.85970.38 10.1046/j.1365-2141.1999.01128.x 10.1111/hae.12164 10.1161/01.ATV.0000031340.68494.34 10.1046/j.1538-7836.2003.00242.x 10.1111/j.1538-7836.2006.01772.x 10.1055/s-0033-1354425 10.1016/j.cca.2009.10.016 10.1046/j.1365-2516.2003.00782.x 10.1046/j.1423-0410.1999.7730131.x 10.1055/s-0029-1225762 10.1177/1076029608326165 10.1111/j.1365-2516.2008.01952.x 10.3324/haematol.2008.001743 10.1111/j.1365-2516.2007.01601.x 10.1111/j.1538-7836.2004.00767.x 10.1111/j.1365-2141.2010.08287.x 10.1182/blood-2008-03-143586 10.1111/j.1365-2516.2007.01474.x 10.1111/j.1365-2516.2010.02352.x 10.1182/blood-2012-02-408930 10.1160/TH13-05-0363 10.1046/j.1365-2141.2003.04286.x 10.1111/j.1365-2516.2007.01617.x 10.1046/j.1365-2141.1997.4463256.x 10.1182/blood.V94.11.3951 10.1055/s-0037-1615388 10.1055/s-0037-1613884 10.1160/TH08-07-0434 10.1055/s-0038-1650411 10.1055/s-0037-1614920 10.1160/TH05-07-0510 10.1055/s-0038-1665434
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Keywords	FVII deficiency Recombinant activated FVII rFVIIa NovoSeven Hemophilia Acquired FVIII inhibitors Glanzmann’s thrombasthenia
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PublicationSubtitle	A Journal for Translation, Application and Therapeutics in Thrombosis and Vascular Science
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References	Hoffman (CR12) 2003; 17 Kavakli, Makris, Zulfikar, Erhardtsen, Abrams, Kenet (CR24) 2006; 95 Hedner (CR8) 2008; 100 Key, Aledort, Beardsley (CR19) 1998; 80 Monroe, Hoffman, Roberts (CR13) 2002; 22 Baudo, de Cataldo, Gaidano (CR34) 2004; 89 Young, Shafer, Rojas, Seremetis (CR26) 2008; 14 Hedner, Lee (CR9) 2011; 17 Frattini, Bonfanti, Piccoli (CR43) 2013; 19 Franchini, Lippi (CR11) 2010; 36 Franchini, Mannucci (CR31) 2013; 110 Mariani, Bernardi (CR37) 2009; 35 Kisiel (CR7) 2009; 7 Poon, Demers, Jobin, Wu (CR49) 1999; 94 Tagliaferri, Franchini (CR54) 2013; 11 Cromwell, Aledort (CR4) 2012; 38 Franchini (CR3) 2013; 11 Franchini, Lippi (CR29) 2008; 112 Monroe, Hoffman, Oliver, Roberts (CR16) 1997; 99 Hoffman, Colina, McDonald, Arepally, Pedersen, Monroe (CR15) 2007; 5 Obergfell, Auvinen, Mathew (CR18) 2008; 14 Hay, Negrier, Ludlam (CR33) 1997; 78 Giangrande, Wilde, Madan (CR28) 2009; 15 Lloyd Jones, Wight, Paisley, Knight (CR22) 2003; 9 Mariani, Dolce, Batorova (CR40) 2011; 152 Franchini, Mannucci (CR6) 2013; 27 Abshire (CR56) 2008; 45 Hoffman, Dargaud (CR14) 2012; 10 Baudo, Collins, Huth-Kühne (CR36) 2012; 120 Abshire, Kenet (CR55) 2004; 2 Coppola, Favaloro, Tufano, Di Minno, Cerbone, Franchini (CR30) 2012; 38 He, Blombäck, Jacobsson Ekman, Hedner (CR17) 2003; 1 Mariani, Konkle, Ingerslev (CR39) 2006; 12 Franchini, Coppola, Tagliaferri, Lippi (CR57) 2013; 39 Poon, D’Oiron, Von Depka (CR51) 2004; 2 Huth-Kühne, Baudo, Collins (CR32) 2009; 94 Franchini, Favaloro, Lippi (CR44) 2010; 411 Santagostino, Gringeri, Mannucci (CR21) 1999; 104 Mariani, Napolitano, Dolce (CR41) 2013; 109 Franchini, Lippi (CR1) 2009; 35 Chuansumrit, Sangkapreecha, Hathirat (CR48) 1999; 82 Tengborn, Petruson (CR46) 1996; 75 Franchini, Mannucci (CR2) 2011; 72 Levi, Peters, Büller (CR23) 2005; 33 d’Oiron, Ménart, Trzeciak (CR50) 2000; 83 Shapiro (CR27) 2008; 6 Hedner, Glazer, Pingel (CR10) 1988; 2 Poon, Zotz, Di Minno, Abrams, Knudsen, Laurian (CR47) 2006; 43 Mariani, Testa, Di Paolantonio, Molskov Bech, Hedner (CR38) 1999; 77 Napolitano, Giansily-Blaizot, Dolce (CR42) 2013; 98 Lusher (CR5) 1991; 28 Santagostino, Mancuso, Rocino, Mancuso, Scaraggi, Mannucci (CR25) 2006; 4 Almeida, Khair, Hann, Liesner (CR52) 2003; 121 Giordano, Lassandro, Tesse (CR53) 2013; 11 Holme, Glomstein, Grønhaug, Tjønnfjord (CR20) 2009; 15 Sumner, Geldziler, Pedersen, Seremetis (CR35) 2007; 13 Kannan, Saxena (CR45) 2009; 15 NS Key (1114_CR19) 1998; 80 G Mariani (1114_CR41) 2013; 109 DM Monroe (1114_CR13) 2002; 22 G Mariani (1114_CR39) 2006; 12 M Franchini (1114_CR29) 2008; 112 F Frattini (1114_CR43) 2013; 19 P Giordano (1114_CR53) 2013; 11 R d’Oiron (1114_CR50) 2000; 83 M Franchini (1114_CR44) 2010; 411 T Abshire (1114_CR55) 2004; 2 PLF Giangrande (1114_CR28) 2009; 15 U Hedner (1114_CR10) 1988; 2 AM Almeida (1114_CR52) 