Mitochondrial DNA sequencing reveals association of variants and haplogroup M33a2′3 with High altitude pulmonary edema susceptibility in Indian male lowlanders
High Altitude Pulmonary Edema (HAPE) is a threatening disorder caused due to acute exposure to high altitude above 3000 m. Apart from multiple factors involved, the genetic factors also play an important function in the pathogenesis of HAPE. This study aims to evaluate the role of mtDNA polymorphism...
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| Abstract | High Altitude Pulmonary Edema (HAPE) is a threatening disorder caused due to acute exposure to high altitude above 3000 m. Apart from multiple factors involved, the genetic factors also play an important function in the pathogenesis of HAPE. This study aims to evaluate the role of mtDNA polymorphism and their association with haplogroup in understanding the etiology of HAPE. In this study, all the HAPE susceptible and acclimatized control subjects could be classified into nine haplogroups pertaining mostly to Macrohaplogroup M and U. The frequency of haplogroup M was significantly higher in HAPE susceptibles whereas the haplogroup M33a2′3 was found only in HAPE susceptibles. The variant G4491A and A4944G of MT-ND2, A14002G of MT-ND5, and C8562T of MT-ATP8, were definition site of haplogroup M33a2′3. The frequency of A10398G of MT-ND3, A8701G of MT-ATP6 and C14766T of MT-CYB genes were significantly higher in HAPE susceptibles. mtDNA copy number also plays a significant synergistic role in HAPE susceptibility. Our findings suggests that variants in MT-ND2 and MT-ND5 were predicted to confer decreased protein stability in HAPE susceptibles and in particular, highly conserved variants G4491A, A4944G and A14002G associated with haplogroup M33a2′3 may be the primary cause of susceptibility to HAPE in Indian male lowlanders. |
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| AbstractList | High Altitude Pulmonary Edema (HAPE) is a threatening disorder caused due to acute exposure to high altitude above 3000 m. Apart from multiple factors involved, the genetic factors also play an important function in the pathogenesis of HAPE. This study aims to evaluate the role of mtDNA polymorphism and their association with haplogroup in understanding the etiology of HAPE. In this study, all the HAPE susceptible and acclimatized control subjects could be classified into nine haplogroups pertaining mostly to Macrohaplogroup M and U. The frequency of haplogroup M was significantly higher in HAPE susceptibles whereas the haplogroup M33a2′3 was found only in HAPE susceptibles. The variant G4491A and A4944G of MT-ND2, A14002G of MT-ND5, and C8562T of MT-ATP8, were definition site of haplogroup M33a2′3. The frequency of A10398G of MT-ND3, A8701G of MT-ATP6 and C14766T of MT-CYB genes were significantly higher in HAPE susceptibles. mtDNA copy number also plays a significant synergistic role in HAPE susceptibility. Our findings suggests that variants in MT-ND2 and MT-ND5 were predicted to confer decreased protein stability in HAPE susceptibles and in particular, highly conserved variants G4491A, A4944G and A14002G associated with haplogroup M33a2′3 may be the primary cause of susceptibility to HAPE in Indian male lowlanders. |
| ArticleNumber | 10975 |
| Author | Ganju, Lilly Singh, Shashi Bala Singh, Yamini Kumar, Bhuvnesh Sharma, Swati Singh, Sayar Gupta, Rajinder K. |
