Recombinant activated factor VII in clinical practice: a 2014 update

Recombinant activated factor VII (rFVIIa) was initially developed to treat bleeding episodes in patients with congenital hemophilia and inhibitors. Due to the initial success in this clinical setting, its use has been extended to other coagulopathies characterized by impaired thrombin generation, i....

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Vydané v:Journal of thrombosis and thrombolysis Ročník 39; číslo 2; s. 235 - 240
Hlavní autori: Franchini, Massimo, Crestani, Silvia, Frattini, Francesco, Sissa, Cinzia, Bonfanti, Carlo
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Boston Springer US 01.02.2015
Springer Nature B.V
Predmet:
Blood Coagulation - drug effects
Cardiology
Clinical Trials as Topic
Factor VII Deficiency - drug therapy
Factor VIIa - pharmacology
Hematology
Hemophilia A - drug therapy
Hemostatics - pharmacology
Humans
Medicine
Medicine & Public Health
Recombinant Proteins - pharmacology
Thrombasthenia - drug therapy
FVII deficiency
Recombinant activated FVII
rFVIIa
NovoSeven
Hemophilia
Acquired FVIII inhibitors
Glanzmann’s thrombasthenia
ISSN:0929-5305, 1573-742X, 1573-742X
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Abstract Recombinant activated factor VII (rFVIIa) was initially developed to treat bleeding episodes in patients with congenital hemophilia and inhibitors. Due to the initial success in this clinical setting, its use has been extended to other coagulopathies characterized by impaired thrombin generation, i.e. acquired hemophilia, inherited factor VII deficiency and Glanzmann’s thrombasthenia, for which it is currently licensed. Extensive research in the last decade has increased our knowledge of the mechanisms utilized by rFVIIa to restore normal hemostasis. This paper reviews current understanding of the mechanisms of action of rFVIIa before summarizing the clinical experience, in terms of safety and efficacy, to date in its licensed indications.
AbstractList Recombinant activated factor VII (rFVIIa) was initially developed to treat bleeding episodes in patients with congenital hemophilia and inhibitors. Due to the initial success in this clinical setting, its use has been extended to other coagulopathies characterized by impaired thrombin generation, i.e. acquired hemophilia, inherited factor VII deficiency and Glanzmann’s thrombasthenia, for which it is currently licensed. Extensive research in the last decade has increased our knowledge of the mechanisms utilized by rFVIIa to restore normal hemostasis. This paper reviews current understanding of the mechanisms of action of rFVIIa before summarizing the clinical experience, in terms of safety and efficacy, to date in its licensed indications.
Recombinant activated factor VII (rFVIIa) was initially developed to treat bleeding episodes in patients with congenital hemophilia and inhibitors. Due to the initial success in this clinical setting, its use has been extended to other coagulopathies characterized by impaired thrombin generation, i.e. acquired hemophilia, inherited factor VII deficiency and Glanzmann's thrombasthenia, for which it is currently licensed. Extensive research in the last decade has increased our knowledge of the mechanisms utilized by rFVIIa to restore normal hemostasis. This paper reviews current understanding of the mechanisms of action of rFVIIa before summarizing the clinical experience, in terms of safety and efficacy, to date in its licensed indications.Recombinant activated factor VII (rFVIIa) was initially developed to treat bleeding episodes in patients with congenital hemophilia and inhibitors. Due to the initial success in this clinical setting, its use has been extended to other coagulopathies characterized by impaired thrombin generation, i.e. acquired hemophilia, inherited factor VII deficiency and Glanzmann's thrombasthenia, for which it is currently licensed. Extensive research in the last decade has increased our knowledge of the mechanisms utilized by rFVIIa to restore normal hemostasis. This paper reviews current understanding of the mechanisms of action of rFVIIa before summarizing the clinical experience, in terms of safety and efficacy, to date in its licensed indications.
Author Franchini, Massimo
Sissa, Cinzia
Bonfanti, Carlo
Crestani, Silvia
Frattini, Francesco
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Keywords FVII deficiency
Recombinant activated FVII
rFVIIa
NovoSeven
Hemophilia
Acquired FVIII inhibitors
Glanzmann’s thrombasthenia
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PublicationSubtitle A Journal for Translation, Application and Therapeutics in Thrombosis and Vascular Science
PublicationTitle Journal of thrombosis and thrombolysis
PublicationTitleAbbrev J Thromb Thrombolysis
PublicationTitleAlternate J Thromb Thrombolysis
PublicationYear 2015
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Snippet Recombinant activated factor VII (rFVIIa) was initially developed to treat bleeding episodes in patients with congenital hemophilia and inhibitors. Due to the...
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StartPage 235
SubjectTerms Blood Coagulation - drug effects
Cardiology
Clinical Trials as Topic
Factor VII Deficiency - drug therapy
Factor VIIa - pharmacology
Hematology
Hemophilia A - drug therapy
Hemostatics - pharmacology
Humans
Medicine
Medicine & Public Health
Recombinant Proteins - pharmacology
Thrombasthenia - drug therapy
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Title Recombinant activated factor VII in clinical practice: a 2014 update
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