Development of a multi-parametric model predictive control algorithm for insulin delivery in type 1 diabetes mellitus using clinical parameters
A multi-parametric model predictive control (mpMPC) algorithm for subcutaneous insulin delivery for individuals with type 1 diabetes mellitus (T1DM) that is computationally efficient, robust to variations in insulin sensitivity, and involves minimal burden for the user is proposed. System identifica...
Saved in:
| Published in: | Journal of process control Vol. 21; no. 3; pp. 391 - 404 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Elsevier Ltd
01.03.2011
|
| Subjects: | |
| ISSN: | 0959-1524, 1873-2771 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | A multi-parametric model predictive control (mpMPC) algorithm for subcutaneous insulin delivery for individuals with type 1 diabetes mellitus (T1DM) that is computationally efficient, robust to variations in insulin sensitivity, and involves minimal burden for the user is proposed. System identification was achieved through impulse response tests feasible for ambulatory conditions on the UVa/Padova simulator adult subjects with T1DM. An alternative means of system identification using readily available clinical parameters was also investigated. A safety constraint was included explicitly in the algorithm formulation using clinical parameters typical of those available to an attending physician. Closed-loop simulations were carried out with daily consumption of 200
g carbohydrate. Controller robustness was assessed by subject/model mismatch scenarios addressing daily, simultaneous variation in insulin sensitivity and meal size with the addition of Gaussian white noise with a standard deviation of 10%. A second-order-plus-time-delay transfer function model fit the validation data with a mean (coefficient of variation) root-mean-square-error (RMSE) of 26
mg/dL (19%) for a 3
h prediction horizon. The resulting control law maintained a low risk Low Blood Glucose Index without any information about carbohydrate consumption for 90% of the subjects. Low-order linear models with clinically meaningful parameters thus provided sufficient information for a model predictive control algorithm to control glycemia. The use of clinical knowledge as a safety constraint can reduce hypoglycemic events, and this same knowledge can further improve glycemic control when used explicitly as the controller model. The resulting mpMPC algorithm was sufficiently compact to be implemented on a simple electronic device. |
|---|---|
| AbstractList | A multi-parametric model predictive control (mpMPC) algorithm for subcutaneous insulin delivery for individuals with type 1 diabetes mellitus (T1DM) that is computationally efficient, robust to variations in insulin sensitivity, and involves minimal burden for the user is proposed. System identification was achieved through impulse response tests feasible for ambulatory conditions on the UVa/Padova simulator adult subjects with T1DM. An alternative means of system identification using readily available clinical parameters was also investigated. A safety constraint was included explicitly in the algorithm formulation using clinical parameters typical of those available to an attending physician. Closed-loop simulations were carried out with daily consumption of 200 g carbohydrate. Controller robustness was assessed by subject/model mismatch scenarios addressing daily, simultaneous variation in insulin sensitivity and meal size with the addition of Gaussian white noise with a standard deviation of 10%. A second-order-plus-time-delay transfer function model fit the validation data with a mean (coefficient of variation) root-mean-square-error (RMSE) of 26 mg/dL (19%) for a 3 h prediction horizon. The resulting control law maintained a low risk Low Blood Glucose Index without any information about carbohydrate consumption for 90% of the subjects. Low-order linear models with clinically meaningful parameters thus provided sufficient information for a model predictive control algorithm to control glycemia. The use of clinical knowledge as a safety constraint can reduce hypoglycemic events, and this same knowledge can further improve glycemic control when used explicitly as the controller model. The resulting mpMPC algorithm was sufficiently compact to be implemented on a simple electronic device.A multi-parametric model predictive control (mpMPC) algorithm for subcutaneous insulin delivery for individuals with type 1 diabetes mellitus (T1DM) that is computationally efficient, robust to variations in insulin sensitivity, and involves minimal burden for the user is proposed. System identification was achieved through impulse response tests feasible for ambulatory conditions on the UVa/Padova simulator adult subjects with T1DM. An alternative means of system identification using readily available clinical parameters was also investigated. A safety constraint was included explicitly in the algorithm formulation using clinical parameters typical of those available to an attending physician. Closed-loop simulations were carried out with daily consumption of 200 g carbohydrate. Controller robustness was assessed by subject/model mismatch scenarios addressing daily, simultaneous variation in insulin sensitivity and meal size with the addition of Gaussian white noise with a standard deviation of 10%. A second-order-plus-time-delay transfer function model fit the validation data with a mean (coefficient of variation) root-mean-square-error (RMSE) of 26 mg/dL (19%) for a 3 h prediction horizon. The resulting control law maintained a low risk Low Blood Glucose Index without any information about carbohydrate consumption for 90% of the subjects. Low-order linear models with clinically meaningful parameters thus provided sufficient information for a model predictive control algorithm to control glycemia. The use of clinical knowledge as a safety constraint can reduce hypoglycemic events, and this same knowledge can further improve glycemic control when used explicitly as the controller model. The resulting mpMPC algorithm was sufficiently compact to be implemented on a simple electronic device. A multi-parametric model predictive control (mpMPC) algorithm for subcutaneous insulin delivery for individuals with type 1 diabetes mellitus (T1DM) that is computationally efficient, robust to variations in insulin sensitivity, and involves minimal burden for the user is proposed. System identification was achieved through impulse response tests feasible for ambulatory conditions on the UVa/Padova simulator adult subjects with T1DM. An alternative means