Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia

Background Three months ago, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) broke out in Wuhan, China, and spread rapidly around the world. Severe novel coronavirus pneumonia (NCP) patients have abnormal blood coagulation function, but their venous thromboembolism (VTE) prevalence is s...

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Veröffentlicht in:Journal of thrombosis and haemostasis Jg. 18; H. 6; S. 1421 - 1424
Hauptverfasser: Cui, Songping, Chen, Shuo, Li, Xiunan, Liu, Shi, Wang, Feng
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Limited 01.06.2020
John Wiley and Sons Inc
Schlagworte:
Adult
Aged
Betacoronavirus - pathogenicity
Biomarkers - blood
Blood Coagulation
Blood Coagulation Tests
Brief Report
China - epidemiology
coagulation parameter
Coronaviridae
Coronavirus Infections - blood
Coronavirus Infections - diagnosis
Coronavirus Infections - epidemiology
Coronavirus Infections - virology
Coronaviruses
COVID-19
D‐dimer
Female
Fibrin Fibrinogen Degradation Products - analysis
Health risk assessment
Humans
Incidence
Lymphocytes
Male
Middle Aged
novel coronavirus pneumonia
Pandemics
Pneumonia
Pneumonia, Viral - blood
Pneumonia, Viral - diagnosis
Pneumonia, Viral - epidemiology
Pneumonia, Viral - virology
Predictive Value of Tests
Prevalence
Prognosis
Reproducibility of Results
Retrospective Studies
Risk Assessment
Risk Factors
Risk groups
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Thromboembolism
Thromboplastin
THROMBOSIS
venous thromboembolism
Venous Thromboembolism - blood
Venous Thromboembolism - diagnosis
Venous Thromboembolism - epidemiology
Venous Thromboembolism - virology
China
D-dimer
novel coronavirus pneumonia
blood coagulation
coagulation parameter
venous thromboembolism
ISSN:1538-7933, 1538-7836, 1538-7836
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Zusammenfassung:Background Three months ago, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) broke out in Wuhan, China, and spread rapidly around the world. Severe novel coronavirus pneumonia (NCP) patients have abnormal blood coagulation function, but their venous thromboembolism (VTE) prevalence is still rarely mentioned. Objectives To determine the incidence of VTE in patients with severe NCP. Methods In this study, 81 severe NCP patients in the intensive care unit (ICU) of Union Hospital (Wuhan, China) were enrolled. The results of conventional coagulation parameters and lower limb vein ultrasonography of these patients were retrospectively collected and analyzed. Results The incidence of VTE in these patients was 25% (20/81), of which 8 patients with VTE events died. The VTE group was different from the non‐VTE group in age, lymphocyte counts, activated partial thromboplastin time (APTT), D‐dimer, etc. If 1.5 µg/mL was used as the D‐dimer cut‐off value to predicting VTE, the sensitivity was 85.0%, the specificity was 88.5%, and the negative predictive value (NPV) was 94.7%. Conclusions The incidence of VTE in patients with severe NCP is 25% (20/81), which may be related to poor prognosis. The significant increase of D‐dimer in severe NCP patients is a good index for identifying high‐risk groups of VTE.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Songping Cui and Shuo Chen contributed equally to this work.
Manuscript handled by: David Lillicrap
Final decision: David Lillicrap, 04 April 2020
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/jth.14830