| Author_xml | – sequence: 1 givenname: Swati surname: Sharma fullname: Sharma, Swati organization: Defence Institute of Physiology and Allied Sciences, Timarpur – sequence: 2 givenname: Sayar surname: Singh fullname: Singh, Sayar organization: Defence Institute of Physiology and Allied Sciences, Timarpur – sequence: 3 givenname: Rajinder K. surname: Gupta fullname: Gupta, Rajinder K. organization: Defence Institute of Physiology and Allied Sciences, Timarpur – sequence: 4 givenname: Lilly surname: Ganju fullname: Ganju, Lilly organization: Defence Institute of Physiology and Allied Sciences, Timarpur – sequence: 5 givenname: Shashi Bala surname: Singh fullname: Singh, Shashi Bala organization: NIPER, Hyderabad, Balanagar – sequence: 6 givenname: Bhuvnesh surname: Kumar fullname: Kumar, Bhuvnesh organization: Defence Institute of Physiology and Allied Sciences, Timarpur – sequence: 7 givenname: Yamini surname: Singh fullname: Singh, Yamini email: yamini29@gmail.com organization: Defence Institute of Physiology and Allied Sciences, Timarpur |
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| CitedBy_id | crossref_primary_10_1016_j_mito_2021_10_010 crossref_primary_10_1038_s41598_020_80271_8 crossref_primary_10_1016_j_bbabio_2021_148431 crossref_primary_10_1186_s12890_021_01791_1 crossref_primary_10_3389_fphar_2025_1644436 crossref_primary_10_3233_JAD_221136 crossref_primary_10_3354_meps13735 |
| Cites_doi | 10.1146/annurev.bi.65.070196.003023 10.1212/01.wnl.0000196490.36349.83 10.1038/srep26468 10.4238/2012.October.9.1 10.1146/annurev.genet.39.110304.095751 10.1038/27103 10.1371/journal.pone.0079536 10.1093/nar/gkl927 10.1093/nar/gkn1027 10.1186/1471-2148-5-26 10.1146/annurev.biochem.75.103004.142539 10.1186/1471-2164-7-151 10.1002/ana.10787 10.1093/hmg/dds435 10.1038/jhg.2016.95 10.1093/molbev/msj078 10.1007/PL00006412 10.1371/journal.pgen.0020128 10.1016/j.gene.2011.12.016 10.1101/sqb.2003.68.479 10.1371/journal.pone.0001141 10.1007/s00439-006-0269-z 10.1016/j.wem.2012.02.003 10.1126/science.283.5407.1488 10.1101/gr.1413403 10.1002/ajmg.1397 10.3109/19401736.2012.760558 10.1093/molbev/msg121 10.1146/annurev.pathol.4.110807.092314 10.1016/S0960-9822(00)80057-3 10.1016/0300-9629(86)90429-9 10.1016/S0378-1119(99)00295-4 10.1126/science.270.5244.1930 10.1186/1476-4598-3-19 10.1101/gr.GR-1733RR 10.1016/j.redox.2017.02.012 10.1186/1471-2156-5-26 10.1016/j.febslet.2014.05.054 10.3109/19401736.2011.588221 10.1186/1471-2164-9-119 10.1113/jphysiol.2003.049478 10.1016/j.mito.2011.08.002 10.3109/19401736.2011.632771 10.1038/s41392-018-0011-z 10.1101/sqb.2009.74.031 10.3389/fgene.2018.00605 10.1002/em.20586 10.1016/j.lfs.2011.05.010 10.1016/S0092-8674(00)80611-X 10.1095/biolreprod.102.005140 10.1136/emj.2008.065060 |
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| References | Wallace, Brown, Lott (CR45) 1999; 30 Ayala (CR16) 1995; 270 McFarland, Kirby, Fowler, Ohtake, Ryan, Amor, Fletcher, Dixon, Collins, Turnbull, Taylor, Thorburn (CR52) 2003; 55 Cawthon (CR22) 2009; 37 Xiacheng, Lei (CR54) 2018; 3 Nishigaki (CR20) 2007; 120 Mingliang (CR40) 2012; 496 Moilanen (CR42) 2003; 20 Metspalu (CR32) 2004; 5 CR37 Ruiz-Pesini (CR4) 2007; 35 Luo (CR8) 2012; 23 Luo, Gao, Li (CR10) 2012; 11 Basu (CR29) 2003; 13 Douglas (CR12) 2005; 39 Kazuno (CR61) 2006; 2 Xia (CR38) 1998; 47 Thangaraj (CR30) 2006; 7 CR9 Gregg (CR57) 2012; 148 Poyton (CR55) 1996; 65 Wallace (CR39) 1999; 238 Yoshino (CR14) 1986; 85 CR46 Wallace (CR2) 2010; 51 Sun (CR31) 2006; 23 McFarland (CR48) 2004; 55 Payne (CR43) 2013; 22 Luo, Chen, Liu, Jiang, Gao (CR17) 2011; 22 Luo, Yang, Gao (CR24) 2013; 24 Qian Li (CR11) 2016; 61 Reddy (CR34) 2007; 2 Luo, Gao, Chen, Liu, Gao (CR19) 2012; 23 Brandt (CR35) 2006; 75 Crimi, Rigolio (CR1) 2008; 3 CR53 Roychoudhury (CR25) 2000; 79 CR50 Gisela (CR18) 2011; 11 Saraste (CR5) 1999; 283 Luo (CR21) 2011; 22 Rajkumar (CR26) 2005; 5 Bamshad (CR28) 1998; 11 Triepels, Van Den Heuvel, Trijbels, Smeitink (CR47) 2001; 106 Turrens (CR58) 2003; 552 DeHaan (CR41) 2004; 3 Wallace (CR3) 2009; 74 Dominik (CR13) 2017; 12 