of system identification using readily available clinical parameters was also investigated. A safety constraint was included explicitly in the algorithm formulation using clinical parameters typical of those available to an attending physician. Closed-loop simulations were carried out with daily consumption of 200 g carbohydrate. Controller robustness was assessed by subject/model mismatch scenarios addressing daily, simultaneous variation in insulin sensitivity and meal size with the addition of Gaussian white noise with a standard deviation of 10%. A second-order-plus-time-delay transfer function model fit the validation data with a mean (coefficient of variation) root-mean-square-error (RMSE) of 26 mg/dL (19%) for a 3 h prediction horizon. The resulting control law maintained a low risk Low Blood Glucose Index without any information about carbohydrate consumption for 90% of the subjects. Low-order linear models with clinically meaningful parameters thus provided sufficient information for a model predictive control algorithm to control glycemia. The use of clinical knowledge as a safety constraint can reduce hypoglycemic events, and this same knowledge can further improve glycemic control when used explicitly as the controller model. The resulting mpMPC algorithm was sufficiently compact to be implemented on a simple electronic device. A multi-parametric model predictive control (mpMPC) algorithm for subcutaneous insulin delivery for individuals with type 1 diabetes mellitus (T1DM) that is computationally efficient, robust to variations in insulin sensitivity, and involves minimal burden for the user is proposed. System identification was achieved through impulse response tests feasible for ambulatory conditions on the UVa/Padova simulator adult subjects with T1DM. An alternative means of system identification using readily available clinical parameters was also investigated. A safety constraint was included explicitly in the algorithm formulation using clinical parameters typical of those available to an attending physician. Closed-loop simulations were carried out with daily consumption of 200 g carbohydrate. Controller robustness was assessed by subject/model mismatch scenarios addressing daily, simultaneous variation in insulin sensitivity and meal size with the addition of Gaussian white noise with a standard deviation of 10%. A second-order-plus-time-delay transfer function model fit the validation data with a mean (coefficient of variation) root-mean-square-error (RMSE) of 26 mg/dL (19%) for a 3 h prediction horizon. The resulting control law maintained a low risk Low Blood Glucose Index without any information about carbohydrate consumption for 90% of the subjects. Low-order linear models with clinically meaningful parameters thus provided sufficient information for a model predictive control algorithm to control glycemia. The use of clinical knowledge as a safety constraint can reduce hypoglycemic events, and this same knowledge can further improve glycemic control when used explicitly as the controller model. The resulting mpMPC algorithm was sufficiently compact to be implemented on a simple electronic device. |
| Author | Dassau, E. Jovanovič, L. Doyle, F.J. Wang, Y. Percival, M.W. Zisser, H. Grosman, B. |
| AuthorAffiliation | a Department of Chemical Engineering, University of California, Santa Barbara, CA 93106-5080, United States b Sansum Diabetes Research Institute, Santa Barbara, CA 93105-4321, United States |
| AuthorAffiliation_xml | – name: a Department of Chemical Engineering, University of California, Santa Barbara, CA 93106-5080, United States – name: b Sansum Diabetes Research Institute, Santa Barbara, CA 93105-4321, United States |
| Author_xml | – sequence: 1 givenname: M.W. surname: Percival fullname: Percival, M.W. email: percival@engineering.ucsb.edu organization: Department of Chemical Engineering, University of California, Santa Barbara, CA 93106-5080, United States – sequence: 2 givenname: Y. surname: Wang fullname: Wang, Y. email: kewangyq@engineering.ucsb.edu organization: Department of Chemical Engineering, University of California, Santa Barbara, CA 93106-5080, United States – sequence: 3 givenname: B. surname: Grosman fullname: Grosman, B. email: grosmanb@engineering.ucsb.edu organization: Department of Chemical Engineering, University of California, Santa Barbara, CA 93106-5080, United States – sequence: 4 givenname: E. surname: Dassau fullname: Dassau, E. email: dassau@engineering.ucsb.edu organization: Department of Chemical Engineering, University of California, Santa Barbara, CA 93106-5080, United States – sequence: 5 givenname: H. surname: Zisser fullname: Zisser, H. email: hzisser@sansum.org organization: Department of Chemical Engineering, University of California, Santa Barbara, CA 93106-5080, United States – sequence: 6 givenname: L. surname: Jovanovič fullname: Jovanovič, L. email: ljovanovic@sansum.org organization: Department of Chemical Engineering, University of California, Santa Barbara, CA 93106-5080, United States – sequence: 7 givenname: F.J. surname: Doyle fullname: Doyle, F.J. email: doyle@engineering.ucsb.edu organization: Department of Chemical Engineering, University of California, Santa Barbara, CA 93106-5080, United States |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21516218$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkc2KFDEUhYOMOD2jrzBk6abaJJX6AxFl_IUBN7oOqeRWz21SlTJJNfRT-Mqm7GlRN7MK3HznHO49V-Ri8hMQcsPZljNev9pv93Pwxk9pK9jv4Zax8gnZ8LYpC9E0_IJsWFd1Ba-EvCRXMe5ZJhpRPyOXgle8FrzdkJ_v4QDOzyNMifqBajouLmEx66BHSAENHb0FR-cAFk3CA9A1NXhHtdv5gOl-pIMPFKe4OJxohjMUjnlA03EGyqlF3UOCSEdwDtMS6RJx2lGTeTQ6m5_SIMTn5OmgXYQXD-81-f7xw7fbz8Xd109fbt_dFUY2PBWdZgy6Wpvetkxy2VpTy7qpOitYJ8xgbCmgLzvZs04LkKypBls2Zdkz3g4Cymvy5uQ7L_0I1uT1g3ZqDjjqcFReo_r3Z8J7tfMHVbKmE0xmg5cPBsH_WCAmNWI0eT89gV-i4q2oed1I2WX05u-sPyHnFjLw-gSY4GMMMCiDSSdc76zRKc7UWrraq3Ppai19nedKs7z-T35OeFT49iSEfOkDQlDRIEwmNx3AJGU9PmbxC6PXz9g |