2003; 121 S He (1114_CR17) 2003; 1 A Coppola (1114_CR30) 2012; 38 M Franchini (1114_CR57) 2013; 39 M Franchini (1114_CR31) 2013; 110 PA Holme (1114_CR20) 2009; 15 C Cromwell (1114_CR4) 2012; 38 MC Poon (1114_CR49) 1999; 94 G Mariani (1114_CR37) 2009; 35 M Hoffman (1114_CR15) 2007; 5 K Kavakli (1114_CR24) 2006; 95 U Hedner (1114_CR9) 2011; 17 A Obergfell (1114_CR18) 2008; 14 A Chuansumrit (1114_CR48) 1999; 82 CR Hay (1114_CR33) 1997; 78 M Franchini (1114_CR3) 2013; 11 MC Poon (1114_CR47) 2006; 43 M Kannan (1114_CR45) 2009; 15 MJ Sumner (1114_CR35) 2007; 13 AD Shapiro (1114_CR27) 2008; 6 M Franchini (1114_CR2) 2011; 72 G Young (1114_CR26) 2008; 14 MC Poon (1114_CR51) 2004; 2 M Hoffman (1114_CR12) 2003; 17 M Levi (1114_CR23) 2005; 33 M Franchini (1114_CR1) 2009; 35 M Franchini (1114_CR11) 2010; 36 DM Monroe (1114_CR16) 1997; 99 M Lloyd Jones (1114_CR22) 2003; 9 E Santagostino (1114_CR25) 2006; 4 A Tagliaferri (1114_CR54) 2013; 11 L Tengborn (1114_CR46) 1996; 75 M Hoffman (1114_CR14) 2012; 10 W Kisiel (1114_CR7) 2009; 7 M Napolitano (1114_CR42) 2013; 98 U Hedner (1114_CR8) 2008; 100 A Huth-Kühne (1114_CR32) 2009; 94 JM Lusher (1114_CR5) 1991; 28 E Santagostino (1114_CR21) 1999; 104 F Baudo (1114_CR36) 2012; 120 M Franchini (1114_CR6) 2013; 27 F Baudo (1114_CR34) 2004; 89 T Abshire (1114_CR56) 2008; 45 G Mariani (1114_CR38) 1999; 77 G Mariani (1114_CR40) 2011; 152 21158750 - Br J Haematol. 2011 Feb;152(3):340-6 17425666 - J Thromb Haemost. 2007 Jul;5(7):1403-8 15818119 - Crit Care Med. 2005 Apr;33(4):883-90 9869160 - Thromb Haemost. 1998 Dec;80(6):912-8 18081827 - Haemophilia. 2008 Mar;14 (2):233-41 15219192 - J Thromb Haemost. 2004 Jul;2(7):1096-103 15140125 - J Thromb Haemost. 2004 Jun;2(6):899-909 12716372 - Br J Haematol. 2003 May;121(3):477-81 10572113 - Blood. 1999 Dec 1;94(11):3951-3 21204915 - Br J Clin Pharmacol. 2011 Oct;72(4):553-62 1780767 - Semin Hematol. 1991 Jul;28(3 Suppl 6):3-5 20169517 - Semin Thromb Hemost. 2009 Nov;35(8):806-13 19598068 - Semin Thromb Hemost. 2009 Jun;35(4):400-6 19854165 - Clin Chim Acta. 2010 Jan;411(1-2):1-6 22460908 - Semin Thromb Hemost. 2012 Apr;38(3):265-7 22618709 - Blood. 2012 Jul 5;120(1):39-46 23238632 - Thromb Haemost. 2013 Feb;109(2):238-47 20609014 - Haemophilia. 2011 Jan;17 (1):e172-82 2903400 - Lancet. 1988 Nov 19;2(8621):1193 10823254 - Thromb Haemost. 2000 May;83(5):644-7 9401063 - Br J Haematol. 1997 Dec;99(3):542-7 16409171 - Haemophilia. 2006 Jan;12 (1):19-27 24008306 - Thromb Haemost. 2013 Dec;110(6):1114-20 12871322 - J Thromb Haemost. 2003 Jun;1(6):1215-9 22790269 - Blood Transfus. 2013 Jan;11(1):143-7 19320748 - Haemophilia. 2009 May;15(3):727-32 9423795 - Thromb Haemost. 1997 Dec;78(6):1463-7 18820600 - Clin Adv Hematol Oncol. 2008 Aug;6(8):579-86 22632160 - J Thromb Haemost. 2012 Aug;10 (8):1478-85 22790270 - Blood Transfus. 2013 Jan;11(1):12-3 8822604 - Thromb Haemost. 1996 Jun;75(6):981-2 15194550 - Haematologica. 2004 Jun;89(6):759-61 14697207 - Blood Rev. 2003 Sep;17 Suppl 1:S1-5 19336751 - Haematologica. 2009 Apr;94(4):566-75 12828680 - Haemophilia. 2003 Jul;9(4):464-520 17880429 - Haemophilia. 2007 Sep;13(5):451-61 18463353 - Blood. 2008 Jul 15;112(2):250-5 12231555 - Arterioscler Thromb Vasc Biol. 2002 Sep 1;22(9):1381-9 19187194 - Haemophilia. 2009 Mar;15(2):501-8 16420567 - J Thromb Haemost. 2006 Feb;4(2):367-71 18930954 - Clin Appl Thromb Hemost. 2009 Mar-Apr;15(2):152-65 10027707 - Br J Haematol. 1999 Jan;104(1):22-6 10545848 - Vox Sang. 1999;77(3):131-6 24014071 - Semin Thromb Hemost. 2013 Oct;39(7):772-8 23647837 - Haemophilia. 2013 Jul;19(4):e268-9 20632246 - Semin Thromb Hemost. 2010 Jul;36(5):485-92 22790275 - Blood Transfus. 2013 Apr;11(2):178-82 18544421 - Semin Hematol. 2008 Apr;45(2 Suppl 1):S3-6 23403322 - Haematologica. 2013 Apr;98(4):538-44 18841276 - Thromb Haemost. 2008 Oct;100(4):557-62 19422444 - J Thromb Haemost. 2009 Jul;7(7):1053-6 16427383 - Semin Hematol. 2006 Jan;43(1 Suppl 1):S33-6 16601828 - Thromb Haemost. 2006 Apr;95(4):600-5 22740182 - Semin Thromb Hemost. 2012 Jul;38(5):433-46 18081834 - Haemophilia. 2008 Mar;14 (2):287-94 10613676 - Thromb Haemost. 1999 Dec;82(6):1778 23815950 - Blood Rev. 2013 Jul;27(4):179-84