Swalwell, Deschauer (CR49) 2006; 66 Wallace, Ruiz-Pesini, Mishmar (CR15) 2003; 68 Suvendumaji, Krithika, Vasulu (CR33) 2009; 88 Yao-Ting (CR56) 2013; 8 Bamshad, Watkins, Dixon, Jorde, Rao, Naidu, Prasad, Rasanayagam, Hammer (CR27) 1998; 395 Lightowlers, Rozanska, Chrzanowska-Lightowlers (CR6) 2014; 588 Poonam (CR59) 2016; 6 CR60 Kivisild (CR23) 1999; 9 Moraes (CR51) 2001; 106 Rute (CR36) 2008; 9 Ruiz-Pesini (CR7) 2007; 35 Wallace, Fan, Procaccio (CR44) 2010; 5 Nishigaki (47500_CR20) 2007; 120 H Swalwell (47500_CR49) 2006; 66 Basu (47500_CR29) 2003; 13 Qian Li (47500_CR11) 2016; 61 C Dominik (47500_CR13) 2017; 12 47500_CR37 G Mingliang (47500_CR40) 2012; 496 Robert McFarland (47500_CR52) 2003; 55 C Douglas (47500_CR12) 2005; 39 Yongjun Luo (47500_CR24) 2013; 24 47500_CR46 DC Wallace (47500_CR2) 2010; 51 S Poonam (47500_CR59) 2016; 6 C Yao-Ting (47500_CR56) 2013; 8 R McFarland (47500_CR48) 2004; 55 DC Wallace (47500_CR39) 1999; 238 BA Payne (47500_CR43) 2013; 22 Ruiz-Pesini (47500_CR7) 2007; 35 Moraes (47500_CR51) 2001; 106 DC Wallace (47500_CR44) 2010; 5 DC Wallace (47500_CR15) 2003; 68 Thangaraj (47500_CR30) 2006; 7 AA Kazuno (47500_CR61) 2006; 2 N Gisela (47500_CR18) 2011; 11 C DeHaan (47500_CR41) 2004; 3 L Gregg (47500_CR57) 2012; 148 R. M. Cawthon (47500_CR22) 2009; 37 JF Turrens (47500_CR58) 2003; 552 Y Luo (47500_CR19) 2012; 23 Reddy (47500_CR34) 2007; 2 R Rute (47500_CR36) 2008; 9 DC Wallace (47500_CR3) 2009; 74 Poyton (47500_CR55) 1996; 65 S Suvendumaji (47500_CR33) 2009; 88 E Ruiz-Pesini (47500_CR4) 2007; 35 YJ Luo (47500_CR10) 2012; 11 Metspalu (47500_CR32) 2004; 5 RH Triepels (47500_CR47) 2001; 106 C Sun (47500_CR31) 2006; 23 JS Moilanen (47500_CR42) 2003; 20 RN Lightowlers (47500_CR6) 2014; 588 47500_CR9 S Xiacheng (47500_CR54) 2018; 3 Rajkumar (47500_CR26) 2005; 5 FJ Ayala (47500_CR16) 1995; 270 47500_CR60 Y Luo (47500_CR8) 2012; 23 Y Luo (47500_CR17) 2011; 22 Bamshad (47500_CR28) 1998; 11 U Brandt (47500_CR35) 2006; 75 DC Wallace (47500_CR45) 1999; 30 Yoshino (47500_CR14) 1986; 85 Y Luo (47500_CR21) 2011; 22 Michael J. Bamshad (47500_CR27) 1998; 395 M Crimi (47500_CR1) 2008; 3 47500_CR53 Kivisild (47500_CR23) 1999; 9 Roychoudhury (47500_CR25) 2000; 79 X Xia (47500_CR38) 1998; 47 M Saraste (47500_CR5) 1999; 283 47500_CR50 |
| References_xml | – volume: 65 start-page: 563 year: 1996 end-page: 607 ident: CR55 article-title: Cross talk between nuclear and mitochondrial genome publication-title: Annual Review of Biochemistry doi: 10.1146/annurev.bi.65.070196.003023 – volume: 88, start-page: xx year: 2009 end-page: xx ident: CR33 article-title: *Phylogeographic distribution of mitochondrial DNA macrohaplogroup M in India publication-title: J. Genet. – volume: 3 start-page: 51 year: 2008 end-page: 57 ident: CR1 article-title: The mitochondrial genome, a growing interest inside an organelle publication-title: Int J Nanomedicine – volume: 66 start-page: 447 year: 2006 end-page: 449 ident: CR49 article-title: Pure myopathy associated with a novel mitochondrial tRNA gene mutation publication-title: Neurology doi: 10.1212/01.wnl.0000196490.36349.83 – volume: 6 year: 2016 ident: CR59 article-title: Raised HIF1 alpha during high altitude pulmonary edema susceptible non-mountaineers publication-title: Scientific Reports doi: 10.1038/srep26468 – volume: 11 start-page: 3658 issue: 4 year: 2012 end-page: 3667 ident: CR10 article-title: Mitochondrial Haplogroup D4 confers resisatnmce and haplogroup B is a genetic risk factor for high-altitude pulmonary edema among Han Chinese publication-title: Genetics and olecular Research doi: 10.4238/2012.October.9.1 – volume: 39 start-page: 359 year: 2005 ident: CR12 article-title: Wallace. A mitochondrial paradigm of metabolic and degenerative