| CitedBy_id | crossref_primary_10_1007_s13346_020_00876_4 crossref_primary_10_1016_j_ifacol_2025_06_012 crossref_primary_10_1371_journal_pone_0217301 crossref_primary_10_1016_j_asoc_2015_06_041 crossref_primary_10_1016_j_conengprac_2014_02_012 crossref_primary_10_15446_dyna_v85n207_71535 crossref_primary_10_1016_j_conengprac_2018_05_006 crossref_primary_10_1177_1932296817704444 crossref_primary_10_1016_j_compbiomed_2025_109714 crossref_primary_10_3390_pr4040035 crossref_primary_10_1177_0142331217701538 crossref_primary_10_1016_j_bspc_2014_10_003 crossref_primary_10_1177_193229681300700624 crossref_primary_10_3390_math9111200 crossref_primary_10_1016_j_cmpb_2011_11_006 crossref_primary_10_1177_1932296819880864 crossref_primary_10_1007_s00500_014_1378_6 crossref_primary_10_1016_j_jtice_2014_06_005 crossref_primary_10_1016_j_jprocont_2019_03_007 crossref_primary_10_1007_s11517_018_1832_1 crossref_primary_10_2337_dc12_0948 crossref_primary_10_1088_1757_899X_428_1_012035 crossref_primary_10_1002_rnc_1746 crossref_primary_10_1016_j_eswa_2014_10_038 crossref_primary_10_1002_cnm_2833 crossref_primary_10_1016_j_cmpb_2012_03_001 crossref_primary_10_1002_oca_1006 crossref_primary_10_1016_j_cmpb_2012_03_002 crossref_primary_10_1016_j_jprocont_2018_02_003 crossref_primary_10_1109_ACCESS_2023_3259425 crossref_primary_10_1109_TBME_2021_3125839 crossref_primary_10_1016_S1874_1029_13_60024_5 crossref_primary_10_1016_j_engappai_2019_103255 crossref_primary_10_1016_j_jprocont_2018_05_003 crossref_primary_10_3390_nu16142214 crossref_primary_10_1016_j_arcontrol_2012_09_007 crossref_primary_10_1109_ACCESS_2021_3076405 |
| Cites_doi | 10.1109/51.897829 10.2337/diabetes.44.8.968 10.1177/193229680700100603 10.1016/j.compchemeng.2005.05.014 10.1007/s00125-008-1205-7 10.2337/diabetes.37.7.901 10.1089/dia.2008.0065 10.1177/193229680800200429 10.1016/j.diabres.2004.11.005 10.1016/j.jprocont.2007.07.008 10.1056/NEJM199309303291401 10.1109/10.740877 10.2337/dc09-1487 10.1177/193229681000400522 10.1016/S0140-6736(09)61998-X 10.1109/TBME.2007.893506 10.1177/193229680900300319 10.1177/193229680800200412 10.2337/dc09-1080 10.1109/TBME.2009.2024409 10.1002/aic.11699 10.1109/TBME.2006.883792 10.1088/0967-3334/25/4/010 10.1177/193229680900300106 10.1089/152091502320798312 10.1089/dia.2005.7.72 10.1111/j.1464-5491.2005.01672.x 10.1016/0140-6736(92)90594-S 10.1177/193229680900300512 10.1007/978-3-540-24743-2_30 10.1152/ajpendo.00304.2001 10.1016/S0025-7125(16)30707-6 10.1109/TBME.2006.878075 10.1021/ie801432u 10.1089/dia.2008.0032 10.1016/j.diabres.2004.07.009 10.7326/0003-4819-145-5-200609050-00005 10.1016/S0005-1098(01)00174-1 10.2337/diacare.21.11.1870 10.1089/dia.2005.7.28 10.1001/archinte.167.11.1145 10.1109/TBME.1983.325203 10.1016/j.jprocont.2007.07.010 10.1016/S0169-2607(96)01784-1 10.1016/j.compchemeng.2004.06.010 10.1021/ie901891c 10.1089/dia.2007.0202 10.1089/dia.2005.7.48 10.1089/152091502760098438 10.1109/TBME.2004.839639 |
| ContentType | Journal Article |
| Copyright | 2010 Elsevier Ltd 2010 Elsevier Ltd. All rights reserved. 2010 |
| Copyright_xml | – notice: 2010 Elsevier Ltd – notice: 2010 Elsevier Ltd. All rights reserved. 2010 |
| DBID | AAYXX CITATION NPM 7X8 5PM |
| DOI | 10.1016/j.jprocont.2010.10.003 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Engineering Computer Science |
| EISSN | 1873-2771 |
| EndPage | 404 |
| ExternalDocumentID | PMC3079204 21516218 10_1016_j_jprocont_2010_10_003 S0959152410001897 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: NIDDK NIH HHS grantid: R01 DK085628 |
| GroupedDBID | --K --M .DC .~1 0R~ 1B1 1~. 1~5 29L 4.4 457 4G. 5GY 5VS 7-5 71M 8P~ 9JN AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABFNM ABFRF ABJNI ABMAC ABNUV ABTAH ABXDB ABYKQ ACDAQ ACGFO ACGFS ACNNM ACRLP ADBBV ADEWK ADEZE ADMUD ADTZH AEBSH AECPX AEFWE AEKER AENEX AFKWA AFTJW AGHFR AGUBO AGYEJ AHHHB AHJVU AHPOS AIEXJ AIKHN AITUG AJBFU AJOXV AKURH ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BBWZM BJAXD BKOJK BLXMC CS3 DU5 EBS EFJIC EFLBG EJD ENUVR EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLY HVGLF HZ~ IHE J1W JJJVA KOM LX7 LY7 M41 MO0 N9A NDZJH O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCE SDF SDG SDP SES SET SEW SPC SPCBC SSG SST SSZ T5K UNMZH WUQ XFK ZMT ZY4 ~G- 9DU AATTM AAXKI AAYWO AAYXX ABWVN ACLOT ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS ~HD AFXIZ AGCQF AGRNS NPM SSH 7X8 5PM |
| ID | FETCH-LOGICAL-c471t-9a00e96acbd804148dc646759d2092cfcd32eb394b09a2e4075fd3733b018f2e3 |
| ISICitedReferencesCount | 52 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000289389000009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0959-1524 |
| IngestDate | Tue Sep 30 16:29:01 EDT 2025 Sun Nov 09 13:36:42 EST 2025 Mon Jul 21 06:04:07 EDT 2025 Sat Nov 29 05:09:46 EST 2025 Tue Nov 18 21:48:09 EST 2025 Fri Feb 23 02:16:54 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | T1DM FDA CF Multi-parametric model predictive control BG Biomedical control CGM CHO IV CSII SC IIT ICR Insulin delivery Type 1 diabetes mellitus |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c471t-9a00e96acbd804148dc646759d2092cfcd32eb394b09a2e4075fd3733b018f2e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Now at Beijing University of Chemical Technology, China. |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/3079204 |
| PMID | 21516218 |
| PQID | 1826167449 |
| PQPubID | 23479 |
| PageCount | 14 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3079204 proquest_miscellaneous_1826167449 pubmed_primary_21516218 crossref_citationtrail_10_1016_j_jprocont_2010_10_003 crossref_primary_10_1016_j_jprocont_2010_10_003 elsevier_sciencedirect_doi_10_1016_j_jprocont_2010_10_003 |
| PublicationCentury | 2000 |
| PublicationDate | 2011-03-01 |
| PublicationDateYYYYMMDD | 2011-03-01 |
| PublicationDate_xml | – month: 03 year: 2011 text: 2011-03-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Journal of process control |
| PublicationTitleAlternate | J Process Control |
| PublicationYear | 2011 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Heinemann (bib21) 2002; 4 Magni, Raimondo, Bossi, Dalla Man, de Nicolao, Kovatchev, Cobelli (bib14) 2007; 1 Hopkins (bib19) 2004; 65 Finan, Zisser, Jovanovič, Bevier, Seborg (bib26) 2007; 9 Percival, Dassau, Zisser, Jovanovič, Doyle (bib37) 2009; 48 Hovorka, Allen, Elleri, Chassin, Harris, Xing, Kollman, Hovorka, Larsen, Nodale, Palma, Wilinska, Acerini, Dunger (bib15) 2010; 375 Allen, Kerr, Smythe, Martin, Osola, Thompson (bib18) 1992; 339 Wansink, Chandon (bib55) 2006; 145 Wilinska, Chassin, Schaller, Schaupp, Pieber, Hovorka (bib24) 2005; 52 Kvasnica, Grieder, Baotic, Morari (bib44) 2004; 2993 L. Jovanovič, Insulin therapy and algorithms for treating type 1 diabetes mellitus, in: Optimizing insulin therapy in patients with diabetes, CME Activity jointly sponsored by Washington Hospital Center and MedStar Research Institute, 2002, pp. 13–19. Bequette (bib6) 2005; 7 Buckingham, Cobry, Clinton, Gage, Caswell, Kunselman, Cameron, Chase (bib48) 2009; 11 Renard, Place, Cantwell, Chevassus, Palerm (bib8) 2010; 33 Palerm, Zisser, Doyle (bib51) 2008; 18 Wang, Dassau, Doyle (bib52) 2010; 57 Dalla Man, Camilleri, Cobelli (bib22) 2006; 53 Diabetes Control and Complications Trials Research Group (bib2) 1993; 329 Hovorka, Canonico, Chassin, Haueter, Massi-Benedetti, Federici, Pieber, Schaller, Schaupp, Vering, Wilinska (bib13) 2004; 25 Percival, Bevier, Wang, Dassau, Zisser, Jovanovič, Doyle (bib28) 2010; 4 Diabetes Control and Complications Trials Research Group (bib3) 1995; 44 Vicini, Sparacino, Caumo, Cobelli (bib35) 1997; 52 Bemporad, Morari, Dua, Pistikopoulos (bib30) 2002; 38 Löfberg (bib45) 2004; 1 Kovatchev, Cox, Gonder-Frederick, Young-Hyman, Schlundt, Clarke (bib39) 1998; 21 Cameron, Niemeyer, Gundy-Burlet, Buckingham (bib47) 2008; 2 Finan, Palerm, Doyle, Seborg, Zisser, Bevier, Jovanovič (bib27) 2009; 55 Hovorka (bib9) 2006; 23 Franco, Steyerberg, Hu, Mackenbach, Nusselder (bib1) 2007; 167 Kovatchev, Cox, Gonder-Frederick, Clarke (bib56) 2002; 4 Parker, Doyle, Peppas (bib12) 1999; 46 Scheiner, Boyer (bib20) 2005; 69 Dalla Man, Rizza, Cobelli (bib36) 2007; 54 Grancharova, Johansen, Kocijan (bib43) 2004; 28 Amiel, Sherwin, Simonson, Tamborlane (bib4) 1988; 37 Kovatchev, Breton, Man, Cobelli (bib33) 2009; 3 Tatò, Tatò, Beyer, Schrezenmeir (bib17) 1991; 17 Seborg, Edgar, Mellichamp (bib41) 2004 Hovorka, Shojaee-Moradie, Carroll, Chassin, Gowrie, Jackson, Tudor, Umpleby, Jones (bib23) 2002; 282 Chassin, Wilinska, Hovorka (bib57) 2005; 7 Ellingsen, Dassau, Zisser, Grosman, Percival, Jovanovič, Doyle (bib11) 2009; 3 Cobelli, Ruggeri (bib34) 1983; 30 Parker, Doyle, Peppas (bib10) 2001; 20 Dua, Pistikopoulos (bib31) 2005; 29 Renard (bib7) 2008; 2 Nelson, Cox (bib16) 2005 Cryer (bib5) 2009; 52 Bantle (bib46) 1988; 72 Finan, Zisser, Jovanovič, Bevier, Seborg (bib50) 2010; 49 Walsh, Roberts (bib42) 2006 Zisser, Jovanovič, Doyle, Ospina, Owens (bib29) 2005; 7 Dua, Doyle, Pistikopoulos (bib32) 2006; 53 Dassau, Cameron, Lee, Bequette, Zisser, Jovanovič, Chase, Wilson, Buckingham, Doyle (bib49) 2010; 33 Magni, Forgione, Toffanin, Man, Kovatchev, Nicolao, Cobelli (bib53) 2009; 3 Percival, Grosman, Dassau, Zisser, Jovanovič, Doyle (bib38) 2009 Oruklu, Cinar, Quinn, Smith (bib25) 2009; 11 Marchetti, Barolo, Jovanovič, Zisser, Seborg (bib40) 2008; 18 Löfberg (10.1016/j.jprocont.2010.10.003_bib45) 2004; 1 Zisser (10.1016/j.jprocont.2010.10.003_bib29) 2005; 7 Hopkins (10.1016/j.jprocont.2010.10.003_bib19) 2004; 65 Hovorka (10.1016/j.jprocont.2010.10.003_bib15) 2010; 375 Percival (10.1016/j.jprocont.2010.10.003_bib28) 2010; 4 Hovorka (10.1016/j.jprocont.2010.10.003_bib23) 2002; 282 Cryer (10.1016/j.jprocont.2010.10.003_bib5) 2009; 52 Wang (10.1016/j.jprocont.2010.10.003_bib52) 2010; 57 Finan (10.1016/j.jprocont.2010.10.003_bib26) 2007; 9 Bequette (10.1016/j.jprocont.2010.10.003_bib6) 2005; 7 Cameron (10.1016/j.jprocont.2010.10.003_bib47) 2008; 2 Kovatchev (10.1016/j.jprocont.2010.10.003_bib39) 1998; 21 Dalla Man (10.1016/j.jprocont.2010.10.003_bib36) 2007; 54 Wilinska (10.1016/j.jprocont.2010.10.003_bib24) 2005; 52 Chassin (10.1016/j.jprocont.2010.10.003_bib57) 2005; 7 Marchetti (10.1016/j.jprocont.2010.10.003_bib40) 2008; 18 Ellingsen (10.1016/j.jprocont.2010.10.003_bib11) 2009; 3 Tatò (10.1016/j.jprocont.2010.10.003_bib17) 1991; 17 Diabetes Control and Complications Trials Research Group (10.1016/j.jprocont.2010.10.003_bib2) 1993; 329 Cobelli (10.1016/j.jprocont.2010.10.003_bib34) 1983; 30 Palerm (10.1016/j.jprocont.2010.10.003_bib51) 2008; 18 Vicini (10.1016/j.jprocont.2010.10.003_bib35) 1997; 52 Kovatchev (10.1016/j.jprocont.2010.10.003_bib33) 2009; 3 Percival (10.1016/j.jprocont.2010.10.003_bib38) 2009 Bemporad (10.1016/j.jprocont.2010.10.003_bib30) 2002; 38 Walsh (10.1016/j.jprocont.2010.10.003_bib42) 2006 Wansink (10.1016/j.jprocont.2010.10.003_bib55) 2006; 145 Dua (10.1016/j.jprocont.2010.10.003_bib31) 2005; 29 Dua (10.1016/j.jprocont.2010.10.003_bib32) 2006; 53 Oruklu (10.1016/j.jprocont.2010.10.003_bib25) 2009; 11 Percival (10.1016/j.jprocont.2010.10.003_bib37) 2009; 48 Kovatchev (10.1016/j.jprocont.2010.10.003_bib56) 2002; 4 Hovorka (10.1016/j.jprocont.2010.10.003_bib9) 2006; 23 Renard (10.1016/j.jprocont.2010.10.003_bib8) 2010; 33 Dassau (10.1016/j.jprocont.2010.10.003_bib49) 2010; 33 Heinemann (10.1016/j.jprocont.2010.10.003_bib21) 2002; 4 Parker (10.1016/j.jprocont.2010.10.003_bib10) 2001; 20 Seborg (10.1016/j.jprocont.2010.10.003_bib41) 2004 Parker (10.1016/j.jprocont.2010.10.003_bib12) 1999; 46 Scheiner (10.1016/j.jprocont.2010.10.003_bib20) 2005; 69 Buckingham (10.1016/j.jprocont.2010.10.003_bib48) 2009; 11 Franco (10.1016/j.jprocont.2010.10.003_bib1) 2007; 167 Dalla Man (10.1016/j.jprocont.2010.10.003_bib22) 2006; 53 Diabetes Control and Complications Trials Research Group (10.1016/j.jprocont.2010.10.003_bib3) 1995; 44 Finan (10.1016/j.jprocont.2010.10.003_bib27) 2009; 55 Hovorka (10.1016/j.jprocont.2010.10.003_bib13) 2004; 25 Allen (10.1016/j.jprocont.2010.10.003_bib18) 1992; 339 10.1016/j.jprocont.2010.10.003_bib54 Nelson (10.1016/j.jprocont.2010.10.003_bib16) 2005 Grancharova (10.1016/j.jprocont.2010.10.003_bib43) 2004; 28 Amiel (10.1016/j.jprocont.2010.10.003_bib4) 1988; 37 Renard (10.1016/j.jprocont.2010.10.003_bib7) 2008; 2 Finan (10.1016/j.jprocont.2010.10.003_bib50) 2010; 49 Kvasnica (10.1016/j.jprocont.2010.10.003_bib44) 2004; 2993 Magni (10.1016/j.jprocont.2010.10.003_bib53) 2009; 3 Magni (10.1016/j.jprocont.2010.10.003_bib14) 2007; 1 Bantle (10.1016/j.jprocont.2010.10.003_bib46) 1988; 72 |
| References_xml | – volume: 48 start-page: 6059 year: 2009 end-page: 6067 ident: bib37 article-title: Practical approach to design and implementation of a control algorithm in an artificial pancreatic beta cell publication-title: Ind. Eng. Chem. Res. – volume: 3 start-page: 536 year: 2009 end-page: 544 ident: bib11 article-title: Safety constraints in an artificial pancreatic publication-title: J. Diabetes Sci. Technol. – volume: 1 start-page: 284 year: 2004 end-page: 289 ident: bib45 article-title: YALMIP: a toolbox for modeling and optimization in MATLAB publication-title: IEEE Int. Symp. Comp. Aided Contr. Syst. Des. – volume: 2 start-page: 612 year: 2008 end-page: 621 ident: bib47 article-title: Statistical hypoglycemia prediction publication-title: J. Diabetes Sci. Technol. – volume: 37 start-page: 901 year: 1988 end-page: 907 ident: bib4 article-title: Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release publication-title: Diabetes – volume: 52 start-page: 35 year: 2009 end-page: 37 ident: bib5 article-title: Preventing hypoglycaemia: what is the appropriate glucose alert value? publication-title: Diabetologia – volume: 20 start-page: 65 year: 2001 end-page: 73 ident: bib10 article-title: The intravenous route to blood glucose control publication-title: IEEE Eng. Med. Biol. – volume: 33 start-page: 121 year: 2010 end-page: 127 ident: bib8 article-title: Closed-loop insulin delivery using a