Influenza virus hemagglutinin and neuraminidase, but not the matrix protein, are required for assembly and budding of plasmid-derived virus-like particles

For influenza virus, we developed an efficient, noncytotoxic, plasmid-based virus-like particle (VLP) system to reflect authentic virus particles. This system was characterized biochemically by analysis of VLP protein composition, morphologically by electron microscopy, and functionally with a VLP i...

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Bibliographic Details
Published in:	Journal of virology Vol. 81; no. 13; p. 7111
Main Authors:	Chen, Benjamin J, Leser, George P, Morita, Eiji, Lamb, Robert A
Format:	Journal Article
Language:	English
Published:	United States 01.07.2007
Subjects:	Animals Cercopithecus aethiops COS Cells DNA-Directed RNA Polymerases Gene Expression HeLa Cells Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - metabolism Humans Influenza A Virus, H3N2 Subtype - physiology Influenza A Virus, H3N2 Subtype - ultrastructure Models, Biological Neuraminidase - genetics Neuraminidase - metabolism Plasmids - genetics Plasmids - metabolism Vaccinia virus Vero Cells Viral Matrix Proteins - genetics Viral Matrix Proteins - metabolism Viral Proteins Virus Assembly - physiology
ISSN:	0022-538X
Online Access:	Get more information
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