Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

Cancer-related deregulation of miRNA biogenesis has been suggested, but the underlying mechanisms remain elusive. Here we report a previously unrecognized effect of hypoxia in the downregulation of Drosha and Dicer in cancer cells that leads to dysregulation of miRNA biogenesis and increased tumour...

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Bibliographic Details
Published in:	Nature communications Vol. 5; no. 1; p. 5202
Main Authors:	Rupaimoole, Rajesha, Wu, Sherry Y., Pradeep, Sunila, Ivan, Cristina, Pecot, Chad V., Gharpure, Kshipra M., Nagaraja, Archana S., Armaiz-Pena, Guillermo N., McGuire, Michael, Zand, Behrouz, Dalton, Heather J., Filant, Justyna, Miller, Justin Bottsford, Lu, Chunhua, Sadaoui, Nouara C., Mangala, Lingegowda S., Taylor, Morgan, van den Beucken, Twan, Koch, Elizabeth, Rodriguez-Aguayo, Cristian, Huang, Li, Bar-Eli, Menashe, Wouters, Bradly G., Radovich, Milan, Ivan, Mircea, Calin, George A., Zhang, Wei, Lopez-Berestein, Gabriel, Sood, Anil K.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 29.10.2014 Nature Publishing Group
Subjects:	13/106 13/109 13/31 13/89 14/1 14/5 14/63 38/15 38/22 38/39 59 631/337 631/67 64/60 82/51 Animals Biosynthesis Cancer Cell Hypoxia - genetics Cell Line, Tumor DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism Deregulation Disease Progression Down-Regulation - genetics Epithelial-Mesenchymal Transition - genetics Ets-1 protein Female Gene expression Gene Expression Regulation, Neoplastic Gene regulation Homeostasis Humanities and Social Sciences Humans Hypoxia Maturation Mice, Nude MicroRNAs MicroRNAs - biosynthesis MicroRNAs - genetics miRNA Models, Biological multidisciplinary Neoplasms - drug therapy Neoplasms - genetics Neoplasms - pathology Post-transcription Proto-Oncogene Protein c-ets-1 - genetics Proto-Oncogene Protein c-ets-1 - metabolism Ribonuclease III - genetics Ribonuclease III - metabolism Ribonucleic acid RNA Science siRNA Transcription factors Tumor microenvironment Tumors Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - metabolism
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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