Clinical Relevance of Serum Aquaporin-4 Antibody Levels in Neuromyelitis Optica
Neuromyelitis optica (NMO) is an inflammatory disease that selectively affects the optic nerves and spinal cord. The discovery of NMO-IgG targeting aquaporin-4 (AQP4) in NMO patients suggested that NMO is a distinct entity, with a fundamentally different etiology from that of multiple sclerosis (MS)...
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| Vydané v: | Neurochemical research Ročník 38; číslo 5; s. 997 - 1001 |
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| Hlavní autori: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Springer US
01.05.2013
Springer Nature B.V |
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| ISSN: | 0364-3190, 1573-6903, 1573-6903 |
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| Abstract | Neuromyelitis optica (NMO) is an inflammatory disease that selectively affects the optic nerves and spinal cord. The discovery of NMO-IgG targeting aquaporin-4 (AQP4) in NMO patients suggested that NMO is a distinct entity, with a fundamentally different etiology from that of multiple sclerosis (MS). Although NMO usually leads to grave disability because of the more severe tissue destruction compared with classical MS, there have been several reports describing a benign form of NMO over a long disease term. NMO-IgG/AQP4 antibodies show high specificity but medium sensitivity for NMO, while the clinical relevance of AQP4 antibody titers remains to be determined. We aimed to clarify the clinical relevance of AQP4 antibody levels determined by a bridging enzyme-linked immunosorbent assay in 38 patients with NMO or NMO spectrum disorder. The AQP4 antibody levels were higher in patients with optic neuritis (ON) than in those without ON (
p
= 0.0164). Among the 12 patients examined in a longitudinal study, four showed an increase in the ELISA values during some relapses, and eight showed no clear correlation between the ELISA values and relapse. Of the four patients who demonstrated a steady rise in the antibody levels over time, two patients had no concomitant relapses, despite elevation of the AQP4 antibody levels. We conclude that high AQP4 antibody levels are associated with the occurrence of ON, but that the antibody levels themselves are not closely correlated with the onset of relapse. |
|---|---|
| AbstractList | Neuromyelitis optica (NMO) is an inflammatory disease that selectively affects the optic nerves and spinal cord. The discovery of NMO-IgG targeting aquaporin-4 (AQP4) in NMO patients suggested that NMO is a distinct entity, with a fundamentally different etiology from that of multiple sclerosis (MS). Although NMO usually leads to grave disability because of the more severe tissue destruction compared with classical MS, there have been several reports describing a benign form of NMO over a long disease term. NMO-IgG/AQP4 antibodies show high specificity but medium sensitivity for NMO, while the clinical relevance of AQP4 antibody titers remains to be determined. We aimed to clarify the clinical relevance of AQP4 antibody levels determined by a bridging enzyme-linked immunosorbent assay in 38 patients with NMO or NMO spectrum disorder. The AQP4 antibody levels were higher in patients with optic neuritis (ON) than in those without ON (
p
= 0.0164). Among the 12 patients examined in a longitudinal study, four showed an increase in the ELISA values during some relapses, and eight showed no clear correlation between the ELISA values and relapse. Of the four patients who demonstrated a steady rise in the antibody levels over time, two patients had no concomitant relapses, despite elevation of the AQP4 antibody levels. We conclude that high AQP4 antibody levels are associated with the occurrence of ON, but that the antibody levels themselves are not closely correlated with the onset of relapse. Neuromyelitis optica (NMO) is an inflammatory disease that selectively affects the optic nerves and spinal cord. The discovery of NMO-IgG targeting aquaporin-4 (AQP4) in NMO patients suggested that NMO is a distinct entity, with a fundamentally different etiology from that of multiple sclerosis (MS). Although NMO usually leads to grave disability because of the more severe tissue destruction compared with classical MS, there have been several reports describing a benign form of NMO over a long disease term. NMO-IgG/AQP4 antibodies show high specificity but medium sensitivity for NMO, while the clinical relevance of AQP4 antibody titers remains to be determined. We aimed to clarify the clinical relevance of AQP4 antibody levels determined by a bridging enzyme-linked immunosorbent assay in 38 patients with NMO or NMO spectrum disorder. The AQP4 antibody levels were higher in patients with optic neuritis (ON) than in those without ON (p = 0.0164). Among the 12 patients examined in a longitudinal study, four showed an increase in the ELISA values during some relapses, and eight showed no clear correlation between the ELISA values and relapse. Of the four patients who demonstrated a steady rise in the antibody levels over time, two patients had no concomitant relapses, despite elevation of the AQP4 antibody levels. We conclude that high AQP4 antibody levels are associated with the occurrence of ON, but that the antibody levels themselves are not closely correlated with the onset of relapse. Neuromyelitis optica (NMO) is an inflammatory disease that selectively affects the optic nerves and spinal cord. The discovery of NMO-IgG targeting aquaporin-4 (AQP4) in NMO patients suggested that NMO is a distinct entity, with a fundamentally different etiology from that of multiple sclerosis (MS). Although NMO usually leads to grave disability because of the more severe tissue destruction compared with classical MS, there have been several reports describing a benign form of NMO over a long disease term. NMO-IgG/AQP4 antibodies show high specificity but medium sensitivity for NMO, while the clinical relevance of AQP4 antibody titers remains to be determined. We aimed to clarify the clinical relevance of AQP4 antibody levels determined by a bridging enzyme-linked immunosorbent assay in 38 patients with NMO or NMO spectrum disorder. The AQP4 antibody levels were higher in patients with optic neuritis (ON) than in those without ON (p = 0.0164). Among the 12 patients examined in a longitudinal study, four