Evidence that chronic hypoxia causes reversible impairment on male fertility

Aim： To evaluate the effect of chronic hypoxia on human spermatogenic parameters and their recovery time. Methods： Seminological parameters of six male healthy mountain trekkers were evaluated in normoxia at sea level. After 26 days exposure to altitude （ranging from 2 000 m to 5 600 m, Karakorum Ex...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Asian journal of andrology Ročník 10; číslo 4; s. 602 - 606
Hlavní autoři: Verratti, Vittore, Berardinelli, Francesco, Di Giulio, Camillo, Bosco, Gerardo, Cacchio, Marisa, Pellicciotta, Mario, Nicolai, Michele, Martinotti, Stefano, Tenaglia, Raffaele
Médium: Journal Article
Jazyk:angličtina
Vydáno: Oxford, UK Blackwell Publishing Ltd 01.07.2008
Medknow Publications & Media Pvt. Ltd
Témata:
Adaptation, Physiological - physiology
Adult
Aged
Altitude
high altitude
Humans
hypoxia
Hypoxia - complications
Infertility, Male - etiology
Infertility, Male - pathology
Infertility, Male - physiopathology
Male
male fertility
Middle Aged
Mountaineering
Oligospermia - etiology
Oligospermia - pathology
Oligospermia - physiopathology
seminological parameters
Sperm Count
Sperm Motility - physiology
Spermatogenesis - physiology
可逆损伤
生殖力
ISSN:1008-682X, 1745-7262
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Aim： To evaluate the effect of chronic hypoxia on human spermatogenic parameters and their recovery time. Methods： Seminological parameters of six male healthy mountain trekkers were evaluated in normoxia at sea level. After 26 days exposure to altitude （ranging from 2 000 m to 5 600 m, Karakorum Expedition） the same parameters were again evaluated after returning to sea level. These parameters were once again evaluated after 1 month and then again after 6 months. Results： Sperm count was found to be lower immediately after returning to sea level （P = 0.0004） and again after a month （P = 0.0008）. Normal levels were reached after 6 months. Spermatic motility （%） shows no reduction immediately after returning to sea level （P = 0.0583）, whereas after 1 month this reduction was significant （P = 0.0066）. After 6 months there was a recovery to pre-hypoxic exposure values. Abnormal or immature spermatozoa （%） increased immediately after returning to sea level （P = 0.0067） and then again after 1 month （P = 0.0004）. After 6 months there was a complete recovery to initial values. The total number of motile sperm in the ejaculate was found to be lower immediately after returning to sea level （P = 0.0024） and then again after 1 month （P = 0.0021）. After 6 months there was a recovery to pre-hypoxic exposure values. Conclusion： Chronic hypoxia induces a state of oligospermia and the normalization of such seminological parameters at the restoration of previous normoxic conditions after 6 months indicate the influence of oxygen supply in physiological mechanisms of spermatogenesis and male fertility.
Bibliografie:hypoxia
high altitude
R697
31-1795/R
seminological parameters
male fertility
male fertility; hypoxia; seminological parameters; high altitude
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1008-682X
1745-7262
DOI:10.1111/j.1745-7262.2008.00346.x