Recombinant activated factor VII in clinical practice: a 2014 update

Recombinant activated factor VII (rFVIIa) was initially developed to treat bleeding episodes in patients with congenital hemophilia and inhibitors. Due to the initial success in this clinical setting, its use has been extended to other coagulopathies characterized by impaired thrombin generation, i....

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Vydáno v:Journal of thrombosis and thrombolysis Ročník 39; číslo 2; s. 235 - 240
Hlavní autoři: Franchini, Massimo, Crestani, Silvia, Frattini, Francesco, Sissa, Cinzia, Bonfanti, Carlo
Médium: Journal Article
Jazyk:angličtina
Vydáno: Boston Springer US 01.02.2015
Springer Nature B.V
Témata:
Blood Coagulation - drug effects
Cardiology
Clinical Trials as Topic
Factor VII Deficiency - drug therapy
Factor VIIa - pharmacology
Hematology
Hemophilia A - drug therapy
Hemostatics - pharmacology
Humans
Medicine
Medicine & Public Health
Recombinant Proteins - pharmacology
Thrombasthenia - drug therapy
FVII deficiency
Recombinant activated FVII
rFVIIa
NovoSeven
Hemophilia
Acquired FVIII inhibitors
Glanzmann’s thrombasthenia
ISSN:0929-5305, 1573-742X, 1573-742X
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Popis
Shrnutí:Recombinant activated factor VII (rFVIIa) was initially developed to treat bleeding episodes in patients with congenital hemophilia and inhibitors. Due to the initial success in this clinical setting, its use has been extended to other coagulopathies characterized by impaired thrombin generation, i.e. acquired hemophilia, inherited factor VII deficiency and Glanzmann’s thrombasthenia, for which it is currently licensed. Extensive research in the last decade has increased our knowledge of the mechanisms utilized by rFVIIa to restore normal hemostasis. This paper reviews current understanding of the mechanisms of action of rFVIIa before summarizing the clinical experience, in terms of safety and efficacy, to date in its licensed indications.
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ISSN:0929-5305
1573-742X
1573-742X
DOI:10.1007/s11239-014-1114-1