Synthetic peptides derived from the variable regions of an anti-CD4 monoclonal antibody bind to CD4 and inhibit HIV-1 promoter activation in virus-infected cells

The monoclonal antibody (mAb) ST40, specific for the immunoglobulin complementarity-determining region (CDR) 3-like loop in domain 1 of the CD4 molecule, inhibits human immunodeficiency virus type 1 (HIV-1) promoter activity and viral transcription in HIV-infected cells. To design synthetic peptides...

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Bibliographic Details

Published in:	The Journal of biological chemistry Vol. 274; no. 6; p. 3789
Main Authors:	Monnet, C, Laune, D, Laroche-Traineau, J, Biard-Piechaczyk, M, Briant, L, Bès, C, Pugnière, M, Mani, J C, Pau, B, Cerutti, M, Devauchelle, G, Devaux, C, Granier, C, Chardès, T
Format:	Journal Article
Language:	English
Published:	United States 05.02.1999
Subjects:	Amino Acid Sequence Antibodies, Monoclonal - chemistry Base Sequence CD4 Antigens - immunology DNA Primers Gene Expression Regulation, Viral - immunology HeLa Cells HIV-1 - genetics Humans Immunoglobulin Variable Region - immunology Molecular Sequence Data Peptide Fragments - immunology Promoter Regions, Genetic
ISSN:	0021-9258
Online Access:	Get more information
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