diseases, aging and Cancer: A drawn for evolutionary medicine publication-title: Annu Rev Genet doi: 10.1146/annurev.genet.39.110304.095751 – volume: 395 start-page: 651 issue: 6703 year: 1998 end-page: 652 ident: CR27 article-title: Female gene flow stratifies Hindu castes publication-title: Nature doi: 10.1038/27103 – ident: CR46 – volume: 8 start-page: e79536 issue: 11 year: 2013 ident: CR56 article-title: Mitochondrial DNA content contributes to climate adaptation using chinease populations as a modal publication-title: Plos One doi: 10.1371/journal.pone.0079536 – volume: 35 start-page: D823 year: 2007 end-page: D828 ident: CR4 article-title: An enhanced MITOMAP with a global mtDNA mutationalphylogeny publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkl927 – volume: 37 start-page: e21 issue: 3 year: 2009 end-page: e21 ident: CR22 article-title: Telomere length measurement by a novel monochrome multiplex quantitative PCR method publication-title: Nucleic Acids Research doi: 10.1093/nar/gkn1027 – volume: 5 year: 2005 ident: CR26 article-title: Phylogeny and antiquity of Mmacrohaplogroup infereed from complete mtDNA sequence of Indian specific lineages publication-title: BMC Evolutionary Biology. doi: 10.1186/1471-2148-5-26 – volume: 75 start-page: 69 year: 2006 end-page: 92 ident: CR35 article-title: Energy converting NADH:quinine oxidoreductase (Complex I) publication-title: Annual Rev Biochem doi: 10.1146/annurev.biochem.75.103004.142539 – ident: CR50 – volume: 7 year: 2006 ident: CR30 article-title: origin of deep rooting lineages of mitochondrial haplogroup M in India publication-title: BMC Genomics doi: 10.1186/1471-2164-7-151 – volume: 55 start-page: 58 year: 2004 end-page: 64 ident: CR48 article-title: De novo mutations in the mitochondrial ND3 gene as a cause of infantile mitochondrial encephalopathy and complex I deficiency publication-title: Ann Neurol. doi: 10.1002/ana.10787 – ident: CR9 – volume: 22 start-page: 384 issue: 2 year: 2013 end-page: 90 ident: CR43 article-title: Universal heteroplasmy of human mitochondrial DNA publication-title: Hum Mol Genet. doi: 10.1093/hmg/dds435 – ident: CR60 – volume: 61 start-page: 1021 year: 2016 end-page: 1026 ident: CR11 article-title: Mitochondrial haplogroup M9a1a1c1b is associated with hypoxic adaptation in the Tibetans publication-title: Journal of Human Genetics doi: 10.1038/jhg.2016.95 – volume: 55 start-page: 58 issue: 1 year: 2003 end-page: 64 ident: CR52 article-title: De novo mutations in the mitochondrialND3 gene as a cause of infantile mitochondrial encephalopathy and complex I deficiency publication-title: Annals of Neurology doi: 10.1002/ana.10787 – volume: 23 start-page: 683 year: 2006 end-page: 690 ident: CR31 article-title: Thedazzling array of basal branches in the mtDNA macrohaplogroup M from Indians inferred from complete genomes publication-title: Mol Biol Evol doi: 10.1093/molbev/msj078 – volume: 47 start-page: 557 year: 1998 end-page: 564 ident: CR38 article-title: What amino acid properties affect protein evolution? publication-title: J. Mol. Evol. doi: 10.1007/PL00006412 – volume: 2 start-page: e128 issue: 8 year: 2006 ident: CR61 article-title: Identification of mitochondrial DNA polymorphisms that alter mitochondrial matrix pH and intracellular calcium dynamics publication-title: PLoS Genet. Aug doi: 10.1371/journal.pgen.0020128 – volume: 496 start-page: 37 year: 2012 end-page: 44 ident: CR40 article-title: Differences in mtDNA whole sequence between Tibetan and Han populations suggesting adaptive selection to high altitude publication-title: Gene doi: 10.1016/j.gene.2011.12.016 – volume: 68 start-page: 479 year: 2003 end-page: 86 ident: CR15 article-title: mtDNA variation, climatic adaptation, degenerative