The Level of Anti-Viral Antigen-Specific Antibodies to EBNA-1 in the Serum of MS Patients Does not Depend on the Severity of the Disease

Multiple sclerosis (MS) is an autoimmune neurodegenerative disease leading to inevitable disability and primarily affecting the young and middle-aged population. Recent studies have shown a direct correlation between the risk of MS development and Epstein–Barr virus (EBV) infection. Analysis of the...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics Vol. 515; no. 1; pp. 48 - 51
Main Authors: Ovchinnikova, L. A., Dzhelad, S. S., Simaniv, T. O., Zakharova, M. N., Gabibov, A. G., Lomakin, Y. A.
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 01.04.2024
Springer Nature B.V
Subjects:
Amyotrophic lateral sclerosis
Antibodies
Antibodies, Viral
Antigens
Antiviral Agents
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Disease
EBNA-1 protein
Epstein-Barr virus
Epstein-Barr Virus Infections - epidemiology
Epstein-Barr Virus Nuclear Antigens
Herpesvirus 4, Human
Humans
Immunoglobulin G
Life Sciences
Middle Aged
Multiple Sclerosis
Neurodegenerative Diseases
Peptides
Population studies
Proteins
Viral infections
EBNA-1
EBV
autoantibodies
MS
multiple sclerosis
Epstein–Barr virus
ISSN:1607-6729, 1608-3091, 1608-3091
Online Access:Get full text
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Summary:Multiple sclerosis (MS) is an autoimmune neurodegenerative disease leading to inevitable disability and primarily affecting the young and middle-aged population. Recent studies have shown a direct correlation between the risk of MS development and Epstein–Barr virus (EBV) infection. Analysis of the titer of EBV-specific antibodies among patients with MS and healthy donors among Russian population confirmed that MS is characterized by an increased level of serum IgG binding EBNA-1 (EBV nuclear antigen 1). The number of patients with elevated levels of EBNA-1-specific antibodies does not differ statistically significantly between two groups with diametrically opposite courses of MS: benign MS or highly active MS. It can be assumed that the primary link between EBV and the development of MS is restricted to the initiation of the disease and does not impact its severity.
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ISSN:1607-6729
1608-3091
1608-3091
DOI:10.1134/S1607672924700753