References_xml	– volume: 75 start-page: 981 year: 1996 end-page: 982 ident: CR46 article-title: A patient with Glanzmann thrombasthenia and epistaxis successfully treated with recombinant factor VIIa publication-title: Thromb Haemost – volume: 11 start-page: 178 year: 2013 end-page: 182 ident: CR3 article-title: The modern treatment of hemophilia: a narrative review publication-title: Blood Transfus – volume: 45 start-page: S3 issue: Suppl 1 year: 2008 end-page: S6 ident: CR56 article-title: Safety update on recombinant factor VIIa in the treatment of congenital and acquired hemophilia publication-title: Semin Hematol doi: 10.1053/j.seminhematol.2008.03.006 – volume: 2 start-page: 1193 year: 1988 ident: CR10 article-title: Successful use of rFVIIa in a patient with hemophilia A subjected to synovectomy publication-title: Lancet doi: 10.1016/S0140-6736(88)90259-0 – volume: 12 start-page: 19 year: 2006 end-page: 27 ident: CR39 article-title: Congenital factor VII deficiency: therapy with recombinant activated factor VII—a critical appraisal publication-title: Haemophilia doi: 10.1111/j.1365-2516.2006.01180.x – volume: 35 start-page: 806 year: 2009 end-page: 813 ident: CR1 article-title: Recent improvements in the clinical treatment of coagulation factor inhibitors publication-title: Semin Thromb Hemost doi: 10.1055/s-0029-1245113 – volume: 36 start-page: 485 year: 2010 end-page: 492 ident: CR11 article-title: Recombinant activated factor VII: mechanisms of action and current indications publication-title: Semin Thromb Hemost doi: 10.1055/s-0030-1255442 – volume: 72 start-page: 553 year: 2011 end-page: 562 ident: CR2 article-title: Inhibitors of propagation of coagulation (factors VIII, IX and XI): a review of current therapeutic practice publication-title: Br J Pharmacol doi: 10.1111/j.1365-2125.2010.03899.x – volume: 15 start-page: 727 year: 2009 end-page: 732 ident: CR20 article-title: Home treatment with bypassing products in inhibitor patients: a 7.5-year experience publication-title: Haemophilia doi: 10.1111/j.1365-2516.2009.02017.x – volume: 27 start-page: 179 year: 2013 end-page: 184 ident: CR6 article-title: Hemophilia A in the third millennium publication-title: Blood Rev doi: 10.1016/j.blre.2013.06.002 – volume: 10 start-page: 1478 year: 2012 end-page: 1485 ident: CR14 article-title: Mechanisms and monitoring of bypassing agent therapy publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2012.04793.x – volume: 95 start-page: 600 year: 2006 end-page: 605 ident: CR24 article-title: Home treatment of haemarthroses using a single dose regimen of recombinant activated factor VII in patients with haemophilia and inhibitors. A multi-centre, randomised, double-blind, cross-over trial publication-title: Thromb Haemost – volume: 43 start-page: S33 issue: 1 Suppl 1 year: 2006 end-page: S36 ident: CR47 article-title: Glanzmann’s thrombasthenia treatment: a prospective observational registry on the use of recombinant human activated factor VII and other hemostatic agents publication-title: Semin Hematol doi: 10.1053/j.seminhematol.2005.11.009 – volume: 38 start-page: 265 year: 2012 end-page: 267 ident: CR4 article-title: FEIBA: a prohemostatic agent publication-title: Semin Thromb Hemost doi: 10.1055/s-0032-1309286 – volume: 94 start-page: 3951 year: 1999 end-page: 3953 ident: CR49 article-title: Recombinant factor VIIa is effective for bleeding and surgery in patients with Glanzmann thrombasthenia publication-title: Blood – volume: 89 start-page: 759 year: 2004 end-page: 761 ident: CR34 article-title: Treatment of acquired factor VIII inhibitor with recombinant activated factor VIIa: data from the Italian registry of acquired hemophilia publication-title: Haematologica – volume: 17 start-page: S1 year: 2003 end-page: S5 ident: CR12 article-title: A cell-based model of coagulation and the role of factor VIIa publication-title: Blood Rev doi: 10.1016/S0268-960X(03)90000-2 – volume: 98 start-page: 538 year: 2013 end-page: 544 ident: CR42 article-title: Prophylaxis in congenital factor VII deficiency: