Helicobacter pylori secreted peptidyl prolyl cis, trans-isomerase drives Th17 inflammation in gastric adenocarcinoma

Helicobacter pylori infection is characterized by an inflammatory infiltrate, consisting mainly of neutrophils and T cells. This study was undertaken to evaluate the type of gastric T cell response elicited by the secreted peptidyl prolyl cis , trans -isomerase of H. pylori (HP0175) in patients with...

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Vydáno v:Internal and emergency medicine Ročník 9; číslo 3; s. 303 - 309
Hlavní autoři: Amedei, Amedeo, Munari, Fabio, Bella, Chiara Della, Niccolai, Elena, Benagiano, Marisa, Bencini, Lapo, Cianchi, Fabio, Farsi, Marco, Emmi, Giacomo, Zanotti, Giuseppe, de Bernard, Marina, Kundu, Manikuntala, D’Elios, Mario Milco
Médium: Journal Article
Jazyk:angličtina
Vydáno: Milan Springer Milan 01.04.2014
Springer Nature B.V
Témata:
Adenocarcinoma - immunology
Female
Helicobacter pylori
Helicobacter pylori - metabolism
Humans
Im - Original
Inflammation - immunology
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Peptidylprolyl Isomerase - biosynthesis
Peptidylprolyl Isomerase - physiology
Stomach Neoplasms - immunology
Th17 Cells - immunology
Tumor Cells, Cultured
Matrix metalloproteinase
Cytokines
Pathogenesis
Gastric cancer
Th17
VEGF
ISSN:1828-0447, 1970-9366, 1970-9366
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Shrnutí:Helicobacter pylori infection is characterized by an inflammatory infiltrate, consisting mainly of neutrophils and T cells. This study was undertaken to evaluate the type of gastric T cell response elicited by the secreted peptidyl prolyl cis , trans -isomerase of H. pylori (HP0175) in patients with distal gastric adenocarcinoma. The cytokine profile and the effector functions of gastric tumor-infiltrating lymphocytes (TILs) specific for HP0175 was investigated in 20 patients with distal gastric adenocarcinoma and H. pylori infection. The helper function of HP0175-specific TILs for monocyte MMP-2, MMP-9, and VEGF production was also investigated. TILs cells from H. pylori infected patients with distal gastric adenocarcinoma produced Interleukin (IL)-17 and IL-21 in response to HP0175. HP0175-specific TILs showed poor cytolytic activity while expressing helper activity for monocyte MMP-2, MMP-9 and VEGF production. These findings indicate that HP0175 is able to drive gastric Th17 response. Thus, HP0175, by promoting pro-inflammatory low cytotoxic TIL response, matrix degradation and pro-angiogenic pathways, may provide a link between H. pylori and gastric cancer.
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ISSN:1828-0447
1970-9366
1970-9366
DOI:10.1007/s11739-012-0867-9