diseases, and longevity publication-title: Cold SpringHarbSymp Quant Biol doi: 10.1101/sqb.2003.68.479 – volume: 148 start-page: 399 issue: 3 year: 2012 end-page: 408 ident: CR57 article-title: Hypoxia –Inducible factors in Physiology and Medicine publication-title: National Institute of Health – volume: 2 start-page: e1141 year: 2007 ident: CR34 article-title: Austro-Asiatic tribes of northeast India provide hitherto missing genetic link between south and south-east Asia publication-title: PloS One doi: 10.1371/journal.pone.0001141 – volume: 120 start-page: 827 year: 2007 end-page: 836 ident: CR20 article-title: Mitochondrial haplogroup N9b is protective against myocardial infarction in japanese males publication-title: Human Genetics doi: 10.1007/s00439-006-0269-z – volume: 23 start-page: 128 year: 2012 end-page: 32 ident: CR19 article-title: Rare mitochondrial DNA polymorphisms are associated with high altitude pulmonary edema(HAPE) susceptibility in Han Chinese publication-title: Wilderness Environ Med doi: 10.1016/j.wem.2012.02.003 – volume: 23 start-page: 128 year: 2012 end-page: 132 ident: CR8 article-title: Rare mitochondrial DNA polymorphism are associated with High altitude Pulmonary Edema(HAPE) susceptibility in Han Chinease publication-title: Wilderness & Environmental Medicine doi: 10.1016/j.wem.2012.02.003 – ident: CR37 – ident: CR53 – volume: 283 start-page: 1488 year: 1999 end-page: 1493 ident: CR5 article-title: Oxidative phosphorylation at the fin de siècle publication-title: Science doi: 10.1126/science.283.5407.1488 – volume: 13 start-page: 2277 year: 2003 end-page: 2290 ident: CR29 article-title: Ethnic India: a genomic view, with special reference to peopling and structure publication-title: Genome Research doi: 10.1101/gr.1413403 – volume: 106 start-page: 37 year: 2001 end-page: 45 ident: CR47 article-title: Respiratory chain complex I deficiency publication-title: Am J Med Genet. doi: 10.1002/ajmg.1397 – volume: 106 start-page: 37 year: 2001 end-page: 45 ident: CR51 article-title: mtDNA depletion with variable tissue: a novel genetic abnormality in mitochondrial diseases. American Journal of Human Genetics Triepels RH, Van Den Heuvel LP, Trijbels JM, Smeitink JA. Respiratory chain complex I deficiency publication-title: Am J Med Genet. doi: 10.1002/ajmg.1397 – volume: 24 start-page: 313 issue: 4 year: 2013 end-page: 319 ident: CR24 article-title: Mitochondrial DNA response to high altitude: A new perspective on high-altitude adaptation publication-title: Mitochondrial DNA doi: 10.3109/19401736.2012.760558 – volume: 20 start-page: 1195 year: 2003 end-page: 1210 ident: CR42 article-title: Phylogenetic network and physicochemical properties of nonsynonymous mutations in the protein coding genes of human mitochondrial DNA publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/msg121 – volume: 5 start-page: 297 year: 2010 end-page: 348 ident: CR44 article-title: Mitochondrial energetics and therapeutics publication-title: Annu Rev Pathol. doi: 10.1146/annurev.pathol.4.110807.092314 – volume: 9 start-page: 1331 year: 1999 end-page: 1334 ident: CR23 article-title: Deep common ancestory of Indian and western – Eurasian mitochondrial DNA lineages publication-title: Current Biology. doi: 10.1016/S0960-9822(00)80057-3 – volume: 85 start-page: 455 year: 1986 end-page: 457 ident: CR14 article-title: Changes in plasma phosphate with the stimulation of anaerobic metabolism in rats during hypoxic-anoxic states publication-title: Comp. mBiochem. Physiol. A Comp. Physiol. doi: 10.1016/0300-9629(86)90429-9 – volume: 238 start-page: 211 year: 1999 end-page: 230 ident: CR39 article-title: Mitochondrial DNA variation in human evolution and disease publication-title: Gene