indications, efficacy and safety. Results from the Seven Treatment Evaluation Registry (STER) publication-title: Haematologica doi: 10.3324/haematol.2012.074039 – volume: 5 start-page: 1403 year: 2007 end-page: 1408 ident: CR15 article-title: Tissue factor around dermal vessels has bound factor VII in the absence of injury publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2007.02576.x – volume: 38 start-page: 433 year: 2012 end-page: 446 ident: CR30 article-title: Acquired inhibitors of coagulation factors: part I-acquired hemophilia A publication-title: Semin Thromb Hemost doi: 10.1055/s-0032-1315757 – volume: 7 start-page: 1053 year: 2009 end-page: 1056 ident: CR7 article-title: Recollections on the discovery of factor VIIa as a novel therapeutic agent for hemophiliacs with inhibitors publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2009.03450.x – volume: 6 start-page: 579 year: 2008 end-page: 586 ident: CR27 article-title: Single-dose recombinant activated factor VII for the treatment of joint bleeds in hemophilia patients with inhibitors publication-title: Clin Adv Hematol Oncol – volume: 28 start-page: 3 issue: 3 Suppl 6 year: 1991 end-page: 5 ident: CR5 article-title: Thrombogenicity associated with factor IX complex concentrates publication-title: Semin Hematol – volume: 109 start-page: 238 year: 2013 end-page: 247 ident: CR41 article-title: Replacement therapy for bleeding episodes in factor VII deficiency. A prospective evaluation publication-title: Thromb Haemost doi: 10.1160/TH12-07-0476 – volume: 2 start-page: 899 year: 2004 end-page: 909 ident: CR55 article-title: Recombinant factor VIIa: review of efficacy, dosing regimens and safety in patients with congenital and acquired factor VIII or IX inhibitors publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2004.00759.x – volume: 33 start-page: 883 year: 2005 end-page: 890 ident: CR23 article-title: Efficacy and safety of recombinant factor VIIa for treatment of severe bleeding: a systematic review publication-title: Crit Care Med doi: 10.1097/01.CCM.0000159087.85970.38 – volume: 104 start-page: 22 year: 1999 end-page: 26 ident: CR21 article-title: Home treatment with recombinant activated factor VII in patients with factor VIII inhibitors: the advantages of early intervention publication-title: Br J Haematol doi: 10.1046/j.1365-2141.1999.01128.x – volume: 19 start-page: e268 year: 2013 end-page: e269 ident: CR43 article-title: Triple coronary artery bypass graft surgery in a patient with factor VII deficiency: a case report publication-title: Haemophilia doi: 10.1111/hae.12164 – volume: 22 start-page: 1381 year: 2002 end-page: 1389 ident: CR13 article-title: Platelets and thrombin generation publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000031340.68494.34 – volume: 1 start-page: 1215 year: 2003 end-page: 1219 ident: CR17 article-title: The role of recombinant factor VIIa (FVIIa) in fibrin structure in the absence of FVIII/FIX publication-title: J Thromb Haemost doi: 10.1046/j.1538-7836.2003.00242.x – volume: 4 start-page: 367 year: 2006 end-page: 371 ident: CR25 article-title: A prospective randomized trial of high and standard dosages of recombinant factor VIIa for treatment of hemarthroses in hemophiliacs with inhibitors publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2006.01772.x – volume: 39 start-page: 772 year: 2013 end-page: 778 ident: CR57 article-title: FEIBA versus NovoSeven in hemophilia patients with inhibitors publication-title: Semin Thromb Hemost doi: 10.1055/s-0033-1354425 – volume: 411 start-page: 1 year: 2010 end-page: 6 ident: CR44 article-title: Glanzmann thrombasthenia: an update publication-title: Clin Chim Acta doi: 10.1016/j.cca.2009.10.016 – volume: 100 start-page: 557 year: 2008 end-page: 562 ident: CR8 article-title: Factor VIIa and its potential therapeutic use in bleeding-associated pathologies publication-title: Thromb Haemost – volume: 9 start-page: 464 year: 2003 end-page: 520 ident: CR22 article-title: Control of bleeding in patients with haemophilia A with inhibitors: a systematic review publication-title: Haemophilia