Morphine interaction with prasugrel: a double-blind, cross-over trial in healthy volunteers

Background Morphine decreases the concentrations and effects of clopidogrel, which could lead to treatment failure in myocardial infarction. Objectives To clarify whether more potent P2Y 12 -inhibitors may provide an effective alternative, we examined drug–drug interactions between morphine and pras...

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Bibliographic Details
Published in:	Clinical research in cardiology Vol. 105; no. 4; pp. 349 - 355
Main Authors:	Hobl, Eva-Luise, Reiter, Birgit, Schoergenhofer, Christian, Schwameis, Michael, Derhaschnig, Ulla, Lang, Irene Marthe, Stimpfl, Thomas, Jilma, Bernd
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2016 Springer Nature B.V
Subjects:	Adult Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Austria Biotransformation Cardiology Chromatography, Liquid Cross-Over Studies Double-Blind Method Drug Interactions Drug Monitoring - methods Female Healthy Volunteers Humans Male Medicine Medicine & Public Health Morphine - administration & dosage Morphine - adverse effects Original Paper Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - adverse effects Platelet Aggregation Inhibitors - blood Platelet Aggregation Inhibitors - pharmacokinetics Platelet Function Tests Prasugrel Hydrochloride - administration & dosage Prasugrel Hydrochloride - adverse effects Prasugrel Hydrochloride - blood Prasugrel Hydrochloride - pharmacokinetics Purinergic P2Y Receptor Antagonists - administration & dosage Purinergic P2Y Receptor Antagonists - adverse effects Purinergic P2Y Receptor Antagonists - blood Purinergic P2Y Receptor Antagonists - pharmacokinetics Risk Assessment Tandem Mass Spectrometry Young Adult Prasugrel Morphine Platelet function tests Drug interactions Vasodilator-stimulated phosphoprotein
ISSN:	1861-0684, 1861-0692, 1861-0692
Online Access:	Get full text
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