subcutaneous glucose sensor and intraperitoneal insulin delivery: feasibility study testing a new model for the artificial pancreas publication-title: Diabetes Care – volume: 52 start-page: 147 year: 1997 end-page: 156 ident: bib35 article-title: Estimation of endogenous glucose production after a glucose perturbation by nonparametric stochastic deconvolution publication-title: Comput. Methods Programs Biomed. – volume: 55 start-page: 1135 year: 2009 end-page: 1146 ident: bib27 article-title: Effect of input excitation on the quality of empirical dynamic models for type 1 diabetes publication-title: AIChE J. – volume: 23 start-page: 1 year: 2006 end-page: 12 ident: bib9 article-title: Continuous glucose monitoring and closed-loop systems publication-title: Diabet. Med. – volume: 44 start-page: 968 year: 1995 end-page: 983 ident: bib3 article-title: The relationship of glycemic exposure HbA1c to the risk of development and progression of retinopathy in the diabetes control and complications trial publication-title: Diabetes – volume: 1 start-page: 804 year: 2007 end-page: 815 ident: bib14 article-title: Model predictive control of type 1 diabetes: an in silico trial publication-title: J. Diabetes Sci. Technol. – volume: 4 start-page: 295 year: 2002 end-page: 303 ident: bib56 article-title: Methods for quantifying self-monitoring blood glucose profiles exemplified by an examination of blood glucose patterns in patients with type 1 and type 2 diabetes publication-title: Diabetes Technol. Ther. – volume: 375 start-page: 743 year: 2010 end-page: 751 ident: bib15 article-title: Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial publication-title: Lancet – volume: 46 start-page: 148 year: 1999 end-page: 157 ident: bib12 article-title: A model-based algorithm for blood glucose control in type I diabetic patients publication-title: IEEE Trans. Biomed. Eng. – volume: 52 start-page: 3 year: 2005 end-page: 12 ident: bib24 article-title: Insulin kinetics in type-1 diabetes: continuous and bolus delivery of rapid acting insulin publication-title: IEEE Trans. Biomed. Eng. – volume: 7 start-page: 48 year: 2005 end-page: 57 ident: bib29 article-title: Run-to-run control of meal-related insulin dosing publication-title: Diabetes Technol. Ther. – volume: 11 start-page: 243 year: 2009 end-page: 253 ident: bib25 article-title: Estimation of future glucose concentrations with subject-specific recursive linear models publication-title: Diabetes Technol. Ther. – volume: 329 start-page: 977 year: 1993 end-page: 986 ident: bib2 article-title: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus publication-title: N. Engl. J. Med. – year: 2006 ident: bib42 article-title: Pumping Insulin – year: 2004 ident: bib41 article-title: Process Dynamics and Control – volume: 29 start-page: 2290 year: 2005 end-page: 2296 ident: bib31 article-title: Modelling and control of drug delivery systems publication-title: Comput. Chem. Eng. – volume: 49 start-page: 7843 year: 2010 end-page: 7848 ident: bib50 article-title: Automatic detection of stress states in type 1 diabetes subjects in ambulatory conditions publication-title: Ind. Eng. Chem. Res. – volume: 38 start-page: 3 year: 2002 end-page: 20 ident: bib30 article-title: The explicit linear quadratic regulator for constrained systems publication-title: Automatica – volume: 18 start-page: 149 year: 2008 end-page: 162 ident: bib40 article-title: A feedforward-feedback glucose control strategy for type 1 diabetes mellitus publication-title: J. Process Control – volume: 28 start-page: 2481 year: 2004 end-page: 2491 ident: bib43 article-title: Explicit model predictive control of gas-liquid separation plant via orthogonal search tree partitioning publication-title: Comput. Chem. Eng. – volume: 11 start-page: 93 year: 2009 end-page: 97 ident: bib48 article-title: Preventing hypoglycemia using predictive alarm algorithms and insulin pump suspension publication-title: Diabetes Technol. Ther. – volume: 72 start-page: 1285 year: 1988 end-page: 1299 ident: bib46 article-title: The dietary treatment of diabetes mellitus publication-title: Med. Clin. North Am. – volume: 7 start-page: 72 year: 2005 end-page: 82 ident: bib57 article-title: Grading system to assess clinical performance of closed-loop glucose control publication-title: Diabetes Technol. Ther. – volume: 69 start-page: 14 year: 2005 end-page: 21 ident: bib20 article-title: Characteristics of basal insulin requirements by age and gender in type-1 diabetes patients using insulin pump therapy publication-title: Diabetes Res. Clin. Pract. – volume: 65 start-page: S35 year: 2004 end-page: S39 ident: bib19 article-title: Exercise-induced and other daytime hypoglycemic events in patients with diabetes: prevention and treatment publication-title: Diabetes Res. Clin. Pract. – volume: 30 start-page: 93 year: 1983 end-page: 103 ident: bib34 article-title: Evaluation of portal/peripheral route and of algorithms for insulin delivery in the closed-loop control of glucose in diabetes—a modeling study publication-title: IEEE Trans. Biomed. Eng. – volume: 18 start-page: 258 year: 2008 end-page: 265 ident: bib51 article-title: A run-to-run control strategy to adjust basal insulin infusion rates in type 1 diabetes publication-title: J. Process Control – volume: 33 start-page: 1249 year: 2010 end-page: 1254 ident: bib49 article-title: Realtime hypoglycemia prediction suite using continuous glucose monitoring (CGM), a safety net for the artificial pancreas publication-title: Diabetes Care – volume: 53 start-page: 2472 year: 2006 end-page: 2478 ident: bib22 article-title: A system model of oral glucose absorption: validation on gold standard data publication-title: IEEE Trans. Biomed. Eng. – volume: 282 start-page: E992 year: 2002 end-page: E1007 ident: bib23 article-title: Partitioning glucose distribution/transport, disposal, and endogenous production during IVGTT publication-title: Am. J. Physiol. Endocrinol. Metab. – volume: 3 start-page: 1091 year: 2009 end-page: 1098 ident: bib53 article-title: Run-to-run tuning of model predictive control for type 1 diabetes subjects: in silico trial publication-title: J. Diabetes Sci. Technol. – volume: 53 start-page: 1478 year: 2006 end-page: 1491 ident: bib32 article-title: Model-based blood glucose control for type 1 diabetes via parametric programming publication-title: IEEE Trans. Biomed. Eng. – volume: 7 start-page: 28 year: 2005 end-page: 47 ident: bib6 article-title: A critical assessment of algorithms and challenges in the development of a closed-loop artificial pancreas publication-title: Diabetes Technol. Ther. – volume: 25 start-page: 905 year: 2004 end-page: 920 ident: bib13 article-title: Nonlinear model predictive control of glucose concentration in subjects with type 1 diabetes publication-title: Physiol. Meas. – volume: 57 start-page: 211 year: 2010 end-page: 219 ident: bib52 article-title: Closed-loop control of artificial pancreatic publication-title: IEEE Trans. Biomed. Eng. – volume: 17 start-page: 13 year: 1991 end-page: 24 ident: bib17 article-title: Circadian variation of basal and postprandial insulin sensitivity in healthy individuals and patients with type-1 diabetes publication-title: Diabetes Res. – volume: 9 start-page: 438 year: 2007 end-page: 450 ident: bib26 article-title: Practical issues in the identification of empirical models from simulated type 1 diabetes data publication-title: Diabetes Technol. Ther. – year: 2009 ident: bib38 publication-title: Am. Diabetes Assoc. 