doi: 10.1046/j.1365-2516.2003.00782.x – volume: 77 start-page: 131 year: 1999 end-page: 136 ident: CR38 article-title: Use of recombinant, activated factor VII in the treatment of congenital factor VII deficiencies publication-title: Vox Sang doi: 10.1046/j.1423-0410.1999.7730131.x – volume: 80 start-page: 912 year: 1998 end-page: 918 ident: CR19 article-title: Home treatment of mild to moderate bleeding episodes using recombinant factor VIIa (Novoseven) in haemophiliacs with inhibitors publication-title: Thromb Haemost – volume: 35 start-page: 400 year: 2009 end-page: 406 ident: CR37 article-title: Factor VII deficiency publication-title: Semin Thromb Hemost doi: 10.1055/s-0029-1225762 – volume: 15 start-page: 152 year: 2009 end-page: 165 ident: CR45 article-title: Glanzmann’s thrombasthenia: an overview publication-title: Clin Appl Thromb Hemost doi: 10.1177/1076029608326165 – volume: 11 start-page: 143 year: 2013 end-page: 147 ident: CR53 article-title: Innovative use of recombinant activated factor VII during physical rehabilitation in an Italian child with Glanzmann’s thromboasthenia publication-title: Blood Transfus – volume: 15 start-page: 501 year: 2009 end-page: 508 ident: CR28 article-title: Consensus protocol for the use of recombinant activated factor VII (eptacog alfa (activated); NovoSeven) in elective orthopaedic surgery in haemophilic patients with inhibitors publication-title: Haemophilia doi: 10.1111/j.1365-2516.2008.01952.x – volume: 94 start-page: 566 year: 2009 end-page: 575 ident: CR32 article-title: International recommendations on the diagnosis and treatment of patients with acquired hemophilia A publication-title: Haematologica doi: 10.3324/haematol.2008.001743 – volume: 14 start-page: 287 year: 2008 end-page: 294 ident: CR26 article-title: Single 270 microg kg(-1)-dose rFVIIa vs. standard 90 microg kg(-1)-dose rFVIIa and APCC for home treatment of joint bleeds in haemophilia patients with inhibitors: a randomized comparison publication-title: Haemophilia doi: 10.1111/j.1365-2516.2007.01601.x – volume: 83 start-page: 644 year: 2000 end-page: 647 ident: CR50 article-title: Use of recombinant factor VIIa in 3 patients with inherited type I Glanzmann’s thrombasthenia undergoing invasive procedures publication-title: Thromb Haemost – volume: 2 start-page: 1096 year: 2004 end-page: 1103 ident: CR51 article-title: Prophylactic and therapeutic recombinant factor VIIa administration to patients with Glanzmann’s thrombasthenia: results of an international survey publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2004.00767.x – volume: 152 start-page: 340 year: 2011 end-page: 346 ident: CR40 article-title: Recombinant, activated factor VII for surgery in factor VII deficiency: a prospective evaluation—the surgical STER publication-title: Br J Haematol doi: 10.1111/j.1365-2141.2010.08287.x – volume: 112 start-page: 250 year: 2008 end-page: 255 ident: CR29 article-title: Acquired factor VIII inhibitors publication-title: Blood doi: 10.1182/blood-2008-03-143586 – volume: 13 start-page: 451 year: 2007 end-page: 461 ident: CR35 article-title: Treatment of acquired haemophilia with recombinant activated FVII: a critical appraisal publication-title: Haemophilia doi: 10.1111/j.1365-2516.2007.01474.x – volume: 17 start-page: e172 year: 2011 end-page: e182 ident: CR9 article-title: First 20 years with recombinant FVIIa (NovoSeven) publication-title: Haemophilia doi: 10.1111/j.1365-2516.2010.02352.x – volume: 120 start-page: 39 year: 2012 end-page: 46 ident: CR36 article-title: Management of bleeding in acquired hemophilia A: results from the European Acquired Haemophilia (EACH2) Registry publication-title: Blood doi: 10.1182/blood-2012-02-408930 – volume: 78 start-page: 1463 year: 1997 end-page: 1467 ident: CR33 article-title: The treatment of bleeding in acquired haemophilia with recombinant factor VIIa: a multicentre study publication-title: Thromb Haemost – volume: 110 start-page: 1114 year: 2013 end-page: 1120 ident: CR31 article-title: Acquired haemophilia: a 2013 update publication-title: Thromb Haemost doi: 10.1160/TH13-05-0363 – volume: 