doi: 10.1016/S0378-1119(99)00295-4 – volume: 30 start-page: 211 issue: 238(1) year: 1999 end-page: 30 ident: CR45 article-title: Mitochondrial DNA variation in human evolution and disease publication-title: Gene. Sep doi: 10.1016/S0378-1119(99)00295-4 – volume: 270 start-page: 1930 year: 1995 end-page: 1936 ident: CR16 article-title: The myth of Eve: molecular biology and human origins publication-title: Science doi: 10.1126/science.270.5244.1930 – volume: 3 year: 2004 ident: CR41 article-title: Mutation in mitochondrial Complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells publication-title: Molecular Cancer doi: 10.1186/1476-4598-3-19 – volume: 35 start-page: D823 year: 2007 end-page: D828 ident: CR7 article-title: An enhances MITOMAP with a global mtDNA mutational phylogeny publication-title: Nucleic Acid Res. doi: 10.1093/nar/gkl927 – volume: 11 start-page: 994 year: 1998 end-page: 1004 ident: CR28 article-title: 2001 Genetic evidence on the origin of Indian caste populations publication-title: Genome Research doi: 10.1101/gr.GR-1733RR – volume: 12 start-page: 208 year: 2017 end-page: 215 ident: CR13 article-title: Mitochondrial composition and function under the control of hypoxia publication-title: Redox Biology doi: 10.1016/j.redox.2017.02.012 – volume: 5 year: 2004 ident: CR32 article-title: Most of the extant mtDNA boundaries in South and Southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans publication-title: BMC Genetics doi: 10.1186/1471-2156-5-26 – volume: 51 start-page: 440 year: 2010 end-page: 450 ident: CR2 article-title: Mitochondrial DNA mutations in disease and aging publication-title: Environ Mol Mutagen – volume: 588 start-page: 2496 year: 2014 end-page: 2503 ident: CR6 article-title: Mitochondrial protein synthesis: figuring the fundamentals, complexities and complications, of mammalian mitochondrial translation publication-title: FEBS Lett doi: 10.1016/j.febslet.2014.05.054 – volume: 22 start-page: 6 year: 2011 end-page: 8 ident: CR17 article-title: Mitochondrial genome sequence of the Tibetan wild ass (Equus kiang) publication-title: Mitochondrial DNA doi: 10.3109/19401736.2011.588221 – volume: 9 year: 2008 ident: CR36 article-title: The adaptive evolution of mammalian mitochondrial genome publication-title: BMC Genomics doi: 10.1186/1471-2164-9-119 – volume: 552 start-page: 335 year: 2003 end-page: 344 ident: CR58 article-title: Mitochondrial formation of reactive oxygen species publication-title: J Physiol doi: 10.1113/jphysiol.2003.049478 – volume: 11 start-page: 905 year: 2011 end-page: 908 ident: CR18 article-title: Are mitochondrial haplogroups associated with elite status? A study on a Spanish cohort publication-title: Mitochondrion doi: 10.1016/j.mito.2011.08.002 – volume: 22 start-page: 181 year: 2011 end-page: 190 ident: CR21 article-title: Mitochondrial nt3010G-nt3970C haplotype is implicated in high altitude adaptation of Tibetans publication-title: Mitochondrial DNA doi: 10.3109/19401736.2011.632771 – volume: 79 start-page: 1182 year: 2000 end-page: 1192 ident: CR25 article-title: Fundamental genomic unity of ethnic India is revealed by analysis of mitochondrial DNA publication-title: Current Science – volume: 3 start-page: 8 year: 2018 ident: CR54 article-title: Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer publication-title: Signal Transduction and Targeted Therapy doi: 10.1038/s41392-018-0011-z – volume: 74 start-page: 383 year: 2009 end-page: 393 ident: CR3 article-title: Mitochondria, bioenergetics, and the epigenome in eukaryotic and human evolution publication-title: Cold Spring HarbSymp Quant Biol doi: 10.1101/sqb.2009.74.031 – volume: 23 start-page: 128 year: 2012 ident: 47500_CR8 publication-title: Wilderness & Environmental Medicine doi: 10.1016/j.wem.2012.02.003 – volume: 588 start-page: 2496 year: 2014 ident: 47500_CR6 publication-title: FEBS Lett doi: 10.1016/j.febslet.2014.05.054 – volume: 75 start-page: 69 year: 2006 ident: 47500_CR35 publication-title: Annual Rev Biochem doi: 10.1146/annurev.biochem.75.103004.142539 – volume: 106 start-page: 37 year: 2001 ident: 47500_CR51 publication-title: Am J Med Genet. doi: 10.1002/ajmg.1397 – volume: 22 start-page: 181 year: 2011 ident: 47500_CR21 publication-title: Mitochondrial DNA doi: 10.3109/19401736.2011.632771 – volume: 24 start-page: 313 issue: 4 year: 2013 ident: 47500_CR24 publication-title: Mitochondrial DNA doi: 10.3109/19401736.2012.760558 – volume: 552 start-page: 335 year: 2003 ident: 47500_CR58 publication-title: J Physiol doi: 10.1113/jphysiol.2003.049478 – volume: 35 start-page: D823 year: 2007 ident: 47500_CR7 publication-title: Nucleic Acid Res. doi: 10.1093/nar/gkl927 – volume: 74 start-page: 383 year: 2009 ident: 47500_CR3 publication-title: Cold Spring HarbSymp Quant Biol doi: 10.1101/sqb.2009.74.031 – volume: 37 start-page: e21 issue: 3 year: 2009 ident: 47500_CR22 publication-title: Nucleic Acids Research doi: 10.1093/nar/gkn1027 – volume: 106 start-page: 37 year: 2001 ident: 47500_CR47 publication-title: Am J Med Genet. doi: 10.1002/ajmg.1397 – volume: 11 start-page: 3658 issue: 4 year: 2012 ident: 47500_CR10 publication-title: Genetics and olecular Research doi: 10.4238/2012.October.9.1 – volume: 496 start-page: 37 year: 2012 ident: 47500_CR40 publication-title: Gene doi: 10.1016/j.gene.2011.12.016 – volume: 12 start-page: 208 year: 2017 ident: 47500_CR13 publication-title: Redox Biology doi: 10.1016/j.redox.2017.02.012 – volume: 23 start-page: 683 year: 2006 ident: 47500_CR31 publication-title: Mol Biol Evol doi: 10.1093/molbev/msj078 – volume: 7 year: 2006 ident: 47500_CR30 publication-title: BMC Genomics doi: 10.1186/1471-2164-7-151 – volume: 39 start-page: 359 year: 2005 ident: 47500_CR12 publication-title: Annu Rev Genet doi: 10.1146/annurev.genet.39.110304.095751 – volume: 11 start-page: 994 year: 1998 ident: 47500_CR28 publication-title: Genome Research doi: 10.1101/gr.GR-1733RR – volume: 23 start-page: 128 year: 2012 ident: 47500_CR19 publication-title: Wilderness Environ Med doi: 10.1016/j.wem.2012.02.003 – volume: 66 start-page: 447 year: 2006 ident: 47500_CR49 publication-title: Neurology doi: 10.1212/01.wnl.0000196490.36349.83 – volume: 35 start-page: D823 year: 2007 ident: 47500_CR4 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkl927 – volume: 20 start-page: 1195 year: 2003 ident: 47500_CR42 publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/msg121 – volume: 148 start-page: 399 issue: 3 year: 2012 ident: 47500_CR57 publication-title: National Institute of Health – volume: 88, start-page: xx year: 2009 ident: 47500_CR33 publication-title: J. Genet. – volume: 3 start-page: 8 year: 2018 ident: 47500_CR54 publication-title: Signal Transduction and Targeted Therapy doi: 10.1038/s41392-018-0011-z – volume: 9 year: 2008 ident: 47500_CR36 publication-title: BMC Genomics doi: 10.1186/1471-2164-9-119 – volume: 395 start-page: 651 issue: 6703 year: 1998 ident: 47500_CR27 publication-title: Nature doi: 10.1038/27103 – volume: 85 start-page: 455 year: 1986 ident: 47500_CR14 publication-title: Comp. mBiochem. Physiol. A Comp. Physiol. doi: 10.1016/0300-9629(86)90429-9 – volume: 5 year: 2004 ident: 47500_CR32 publication-title: BMC Genetics doi: 10.1186/1471-2156-5-26 – volume: 3 start-page: 51 year: 2008 ident: 47500_CR1 publication-title: Int J Nanomedicine – ident: 47500_CR37 doi: 10.3389/fgene.2018.00605 – volume: 22 start-page: 384 issue: 2 year: 2013 ident: 47500_CR43 publication-title: Hum Mol