PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis

Despite growing importance of long non-coding RNAs (lncRNAs) in normal physiological and disease conditions, our knowledge of RA-related lncRNAs remains limited. Therefore, we aimed to identify lncRNA signatures that have prognostic values in RA. There was a notably high expression level of Hotair i...

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Vydáno v:Clinical and experimental medicine Ročník 15; číslo 1; s. 121 - 126
Hlavní autoři: Song, Jinsoo, Kim, Dongkyun, Han, Jiyeon, Kim, Yunha, Lee, Myeungsu, Jin, Eun-Jung
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cham Springer International Publishing 01.02.2015
Springer Nature B.V
Témata:
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - pathology
Biomarkers
Biomarkers - metabolism
Chemotaxis
Exosomes - chemistry
Exosomes - metabolism
Gene Expression
Hematology
Humans
Internal Medicine
Leukocytes, Mononuclear - metabolism
Leukocytes, Mononuclear - pathology
Macrophages - metabolism
Macrophages - pathology
Matrix Metalloproteinase 13 - genetics
Matrix Metalloproteinase 13 - metabolism
Matrix Metalloproteinase 2 - genetics
Matrix Metalloproteinase 2 - metabolism
Medicine
Medicine & Public Health
Oncology
Osteoclasts - metabolism
Osteoclasts - pathology
Primary Cell Culture
Rheumatoid arthritis
Ribonucleic acid
RNA
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Short Communication
Synovial Fluid - chemistry
Synovial Fluid - metabolism
Synovial Membrane - metabolism
Synovial Membrane - pathology
U937 Cells
LncRNA
Matrix metalloprotease
Hotair
BMCS
Exosome
Rheumatoid arthritis
ISSN:1591-9528, 1591-8890, 1591-9528
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Popis
Shrnutí:Despite growing importance of long non-coding RNAs (lncRNAs) in normal physiological and disease conditions, our knowledge of RA-related lncRNAs remains limited. Therefore, we aimed to identify lncRNA signatures that have prognostic values in RA. There was a notably high expression level of Hotair in blood mononuclear cells and serum exosome of rheumatoid arthritis (RA) patients, leading the migration of active macrophage. In contrast, markedly lower level of Hotair was detected in differentiated osteoclasts and rheumatoid synoviocytes and enforced expression of Hotair led to significantly decreased levels of MMP-2 and MMP-13. This exploratory study provides novel empirical evidence that Hotair could be one of potential biomarkers for diagnosing RA.
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ISSN:1591-9528
1591-8890
1591-9528
DOI:10.1007/s10238-013-0271-4