121 start-page: 477 year: 2003 end-page: 481 ident: CR52 article-title: The use of recombinant factor VIIa in children with inherited platelet function disorders publication-title: Br J Haematol doi: 10.1046/j.1365-2141.2003.04286.x – volume: 14 start-page: 233 year: 2008 end-page: 241 ident: CR18 article-title: Recombinant activated factor VII for haemophilia patients with inhibitors undergoing orthopaedic surgery: a review of the literature publication-title: Haemophilia doi: 10.1111/j.1365-2516.2007.01617.x – volume: 82 start-page: 1778 year: 1999 ident: CR48 article-title: Successful epistaxis control in a patient with Glanzmann thrombasthenia by increased bolus injection dose of recombinant factor VIIa publication-title: Thromb Haemost – volume: 99 start-page: 542 year: 1997 end-page: 547 ident: CR16 article-title: Platelet activity of high-dose factor VIIa is independent of tissue factor publication-title: Br J Haematol doi: 10.1046/j.1365-2141.1997.4463256.x – volume: 11 start-page: 12 year: 2013 end-page: 13 ident: CR54 article-title: The expanding role of prophylaxis with recombinant activated factor VII publication-title: Blood Transfus – volume: 112 start-page: 250 year: 2008 ident: 1114_CR29 publication-title: Blood doi: 10.1182/blood-2008-03-143586 – volume: 45 start-page: S3 issue: Suppl 1 year: 2008 ident: 1114_CR56 publication-title: Semin Hematol doi: 10.1053/j.seminhematol.2008.03.006 – volume: 6 start-page: 579 year: 2008 ident: 1114_CR27 publication-title: Clin Adv Hematol Oncol – volume: 13 start-page: 451 year: 2007 ident: 1114_CR35 publication-title: Haemophilia doi: 10.1111/j.1365-2516.2007.01474.x – volume: 15 start-page: 727 year: 2009 ident: 1114_CR20 publication-title: Haemophilia doi: 10.1111/j.1365-2516.2009.02017.x – volume: 15 start-page: 501 year: 2009 ident: 1114_CR28 publication-title: Haemophilia doi: 10.1111/j.1365-2516.2008.01952.x – volume: 5 start-page: 1403 year: 2007 ident: 1114_CR15 publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2007.02576.x – volume: 94 start-page: 566 year: 2009 ident: 1114_CR32 publication-title: Haematologica doi: 10.3324/haematol.2008.001743 – volume: 110 start-page: 1114 year: 2013 ident: 1114_CR31 publication-title: Thromb Haemost doi: 10.1160/TH13-05-0363 – volume: 39 start-page: 772 year: 2013 ident: 1114_CR57 publication-title: Semin Thromb Hemost doi: 10.1055/s-0033-1354425 – volume: 72 start-page: 553 year: 2011 ident: 1114_CR2 publication-title: Br J Pharmacol doi: 10.1111/j.1365-2125.2010.03899.x – volume: 94 start-page: 3951 year: 1999 ident: 1114_CR49 publication-title: Blood doi: 10.1182/blood.V94.11.3951 – volume: 1 start-page: 1215 year: 2003 ident: 1114_CR17 publication-title: J Thromb Haemost doi: 10.1046/j.1538-7836.2003.00242.x – volume: 35 start-page: 400 year: 2009 ident: 1114_CR37 publication-title: Semin Thromb Hemost doi: 10.1055/s-0029-1225762 – volume: 121 start-page: 477 year: 2003 ident: 1114_CR52 publication-title: Br J Haematol doi: 10.1046/j.1365-2141.2003.04286.x – volume: 109 start-page: 238 year: 2013 ident: 1114_CR41 publication-title: Thromb Haemost doi: 10.1160/TH12-07-0476 – volume: 80 start-page: 912 year: 1998 ident: 1114_CR19 publication-title: Thromb Haemost doi: 10.1055/s-0037-1615388 – volume: 11 start-page: 12 year: 2013 ident: 1114_CR54 publication-title: Blood Transfus – volume: 2 start-page: 1096 year: 2004 ident: 1114_CR51 publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2004.00767.x – volume: 83 start-page: 644 year: 2000 ident: 1114_CR50 publication-title: Thromb Haemost doi: 10.1055/s-0037-1613884 – volume: 411 start-page: 1 year: 2010 ident: 1114_CR44 publication-title: Clin Chim Acta doi: 10.1016/j.cca.2009.10.016 – volume: 120 start-page: 39 year: 2012 ident: 1114_CR36 publication-title: Blood doi: 10.1182/blood-2012-02-408930 – volume: 43 start-page: S33 issue: 1 Suppl 1 year: 2006 ident: 1114_CR47 publication-title: Semin Hematol doi: 10.1053/j.seminhematol.2005.11.009 – volume: 104 start-page: 22 year: 1999 ident: 1114_CR21 publication-title: Br J Haematol doi: 10.1046/j.1365-2141.1999.01128.x – volume: 14 start-page: 