Alcohol intake stimulates epithelial proliferation in an authentic model of the human breast

•The mammary glands of pigs can be used to model alcohol effects on the breast.•Alcohol intake stimulates epithelial proliferation in the mammary gland.•Alcohol intake promotes histomorphogenic changes and STAT5 phosphorylation. The voluntary consumption of alcohol by humans is a modifiable lifestyl...

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Bibliographic Details
Published in:	Reproductive toxicology (Elmsford, N.Y.) Vol. 54; pp. 93 - 100
Main Authors:	Schennink, Anke, Trott, Josephine F., Berryhill, Grace E., Donovan, Caitlin E., Manjarin, Rodrigo, VanKlompenberg, Monica K., Rowson-Hodel, Ashley R., Luis, Michelle-Yvette Osorio, Hovey, Russell C.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.07.2015
Subjects:	Age Factors Alcohol Alcohol Drinking - adverse effects Animals Breast Neoplasms - chemically induced Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Proliferation - drug effects Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Ethanol - blood Ethanol - toxicity Female Humans Mammary gland Mammary Glands, Animal - drug effects Mammary Glands, Animal - growth & development Mammary Glands, Animal - metabolism Mammary Glands, Animal - pathology Models, Animal Phosphorylation Risk Assessment Risk Factors Sexual Development STAT5 Transcription Factor - metabolism Swine Terminal ductal lobular unit P-Stat5 IGF-I PR DAB BAC IGFBP3 Alcohol PH3 MG Mammary gland Terminal ductal lobular unit TDLU
ISSN:	0890-6238, 1873-1708, 1873-1708
Online Access:	Get full text
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