69th Scientific Sessions – volume: 145 start-page: 326 year: 2006 end-page: 332 ident: bib55 article-title: Meal size, not body size, explains errors in estimating the calorie content of meals publication-title: Ann. Intern. Med. – volume: 2993 start-page: 448 year: 2004 end-page: 462 ident: bib44 article-title: Multi-parametric toolbox (MPT) publication-title: Hybrid Syst.: Comput. Control – volume: 2 start-page: 735 year: 2008 end-page: 738 ident: bib7 article-title: Insulin delivery route for the artificial pancreas: subcutaneous, intraperitoneal, or intravenous? pros and cons publication-title: J. Diabetes Sci. Technol. – volume: 4 start-page: 1214 year: 2010 end-page: 1228 ident: bib28 article-title: Modeling the effects of subcutaneous insulin administration and carbohydrate consumption on blood glucose publication-title: J. Diabetes Sci. Technol. – volume: 21 start-page: 1870 year: 1998 end-page: 1875 ident: bib39 article-title: Assessment of risk for severe hypoglycemia among adults with IDDM: validation of the low blood glucose index publication-title: Diabetes Care – volume: 4 start-page: 673 year: 2002 end-page: 682 ident: bib21 article-title: Variability of insulin absorption and insulin action publication-title: Diabetes Technol. Ther. – volume: 3 start-page: 44 year: 2009 end-page: 55 ident: bib33 article-title: In silico preclinical trials: a proof of concept in closed-loop control of type 1 diabetes publication-title: J. Diabetes Sci. Technol. – volume: 54 start-page: 1740 year: 2007 end-page: 1749 ident: bib36 article-title: Meal simulation model of the glucose–insulin system publication-title: IEEE Trans. Biomed. Eng. – year: 2005 ident: bib16 article-title: Principles of Biochemistry – volume: 339 start-page: 1065 year: 1992 end-page: 1066 ident: bib18 article-title: Insulin sensitivity after phototherapy for seasonal affective disorder publication-title: Lancet – volume: 167 start-page: 1145 year: 2007 end-page: 1151 ident: bib1 article-title: Associations of diabetes mellitus with total life expectancy and life expectancy with and without cardiovascular disease publication-title: Arch. Intern. Med. – reference: L. Jovanovič, Insulin therapy and algorithms for treating type 1 diabetes mellitus, in: Optimizing insulin therapy in patients with diabetes, CME Activity jointly sponsored by Washington Hospital Center and MedStar Research Institute, 2002, pp. 13–19. – volume: 20 start-page: 65 issue: 1 year: 2001 ident: 10.1016/j.jprocont.2010.10.003_bib10 article-title: The intravenous route to blood glucose control publication-title: IEEE Eng. Med. Biol. doi: 10.1109/51.897829 – volume: 44 start-page: 968 issue: 8 year: 1995 ident: 10.1016/j.jprocont.2010.10.003_bib3 article-title: The relationship of glycemic exposure HbA1c to the risk of development and progression of retinopathy in the diabetes control and complications trial publication-title: Diabetes doi: 10.2337/diabetes.44.8.968 – volume: 1 start-page: 804 issue: 6 year: 2007 ident: 10.1016/j.jprocont.2010.10.003_bib14 article-title: Model predictive control of type 1 diabetes: an in silico trial publication-title: J. Diabetes Sci. Technol. doi: 10.1177/193229680700100603 – ident: 10.1016/j.jprocont.2010.10.003_bib54 – volume: 29 start-page: 2290 issue: 11–12 year: 2005 ident: 10.1016/j.jprocont.2010.10.003_bib31 article-title: Modelling and control of drug delivery systems publication-title: Comput. Chem. Eng. doi: 10.1016/j.compchemeng.2005.05.014 – volume: 52 start-page: 35 issue: 1 year: 2009 ident: 10.1016/j.jprocont.2010.10.003_bib5 article-title: Preventing hypoglycaemia: what is the appropriate glucose alert value? publication-title: Diabetologia doi: 10.1007/s00125-008-1205-7 – volume: 37 start-page: 901 issue: 7 year: 1988 ident: 10.1016/j.jprocont.2010.10.003_bib4 article-title: Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release publication-title: Diabetes doi: 10.2337/diabetes.37.7.901 – year: 2005 ident: 10.1016/j.jprocont.2010.10.003_bib16 – volume: 11 start-page: 243 issue: 4 year: 2009 ident: 10.1016/j.jprocont.2010.10.003_bib25 article-title: Estimation of future glucose concentrations with subject-specific recursive linear models publication-title: Diabetes Technol. Ther. doi: 10.1089/dia.2008.0065 – volume: 2 start-page: 735 issue: 4 year: 2008 ident: 10.1016/j.jprocont.2010.10.003_bib7 article-title: Insulin delivery route for the artificial pancreas: subcutaneous, intraperitoneal, or intravenous? pros and cons publication-title: J. Diabetes Sci. Technol. doi: 10.1177/193229680800200429 – volume: 69 start-page: 14 issue: 1 year: 2005 ident: 10.1016/j.jprocont.2010.10.003_bib20 article-title: Characteristics of basal insulin requirements by age and gender in type-1 diabetes patients using insulin pump therapy publication-title: Diabetes Res. Clin. Pract. doi: 10.1016/j.diabres.2004.11.005 – volume: 18 start-page: 149 issue: 2 year: 2008 ident: 10.1016/j.jprocont.2010.10.003_bib40 article-title: A feedforward-feedback glucose control strategy for type 1 diabetes mellitus publication-title: J. Process Control doi: 10.1016/j.jprocont.2007.07.008 – volume: 329 start-page: 977 year: 1993 ident: 10.1016/j.jprocont.2010.10.003_bib2 article-title: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199309303291401 – year: 2009 ident: 10.1016/j.jprocont.2010.10.003_bib38 publication-title: Am. Diabetes Assoc. 