233 year: 2008 ident: 1114_CR18 publication-title: Haemophilia doi: 10.1111/j.1365-2516.2007.01617.x – volume: 99 start-page: 542 year: 1997 ident: 1114_CR16 publication-title: Br J Haematol doi: 10.1046/j.1365-2141.1997.4463256.x – volume: 100 start-page: 557 year: 2008 ident: 1114_CR8 publication-title: Thromb Haemost doi: 10.1160/TH08-07-0434 – volume: 98 start-page: 538 year: 2013 ident: 1114_CR42 publication-title: Haematologica doi: 10.3324/haematol.2012.074039 – volume: 11 start-page: 178 year: 2013 ident: 1114_CR3 publication-title: Blood Transfus – volume: 2 start-page: 899 year: 2004 ident: 1114_CR55 publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2004.00759.x – volume: 36 start-page: 485 year: 2010 ident: 1114_CR11 publication-title: Semin Thromb Hemost doi: 10.1055/s-0030-1255442 – volume: 75 start-page: 981 year: 1996 ident: 1114_CR46 publication-title: Thromb Haemost doi: 10.1055/s-0038-1650411 – volume: 35 start-page: 806 year: 2009 ident: 1114_CR1 publication-title: Semin Thromb Hemost doi: 10.1055/s-0029-1245113 – volume: 89 start-page: 759 year: 2004 ident: 1114_CR34 publication-title: Haematologica – volume: 17 start-page: S1 year: 2003 ident: 1114_CR12 publication-title: Blood Rev doi: 10.1016/S0268-960X(03)90000-2 – volume: 2 start-page: 1193 year: 1988 ident: 1114_CR10 publication-title: Lancet doi: 10.1016/S0140-6736(88)90259-0 – volume: 9 start-page: 464 year: 2003 ident: 1114_CR22 publication-title: Haemophilia doi: 10.1046/j.1365-2516.2003.00782.x – volume: 11 start-page: 143 year: 2013 ident: 1114_CR53 publication-title: Blood Transfus – volume: 17 start-page: e172 year: 2011 ident: 1114_CR9 publication-title: Haemophilia doi: 10.1111/j.1365-2516.2010.02352.x – volume: 15 start-page: 152 year: 2009 ident: 1114_CR45 publication-title: Clin Appl Thromb Hemost doi: 10.1177/1076029608326165 – volume: 77 start-page: 131 year: 1999 ident: 1114_CR38 publication-title: Vox Sang doi: 10.1046/j.1423-0410.1999.7730131.x – volume: 7 start-page: 1053 year: 2009 ident: 1114_CR7 publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2009.03450.x – volume: 27 start-page: 179 year: 2013 ident: 1114_CR6 publication-title: Blood Rev doi: 10.1016/j.blre.2013.06.002 – volume: 12 start-page: 19 year: 2006 ident: 1114_CR39 publication-title: Haemophilia doi: 10.1111/j.1365-2516.2006.01180.x – volume: 38 start-page: 433 year: 2012 ident: 1114_CR30 publication-title: Semin Thromb Hemost doi: 10.1055/s-0032-1315757 – volume: 14 start-page: 287 year: 2008 ident: 1114_CR26 publication-title: Haemophilia doi: 10.1111/j.1365-2516.2007.01601.x – volume: 82 start-page: 1778 year: 1999 ident: 1114_CR48 publication-title: Thromb Haemost doi: 10.1055/s-0037-1614920 – volume: 95 start-page: 600 year: 2006 ident: 1114_CR24 publication-title: Thromb Haemost doi: 10.1160/TH05-07-0510 – volume: 78 start-page: 1463 year: 1997 ident: 1114_CR33 publication-title: Thromb Haemost doi: 10.1055/s-0038-1665434 – volume: 19 start-page: e268 year: 2013 ident: 1114_CR43 publication-title: Haemophilia doi: 10.1111/hae.12164 – volume: 33 start-page: 883 year: 2005 ident: 1114_CR23 publication-title: Crit Care Med doi: 10.1097/01.CCM.0000159087.85970.38 – volume: 4 start-page: 367 year: 2006 ident: 1114_CR25 publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2006.01772.x – volume: 28 start-page: 3 issue: 3 Suppl 6 year: 1991 ident: 1114_CR5 publication-title: Semin Hematol – volume: 38 start-page: 265 year: 2012 ident: 1114_CR4 publication-title: Semin Thromb Hemost doi: 10.1055/s-0032-1309286 – volume: 10 start-page: 1478 year: 2012 ident: 1114_CR14 publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2012.04793.x – volume: 22 start-page: 1381 year: 2002 ident: 1114_CR13 publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000031340.68494.34 – volume: 152 start-page: 340 year: 2011 ident: 1114_CR40 publication-title: Br J Haematol doi: 10.1111/j.1365-2141.2010.08287.x – reference: 9869160 - Thromb Haemost. 1998 Dec;80(6):912-8 – reference: 18463353 - Blood. 2008 Jul 15;112(2):250-5 – reference: 10572113 - Blood. 1999 Dec 1;94(11):3951-3 – reference: 22618709 - Blood. 