Preprocessing Methods of Raman Spectra for Source Extraction on Biomedical Samples: Application on Paraffin-Embedded Skin Biopsies

Raman spectra are classically modeled as a linear mixing of spectra of molecular constituents of the analyzed sample. Source separation methods are thus well suited to estimate these constituent spectra. However, physical distortions due to the instrumentation and biological nature of samples add no...

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Bibliographic Details
Published in:	IEEE transactions on biomedical engineering Vol. 56; no. 5; pp. 1371 - 1382
Main Authors:	Gobinet, Cyril, Vrabie, Valeriu, Manfait, Michel, Piot, Olivier
Format:	Journal Article
Language:	English
Published:	United States IEEE 01.05.2009 The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects:	Algorithms Biological system modeling Biomedical optical imaging Biopsy Blind source separation Dark current Data Interpretation, Statistical digital dewaxing Humans Instruments Linear Models Models, Biological Optical detectors Optical distortion Optical mixing Paraffin Embedding paraffin-embedded skin biopsies preprocessing Principal Component Analysis Raman spectroscopy Signal Processing, Computer-Assisted Skin Skin - chemistry Source separation Specimen Handling Spectrum Analysis, Raman
ISSN:	0018-9294, 1558-2531, 1558-2531
Online Access:	Get full text
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