Genet. doi: 10.1093/hmg/dds435 – volume: 6 year: 2016 ident: 47500_CR59 publication-title: Scientific Reports doi: 10.1038/srep26468 – volume: 22 start-page: 6 year: 2011 ident: 47500_CR17 publication-title: Mitochondrial DNA doi: 10.3109/19401736.2011.588221 – ident: 47500_CR9 – volume: 65 start-page: 563 year: 1996 ident: 47500_CR55 publication-title: Annual Review of Biochemistry doi: 10.1146/annurev.bi.65.070196.003023 – volume: 51 start-page: 440 year: 2010 ident: 47500_CR2 publication-title: Environ Mol Mutagen doi: 10.1002/em.20586 – ident: 47500_CR53 doi: 10.1016/j.lfs.2011.05.010 – volume: 283 start-page: 1488 year: 1999 ident: 47500_CR5 publication-title: Science doi: 10.1126/science.283.5407.1488 – volume: 270 start-page: 1930 year: 1995 ident: 47500_CR16 publication-title: Science doi: 10.1126/science.270.5244.1930 – volume: 238 start-page: 211 year: 1999 ident: 47500_CR39 publication-title: Gene doi: 10.1016/S0378-1119(99)00295-4 – ident: 47500_CR50 doi: 10.1016/S0092-8674(00)80611-X – ident: 47500_CR46 doi: 10.1095/biolreprod.102.005140 – volume: 5 year: 2005 ident: 47500_CR26 publication-title: BMC Evolutionary Biology. doi: 10.1186/1471-2148-5-26 – volume: 8 start-page: e79536 issue: 11 year: 2013 ident: 47500_CR56 publication-title: Plos One doi: 10.1371/journal.pone.0079536 – volume: 55 start-page: 58 year: 2004 ident: 47500_CR48 publication-title: Ann Neurol. doi: 10.1002/ana.10787 – ident: 47500_CR60 doi: 10.1136/emj.2008.065060 – volume: 13 start-page: 2277 year: 2003 ident: 47500_CR29 publication-title: Genome Research doi: 10.1101/gr.1413403 – volume: 120 start-page: 827 year: 2007 ident: 47500_CR20 publication-title: Human Genetics doi: 10.1007/s00439-006-0269-z – volume: 30 start-page: 211 issue: 238(1) year: 1999 ident: 47500_CR45 publication-title: Gene. Sep doi: 10.1016/S0378-1119(99)00295-4 – volume: 11 start-page: 905 year: 2011 ident: 47500_CR18 publication-title: Mitochondrion doi: 10.1016/j.mito.2011.08.002 – volume: 5 start-page: 297 year: 2010 ident: 47500_CR44 publication-title: Annu Rev Pathol. doi: 10.1146/annurev.pathol.4.110807.092314 – volume: 47 start-page: 557 year: 1998 ident: 47500_CR38 publication-title: J. Mol. Evol. doi: 10.1007/PL00006412 – volume: 55 start-page: 58 issue: 1 year: 2003 ident: 47500_CR52 publication-title: Annals of Neurology doi: 10.1002/ana.10787 – volume: 2 start-page: e128 issue: 8 year: 2006 ident: 47500_CR61 publication-title: PLoS Genet. Aug doi: 10.1371/journal.pgen.0020128 – volume: 68 start-page: 479 year: 2003 ident: 47500_CR15 publication-title: Cold SpringHarbSymp Quant Biol doi: 10.1101/sqb.2003.68.479 – volume: 79 start-page: 1182 year: 2000 ident: 47500_CR25 publication-title: Current Science – volume: 2 start-page: e1141 year: 2007 ident: 47500_CR34 publication-title: PloS One doi: 10.1371/journal.pone.0001141 – volume: 61 start-page: 1021 year: 2016 ident: 47500_CR11 publication-title: Journal of Human Genetics doi: 10.1038/jhg.2016.95 – volume: 9 start-page: 1331 year: 1999 ident: 47500_CR23 publication-title: Current Biology. doi: 10.1016/S0960-9822(00)80057-3 – volume: 3 year: 2004 ident: 47500_CR41 publication-title: Molecular Cancer doi: 10.1186/1476-4598-3-19 |
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| SubjectTerms | 45 45/22 45/23 45/29 45/77 631/208/205 631/208/726/2129 Altitude Copy number DNA sequencing Edema Etiology Genetic factors High-altitude environments Humanities and Social Sciences Mitochondrial DNA multidisciplinary Science Science (multidisciplinary) |
| Title | Mitochondrial DNA sequencing reveals association of variants and haplogroup M33a2′3 with High altitude pulmonary edema susceptibility in Indian male lowlanders |
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