69th Scientific Sessions – volume: 46 start-page: 148 issue: 2 year: 1999 ident: 10.1016/j.jprocont.2010.10.003_bib12 article-title: A model-based algorithm for blood glucose control in type I diabetic patients publication-title: IEEE Trans. Biomed. Eng. doi: 10.1109/10.740877 – volume: 33 start-page: 1249 issue: 6 year: 2010 ident: 10.1016/j.jprocont.2010.10.003_bib49 article-title: Realtime hypoglycemia prediction suite using continuous glucose monitoring (CGM), a safety net for the artificial pancreas publication-title: Diabetes Care doi: 10.2337/dc09-1487 – volume: 4 start-page: 1214 issue: 5 year: 2010 ident: 10.1016/j.jprocont.2010.10.003_bib28 article-title: Modeling the effects of subcutaneous insulin administration and carbohydrate consumption on blood glucose publication-title: J. Diabetes Sci. Technol. doi: 10.1177/193229681000400522 – volume: 375 start-page: 743 issue: 9716 year: 2010 ident: 10.1016/j.jprocont.2010.10.003_bib15 article-title: Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial publication-title: Lancet doi: 10.1016/S0140-6736(09)61998-X – volume: 54 start-page: 1740 issue: 10 year: 2007 ident: 10.1016/j.jprocont.2010.10.003_bib36 article-title: Meal simulation model of the glucose–insulin system publication-title: IEEE Trans. Biomed. Eng. doi: 10.1109/TBME.2007.893506 – volume: 3 start-page: 536 issue: 3 year: 2009 ident: 10.1016/j.jprocont.2010.10.003_bib11 article-title: Safety constraints in an artificial pancreatic β cell: an implementation of model predictive control with insulin on board publication-title: J. Diabetes Sci. Technol. doi: 10.1177/193229680900300319 – year: 2006 ident: 10.1016/j.jprocont.2010.10.003_bib42 – volume: 2 start-page: 612 issue: 4 year: 2008 ident: 10.1016/j.jprocont.2010.10.003_bib47 article-title: Statistical hypoglycemia prediction publication-title: J. Diabetes Sci. Technol. doi: 10.1177/193229680800200412 – volume: 33 start-page: 121 issue: 1 year: 2010 ident: 10.1016/j.jprocont.2010.10.003_bib8 article-title: Closed-loop insulin delivery using a subcutaneous glucose sensor and intraperitoneal insulin delivery: feasibility study testing a new model for the artificial pancreas publication-title: Diabetes Care doi: 10.2337/dc09-1080 – volume: 57 start-page: 211 issue: 2 year: 2010 ident: 10.1016/j.jprocont.2010.10.003_bib52 article-title: Closed-loop control of artificial pancreatic β-cell in type 1 diabetes mellitus using model predictive iterative learning control publication-title: IEEE Trans. Biomed. Eng. doi: 10.1109/TBME.2009.2024409 – volume: 55 start-page: 1135 issue: 5 year: 2009 ident: 10.1016/j.jprocont.2010.10.003_bib27 article-title: Effect of input excitation on the quality of empirical dynamic models for type 1 diabetes publication-title: AIChE J. doi: 10.1002/aic.11699 – volume: 53 start-page: 2472 issue: 12 year: 2006 ident: 10.1016/j.jprocont.2010.10.003_bib22 article-title: A system model of oral glucose absorption: validation on gold standard data publication-title: IEEE Trans. Biomed. Eng. doi: 10.1109/TBME.2006.883792 – volume: 25 start-page: 905 issue: 4 year: 2004 ident: 10.1016/j.jprocont.2010.10.003_bib13 article-title: Nonlinear model predictive control of glucose concentration in subjects with type 1 diabetes publication-title: Physiol. Meas. doi: 10.1088/0967-3334/25/4/010 – volume: 3 start-page: 44 issue: 1 year: 2009 ident: 10.1016/j.jprocont.2010.10.003_bib33 article-title: In silico preclinical trials: a proof of concept in closed-loop control of type 1 diabetes publication-title: J. Diabetes Sci. Technol. doi: 10.1177/193229680900300106 – year: 2004 ident: 10.1016/j.jprocont.2010.10.003_bib41 – volume: 4 start-page: 673 issue: 5 year: 2002 ident: 10.1016/j.jprocont.2010.10.003_bib21 article-title: Variability of insulin absorption and insulin action publication-title: Diabetes Technol. Ther. doi: 10.1089/152091502320798312 – volume: 7 start-page: 72 issue: 1 year: 2005 ident: 10.1016/j.jprocont.2010.10.003_bib57 article-title: Grading system to assess clinical performance of closed-loop glucose control publication-title: Diabetes Technol. Ther. doi: 10.1089/dia.2005.7.72 – volume: 23 start-page: 1 issue: 1 year: 2006 ident: 10.1016/j.jprocont.2010.10.003_bib9 article-title: Continuous glucose monitoring and closed-loop systems publication-title: Diabet. Med. doi: 10.1111/j.1464-5491.2005.01672.x – volume: 339 start-page: 1065 issue: 8800 year: 1992 ident: 10.1016/j.jprocont.2010.10.003_bib18 article-title: Insulin sensitivity after phototherapy for seasonal affective disorder publication-title: Lancet doi: 10.1016/0140-6736(92)90594-S – volume: 3 start-page: 1091 issue: 5 year: 2009 ident: 10.1016/j.jprocont.2010.10.003_bib53 article-title: Run-to-run tuning of model predictive control for type 1 diabetes subjects: in silico trial publication-title: J. Diabetes Sci. Technol. doi: 10.1177/193229680900300512 – volume: 2993 start-page: 448 year: 2004 ident: 10.1016/j.jprocont.2010.10.003_bib44 article-title: Multi-parametric toolbox (MPT) publication-title: Hybrid Syst.: Comput. Control doi: 10.1007/978-3-540-24743-2_30 – volume: 17 start-page: 13 issue: 1 year: 1991 ident: 10.1016/j.jprocont.2010.10.003_bib17 article-title: Circadian variation of basal and postprandial insulin sensitivity in healthy individuals and patients with type-1 diabetes publication-title: Diabetes Res. – volume: 282 start-page: E992 issue: 5 year: 2002 ident: 10.1016/j.jprocont.2010.10.003_bib23 article-title: Partitioning glucose distribution/transport, disposal, and endogenous production during IVGTT publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00304.2001 – volume: 72 start-page: 1285 issue: 6 year: 1988 ident: 10.1016/j.jprocont.2010.10.003_bib46 article-title: The dietary treatment of diabetes mellitus publication-title: Med. Clin. North Am. doi: 10.1016/S0025-7125(16)30707-6 – volume: 53 start-page: 1478 issue: 8 year: 2006 ident: 10.1016/j.jprocont.2010.10.003_bib32 article-title: Model-based blood glucose control for type 1 diabetes via parametric programming publication-title: IEEE Trans. Biomed. Eng. doi: 10.1109/TBME.2006.878075 – volume: 48 start-page: 6059 issue: 13 year: 2009 ident: 10.1016/j.jprocont.2010.10.003_bib37 article-title: Practical approach to design and implementation of a control algorithm in an artificial pancreatic beta cell publication-title: Ind. Eng. Chem. Res. doi: 10.1021/ie801432u – volume: 11 start-page: 93 issue: 2 year: 2009 ident: 10.1016/j.jprocont.2010.10.003_bib48 article-title: Preventing hypoglycemia using predictive alarm algorithms and insulin pump suspension publication-title: Diabetes Technol. Ther. doi: 10.1089/dia.2008.0032 – volume: 65 start-page: S35 issue: Suppl 1 year: 2004 ident: 10.1016/j.jprocont.2010.10.003_bib19 article-title: Exercise-induced and other daytime hypoglycemic events in patients with diabetes: prevention and treatment publication-title: Diabetes Res. Clin. Pract. doi: 10.1016/j.diabres.2004.07.009 – volume: 145 start-page: 326 issue: 5 year: 2006 ident: 