2012 Jul 5;120(1):39-46 – reference: 19854165 - Clin Chim Acta. 2010 Jan;411(1-2):1-6 – reference: 10823254 - Thromb Haemost. 2000 May;83(5):644-7 – reference: 19422444 - J Thromb Haemost. 2009 Jul;7(7):1053-6 – reference: 22740182 - Semin Thromb Hemost. 2012 Jul;38(5):433-46 – reference: 18841276 - Thromb Haemost. 2008 Oct;100(4):557-62 – reference: 15194550 - Haematologica. 2004 Jun;89(6):759-61 – reference: 19336751 - Haematologica. 2009 Apr;94(4):566-75 – reference: 16601828 - Thromb Haemost. 2006 Apr;95(4):600-5 – reference: 10613676 - Thromb Haemost. 1999 Dec;82(6):1778 – reference: 22790275 - Blood Transfus. 2013 Apr;11(2):178-82 – reference: 22460908 - Semin Thromb Hemost. 2012 Apr;38(3):265-7 – reference: 24008306 - Thromb Haemost. 2013 Dec;110(6):1114-20 – reference: 15219192 - J Thromb Haemost. 2004 Jul;2(7):1096-103 – reference: 24014071 - Semin Thromb Hemost. 2013 Oct;39(7):772-8 – reference: 18820600 - Clin Adv Hematol Oncol. 2008 Aug;6(8):579-86 – reference: 15818119 - Crit Care Med. 2005 Apr;33(4):883-90 – reference: 17425666 - J Thromb Haemost. 2007 Jul;5(7):1403-8 – reference: 14697207 - Blood Rev. 2003 Sep;17 Suppl 1:S1-5 – reference: 23403322 - Haematologica. 2013 Apr;98(4):538-44 – reference: 19598068 - Semin Thromb Hemost. 2009 Jun;35(4):400-6 – reference: 9423795 - Thromb Haemost. 1997 Dec;78(6):1463-7 – reference: 21204915 - Br J Clin Pharmacol. 2011 Oct;72(4):553-62 – reference: 20169517 - Semin Thromb Hemost. 2009 Nov;35(8):806-13 – reference: 22790269 - Blood Transfus. 2013 Jan;11(1):143-7 – reference: 2903400 - Lancet. 1988 Nov 19;2(8621):1193 – reference: 1780767 - Semin Hematol. 1991 Jul;28(3 Suppl 6):3-5 – reference: 18544421 - Semin Hematol. 2008 Apr;45(2 Suppl 1):S3-6 – reference: 8822604 - Thromb Haemost. 1996 Jun;75(6):981-2 – reference: 18081834 - Haemophilia. 2008 Mar;14 (2):287-94 – reference: 23238632 - Thromb Haemost. 2013 Feb;109(2):238-47 – reference: 19320748 - Haemophilia. 2009 May;15(3):727-32 – reference: 20609014 - Haemophilia. 2011 Jan;17 (1):e172-82 – reference: 12231555 - Arterioscler Thromb Vasc Biol. 2002 Sep 1;22(9):1381-9 – reference: 10027707 - Br J Haematol. 1999 Jan;104(1):22-6 – reference: 20632246 - Semin Thromb Hemost. 2010 Jul;36(5):485-92 – reference: 22790270 - Blood Transfus. 2013 Jan;11(1):12-3 – reference: 23647837 - Haemophilia. 2013 Jul;19(4):e268-9 – reference: 17880429 - Haemophilia. 2007 Sep;13(5):451-61 – reference: 16427383 - Semin Hematol. 2006 Jan;43(1 Suppl 1):S33-6 – reference: 22632160 - J Thromb Haemost. 2012 Aug;10 (8):1478-85 – reference: 12716372 - Br J Haematol. 2003 May;121(3):477-81 – reference: 16409171 - Haemophilia. 2006 Jan;12 (1):19-27 – reference: 18081827 - Haemophilia. 2008 Mar;14 (2):233-41 – reference: 16420567 - J Thromb Haemost. 2006 Feb;4(2):367-71 – reference: 12871322 - J Thromb Haemost. 2003 Jun;1(6):1215-9 – reference: 23815950 - Blood Rev. 2013 Jul;27(4):179-84 – reference: 19187194 - Haemophilia. 2009 Mar;15(2):501-8 – reference: 9401063 - Br J Haematol. 1997 Dec;99(3):542-7 – reference: 15140125 - J Thromb Haemost. 2004 Jun;2(6):899-909 – reference: 10545848 - Vox Sang. 1999;77(3):131-6 – reference: 18930954 - Clin Appl Thromb Hemost. 2009 Mar-Apr;15(2):152-65 – reference: 21158750 - Br J Haematol. 2011 Feb;152(3):340-6 – reference: 12828680 - Haemophilia. 2003 Jul;9(4):464-520
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Snippet	Recombinant activated factor VII (rFVIIa) was initially developed to treat bleeding episodes in patients with congenital hemophilia and inhibitors. Due to the...
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SubjectTerms	Blood Coagulation - drug effects Cardiology Clinical Trials as Topic Factor VII Deficiency - drug therapy Factor VIIa - pharmacology Hematology Hemophilia A - drug therapy Hemostatics - pharmacology Humans Medicine Medicine & Public Health Recombinant Proteins - pharmacology Thrombasthenia - drug therapy
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Title	Recombinant activated factor VII in clinical practice: a 2014 update
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