Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression

Under steady-state conditions, bone marrow-derived immature myeloid cells (IMC) differentiate into granulocytes, macrophages and dendritic cells (DCs). This differentiation is impaired under chronic inflammatory conditions, which are typical for tumour progression, leading to the accumulation of IMC...

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Bibliographic Details
Published in:	British journal of cancer Vol. 120; no. 1; pp. 16 - 25
Main Authors:	Groth, Christopher, Hu, Xiaoying, Weber, Rebekka, Fleming, Viktor, Altevogt, Peter, Utikal, Jochen, Umansky, Viktor
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08.01.2019 Nature Publishing Group
Subjects:	631/250/251/1574 631/67/580/1884 Adenosine Animals Biomedical and Life Sciences Biomedicine Bone marrow Cancer Cancer immunotherapy Cancer Research Cell Differentiation - genetics Clinical trials Cytokines Dendritic cells Drug Resistance Epidemiology Humans Immune Tolerance Immunosuppression Immunosuppression - methods Immunotherapy Inflammation Leukocytes (granulocytic) Lymphocytes T Macrophages Macrophages - immunology Macrophages - pathology Metabolites Mice Molecular Medicine Myeloid cells Myeloid-Derived Suppressor Cells - immunology Neoplasms - immunology Neoplasms - therapy Oncology Review Review Article Suppressor cells T-Lymphocytes - immunology Tumor microenvironment Tumor Microenvironment - immunology Tumors
ISSN:	0007-0920, 1532-1827, 1532-1827
Online Access:	Get full text
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