10.1016/j.jprocont.2010.10.003_bib55 article-title: Meal size, not body size, explains errors in estimating the calorie content of meals publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-145-5-200609050-00005 – volume: 38 start-page: 3 issue: 1 year: 2002 ident: 10.1016/j.jprocont.2010.10.003_bib30 article-title: The explicit linear quadratic regulator for constrained systems publication-title: Automatica doi: 10.1016/S0005-1098(01)00174-1 – volume: 21 start-page: 1870 issue: 11 year: 1998 ident: 10.1016/j.jprocont.2010.10.003_bib39 article-title: Assessment of risk for severe hypoglycemia among adults with IDDM: validation of the low blood glucose index publication-title: Diabetes Care doi: 10.2337/diacare.21.11.1870 – volume: 7 start-page: 28 issue: 1 year: 2005 ident: 10.1016/j.jprocont.2010.10.003_bib6 article-title: A critical assessment of algorithms and challenges in the development of a closed-loop artificial pancreas publication-title: Diabetes Technol. Ther. doi: 10.1089/dia.2005.7.28 – volume: 167 start-page: 1145 issue: 11 year: 2007 ident: 10.1016/j.jprocont.2010.10.003_bib1 article-title: Associations of diabetes mellitus with total life expectancy and life expectancy with and without cardiovascular disease publication-title: Arch. Intern. Med. doi: 10.1001/archinte.167.11.1145 – volume: 30 start-page: 93 issue: 2 year: 1983 ident: 10.1016/j.jprocont.2010.10.003_bib34 article-title: Evaluation of portal/peripheral route and of algorithms for insulin delivery in the closed-loop control of glucose in diabetes—a modeling study publication-title: IEEE Trans. Biomed. Eng. doi: 10.1109/TBME.1983.325203 – volume: 1 start-page: 284 year: 2004 ident: 10.1016/j.jprocont.2010.10.003_bib45 article-title: YALMIP: a toolbox for modeling and optimization in MATLAB publication-title: IEEE Int. Symp. Comp. Aided Contr. Syst. Des. – volume: 18 start-page: 258 issue: 3–4 year: 2008 ident: 10.1016/j.jprocont.2010.10.003_bib51 article-title: A run-to-run control strategy to adjust basal insulin infusion rates in type 1 diabetes publication-title: J. Process Control doi: 10.1016/j.jprocont.2007.07.010 – volume: 52 start-page: 147 issue: 3 year: 1997 ident: 10.1016/j.jprocont.2010.10.003_bib35 article-title: Estimation of endogenous glucose production after a glucose perturbation by nonparametric stochastic deconvolution publication-title: Comput. Methods Programs Biomed. doi: 10.1016/S0169-2607(96)01784-1 – volume: 28 start-page: 2481 issue: 12 year: 2004 ident: 10.1016/j.jprocont.2010.10.003_bib43 article-title: Explicit model predictive control of gas-liquid separation plant via orthogonal search tree partitioning publication-title: Comput. Chem. Eng. doi: 10.1016/j.compchemeng.2004.06.010 – volume: 49 start-page: 7843 issue: 17 year: 2010 ident: 10.1016/j.jprocont.2010.10.003_bib50 article-title: Automatic detection of stress states in type 1 diabetes subjects in ambulatory conditions publication-title: Ind. Eng. Chem. Res. doi: 10.1021/ie901891c – volume: 9 start-page: 438 issue: 5 year: 2007 ident: 10.1016/j.jprocont.2010.10.003_bib26 article-title: Practical issues in the identification of empirical models from simulated type 1 diabetes data publication-title: Diabetes Technol. Ther. doi: 10.1089/dia.2007.0202 – volume: 7 start-page: 48 issue: 1 year: 2005 ident: 10.1016/j.jprocont.2010.10.003_bib29 article-title: Run-to-run control of meal-related insulin dosing publication-title: Diabetes Technol. Ther. doi: 10.1089/dia.2005.7.48 – volume: 4 start-page: 295 issue: 3 year: 2002 ident: 10.1016/j.jprocont.2010.10.003_bib56 article-title: Methods for quantifying self-monitoring blood glucose profiles exemplified by an examination of blood glucose patterns in patients with type 1 and type 2 diabetes publication-title: Diabetes Technol. Ther. doi: 10.1089/152091502760098438 – volume: 52 start-page: 3 issue: 1 year: 2005 ident: 10.1016/j.jprocont.2010.10.003_bib24 article-title: Insulin kinetics in type-1 diabetes: continuous and bolus delivery of rapid acting insulin publication-title: IEEE Trans. Biomed. Eng. doi: 10.1109/TBME.2004.839639 |
| SSID | ssj0003726 |
| Score | 2.238813 |
| Snippet | A multi-parametric model predictive control (mpMPC) algorithm for subcutaneous insulin delivery for individuals with type 1 diabetes mellitus (T1DM) that is... |
| SourceID | pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 391 |
| SubjectTerms | Biomedical control Insulin delivery Multi-parametric model predictive control Type 1 diabetes mellitus |
| Title | Development of a multi-parametric model predictive control algorithm for insulin delivery in type 1 diabetes mellitus using clinical parameters |
| URI | https://dx.doi.org/10.1016/j.jprocont.2010.10.003 https://www.ncbi.nlm.nih.gov/pubmed/21516218 https://www.proquest.com/docview/1826167449 https://pubmed.ncbi.nlm.nih.gov/PMC3079204 |
| Volume | 21 |
| WOSCitedRecordID | wos000289389000009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1873-2771 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0003726 issn: 0959-1524 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Jb9NAFB6lLQc4sJQtLNUgIS6Rqe1xMp5jBSmLQuCQitwsz9imjhInZFP_BWf-LW9WuwtqOXCxooknY-t9896XN29B6DXntNuLIwH7O6QeWHzupaRbeJz6Mm0z5VSoIq4DOhzG4zH71mr9trkw2ymtqvjsjC3-q6hhDIQtU2f_QdzuR2EAPoPQ4Qpih-uNBN8IA9LJjypm0JM1vmeyfZbQ3W9kdYCsVNrOxaun0x_zZbk-nangQxumDjfL4A2VIKg8tkHtsZ3Jep7rzaqz0dm7Ns_SrGbC669gvwudoGCXrjX0UpRb1YSg86Xj_D_fjVfb8e4PYNyN79adGb1PZTeXOrsiq52zNpir4ZQERhE19XMYNHBIGsqW6D5fl4yA9kdM3k7kq8Bb6AA-FcNHarNnj_qHX5Pjk8EgGfXHozeLn55sSCYP7k13lh20F9IuA52_d_SpP_7szDyhqpefe-RG-vnVS_-N-Vz-Z3MxQLfBeEb30V0jLHykIfYAtfJqH92zbUCwsQr76E6jpuVD9KuBPzwvcIov4g8r_OEaf9iAADv8YcAfNvjDFn8wgCX-cIAt_rDFH1b4wxZ_uMbfI3Ry3B-9--iZrh-eAKK09ljq-znrpYJnsjZWFGeiB9a8y7LQZ6EoREbCnBMWcZ-lYR4B5y0yQgnhfhAXYU4eo91qXuVPEe7FRZ5x7scFEG-Yy1Og57yICaVBQEjURl0rkUSYkviyM8s0sbGPk8RKMpGSlOMgyTY6dPMWuijMtTOYFXhiqK2mrAmA9tq5ryxCEtD98kAvrfL5ZpVI34DMIopYGz3RiHHPI6l8D_h7G9FzWHI3yLry57-pylNVXx7MPgv96NkN1n2Obtf7-AXaXS83-Ut0S2zX5Wp5gHboOD4wG-cP9NH4qg |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Development+of+a+multi-parametric+model+predictive+control+algorithm+for+insulin+delivery+in+type+1+diabetes+mellitus+using+clinical+parameters&rft.jtitle=Journal+of+process+control&rft.au=Percival%2C+M+W&rft.au=Wang%2C+Y&rft.au=Grosman%2C+B&rft.au=Dassau%2C+E&rft.date=2011-03-01&rft.issn=0959-1524&rft.volume=21&rft.issue=3&rft.spage=391&rft_id=info:doi/10.1016%2Fj.jprocont.2010.10.003&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0959-1524&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0959-1524&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0959-1524&client=summon |