Adenovirus 36 seropositivity is related to obesity risk, glycemic control, and leptin levels in Chilean subjects

Adenovirus 36 (Ad-36) has been associated to adiposity in animal and in vitro studies. Ad-36 seropositivity has also been reported to contribute to obesity risk in children and adult populations. We investigated the relationship of Ad-36 serology with obesity and metabolic parameters in a Chilean po...

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Published in:International Journal of Obesity Vol. 44; no. 1; pp. 159 - 166
Main Authors: Sapunar, Jorge, Fonseca, Luis, Molina, Víctor, Ortiz, Eugenia, Barra, Maria Ines, Reimer, Camila, Charles, Maria, Schneider, Constance, Ortiz, Manuel, Brito, Roberto, Manríquez, Víctor, Pavez, Monica, Cerda, Alvaro
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.01.2020
Subjects:
Adenoviridae - immunology
Adenoviridae Infections - complications
Adenoviridae Infections - epidemiology
Adenoviridae Infections - immunology
Adenovirus
Adenoviruses
Adiponectin
Adipose tissue
Adult
Anthropometry
Antibodies, Viral - blood
Antidiabetics
Blood glucose
Blood Glucose - analysis
Case-Control Studies
Chile
Cholesterol
Diabetes mellitus
Enzyme-linked immunosorbent assay
Female
Health risk assessment
Humans
Insulin
Laboratory tests
Leptin
Leptin - blood
Lipids
Lipoproteins (very low density)
Male
Middle Aged
Obesity
Obesity - complications
Obesity - epidemiology
Population
Population studies
Risk management
Seroepidemiologic Studies
Serology
Triglycerides
Chile
ISSN:0307-0565, 1476-5497, 1476-5497
Online Access:Get full text
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Summary:Adenovirus 36 (Ad-36) has been associated to adiposity in animal and in vitro studies. Ad-36 seropositivity has also been reported to contribute to obesity risk in children and adult populations. We investigated the relationship of Ad-36 serology with obesity and metabolic parameters in a Chilean population. Clinical and anthropometric data were obtained and blood samples were drawn from 99 lean (BMI: 18.5-24.9 kg/m ) and 151 obese (BMI > 30 kg/m ) subjects. Laboratory tests included lipid profile as well as glucose, insulin, leptin, and adiponectin levels. Ad-36 seropositivity was evaluated in serum samples by enzyme-linked immunosorbent assay. Seroprevalence of Ad-36 was higher in the obese group (58%) than in lean controls (34%) demonstrating that individuals previously infected with Ad-36 have higher risk of obesity in the study population (OR: 2.67, 95%CI: 1.58-4.51, p < 0.001). Interestingly, Ad-36 was related to lower concentrations of triglycerides and VLDL cholesterol in lean subjects (p = 0.049) and lower leptin in obese individuals (p = 0.014). Previous Ad-36 infection was also related to lower glycemia, insulinemia, and HOMA-IR (p < 0.05) in obese subjects who were not under antidiabetic drugs. Our results provide evidence of the contribution of previous Ad-36 infection to an increased risk of obesity in adult Chilean population. Ad-36 seropositivity was also associated to lipid profile, glycemic control, and leptin levels in adult Chilean population.
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ISSN:0307-0565
1476-5497
1476-5497
DOI:10.1038/s41366-019-0321-4