showed an increase in the ELISA values during some relapses, and eight showed no clear correlation between the ELISA values and relapse. Of the four patients who demonstrated a steady rise in the antibody levels over time, two patients had no concomitant relapses, despite elevation of the AQP4 antibody levels. We conclude that high AQP4 antibody levels are associated with the occurrence of ON, but that the antibody levels themselves are not closely correlated with the onset of relapse.Neuromyelitis optica (NMO) is an inflammatory disease that selectively affects the optic nerves and spinal cord. The discovery of NMO-IgG targeting aquaporin-4 (AQP4) in NMO patients suggested that NMO is a distinct entity, with a fundamentally different etiology from that of multiple sclerosis (MS). Although NMO usually leads to grave disability because of the more severe tissue destruction compared with classical MS, there have been several reports describing a benign form of NMO over a long disease term. NMO-IgG/AQP4 antibodies show high specificity but medium sensitivity for NMO, while the clinical relevance of AQP4 antibody titers remains to be determined. We aimed to clarify the clinical relevance of AQP4 antibody levels determined by a bridging enzyme-linked immunosorbent assay in 38 patients with NMO or NMO spectrum disorder. The AQP4 antibody levels were higher in patients with optic neuritis (ON) than in those without ON (p = 0.0164). Among the 12 patients examined in a longitudinal study, four showed an increase in the ELISA values during some relapses, and eight showed no clear correlation between the ELISA values and relapse. Of the four patients who demonstrated a steady rise in the antibody levels over time, two patients had no concomitant relapses, despite elevation of the AQP4 antibody levels. We conclude that high AQP4 antibody levels are associated with the occurrence of ON, but that the antibody levels themselves are not closely correlated with the onset of relapse. Neuromyelitis optica (NMO) is an inflammatory disease that selectively affects the optic nerves and spinal cord. The discovery of NMO-IgG targeting aquaporin-4 (AQP4) in NMO patients suggested that NMO is a distinct entity, with a fundamentally different etiology from that of multiple sclerosis (MS). Although NMO usually leads to grave disability because of the more severe tissue destruction compared with classical MS, there have been several reports describing a benign form of NMO over a long disease term. NMO-IgG/AQP4 antibodies show high specificity but medium sensitivity for NMO, while the clinical relevance of AQP4 antibody titers remains to be determined. We aimed to clarify the clinical relevance of AQP4 antibody levels determined by a bridging enzyme-linked immunosorbent assay in 38 patients with NMO or NMO spectrum disorder. The AQP4 antibody levels were higher in patients with optic neuritis (ON) than in those without ON (p = 0.0164). Among the 12 patients examined in a longitudinal study, four showed an increase in the ELISA values during some relapses, and eight showed no clear correlation between the ELISA values and relapse. Of the four patients who demonstrated a steady rise in the antibody levels over time, two patients had no concomitant relapses, despite elevation of the AQP4 antibody levels. We conclude that high AQP4 antibody levels are associated with the occurrence of ON, but that the antibody levels themselves are not closely correlated with the onset of relapse.[PUBLICATION ABSTRACT] |
| Author | Furmaniak, Jadwiga Yoshimura, Satoshi Chen, Shu Yonekawa, Tomomi Smith, Bernard Rees Matsushita, Takuya Fichna, Jakub Kira, Jun-ichi Isobe, Noriko Masaki, Katsuhisa |
| Author_xml | – sequence: 1 givenname: Noriko surname: Isobe fullname: Isobe, Noriko organization: Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University – sequence: 2 givenname: Tomomi surname: Yonekawa fullname: Yonekawa, Tomomi organization: Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University – sequence: 3 givenname: Takuya surname: Matsushita fullname: Matsushita, Takuya organization: Department of Clinical Neuroimmunology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University – sequence: 4 givenname: Katsuhisa surname: Masaki fullname: Masaki, Katsuhisa organization: Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University – sequence: 5 givenname: Satoshi surname: Yoshimura fullname: Yoshimura, Satoshi organization: Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University – sequence: 6 givenname: Jakub surname: Fichna fullname: Fichna, Jakub organization: FIRS Laboratories, RSR Limited – sequence: 7 givenname: Shu surname: Chen fullname: Chen, Shu organization: FIRS Laboratories, RSR Limited – sequence: 8 givenname: Jadwiga surname: Furmaniak fullname: Furmaniak, Jadwiga organization: FIRS Laboratories, RSR Limited – sequence: 9 givenname: Bernard Rees surname: Smith fullname: Smith, Bernard Rees organization: FIRS Laboratories, RSR Limited – sequence: 10 givenname: Jun-ichi surname: Kira fullname: Kira, Jun-ichi email: kira@neuro.med.kyushu-u.ac.jp organization: Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23456674$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1007_s12026_018_9046_z crossref_primary_10_1016_j_brainresbull_2017_02_011 crossref_primary_10_3389_fneur_2021_746959 crossref_primary_10_3389_fneur_2022_866824 crossref_primary_10_1177_0883073814553974 crossref_primary_10_12688_f1000research_9476_1 crossref_primary_10_1016_j_bioelechem_2021_108041 crossref_primary_10_1111_cen3_12179 crossref_primary_10_1016_j_msard_2023_104718 crossref_primary_10_1159_000540496 crossref_primary_10_1016_j_msard_2022_104414 crossref_primary_10_1212_NXI_0000000000000121 |
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| Keywords | Relapse Neuromyelitis optica Aquaporin-4 antibody Optic neuritis Enzyme-linked immunosorbent assay |
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| SubjectTerms | Aquaporin 4 - immunology Autoantibodies - blood Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Enzyme-Linked Immunosorbent Assay Humans Neurochemistry Neurology Neuromyelitis Optica - blood Neurosciences Original Paper |
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| Title | Clinical Relevance of Serum Aquaporin-4 Antibody Levels in Neuromyelitis Optica |
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