Early blood profiles of virus infection in a monkey model for Lassa fever

Acute arenavirus disease in primates, like Lassa hemorrhagic fever in humans, begins with flu-like symptoms and leads to death approximately 2 weeks after infection. Our goal was to identify molecular changes in blood that are related to disease progression. Rhesus macaques (Macaca mulatta) infected...

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Veröffentlicht in:Journal of virology Jg. 81; H. 15; S. 7960
Hauptverfasser: Djavani, Mahmoud M, Crasta, Oswald R, Zapata, Juan Carlos, Fei, Zhangjun, Folkerts, Otto, Sobral, Bruno, Swindells, Mark, Bryant, Joseph, Davis, Harry, Pauza, C David, Lukashevich, Igor S, Hammamieh, Rasha, Jett, Marti, Salvato, Maria S
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.08.2007
Schlagworte:
Animals
Chemokines - blood
Cytokines - blood
Disease Models, Animal
Disease Progression
Gene Expression Profiling
Gene Expression Regulation
Humans
Lassa Fever - blood
Lassa virus - metabolism
Lymphocytic choriomeningitis virus - genetics
Lymphocytic choriomeningitis virus - metabolism
Macaca mulatta - blood
Macaca mulatta - virology
Molecular Sequence Data
Monkey Diseases - blood
Monkey Diseases - virology
Oligonucleotide Array Sequence Analysis
Viremia
ISSN:0022-538X
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Zusammenfassung:Acute arenavirus disease in primates, like Lassa hemorrhagic fever in humans, begins with flu-like symptoms and leads to death approximately 2 weeks after infection. Our goal was to identify molecular changes in blood that are related to disease progression. Rhesus macaques (Macaca mulatta) infected intravenously with a lethal dose of lymphocytic choriomeningitis virus (LCMV) provide a model for Lassa virus infection of humans. Blood samples taken before and during the course of infection were used to monitor gene expression changes that paralleled disease onset. Changes in blood showed major disruptions in eicosanoid, immune response, and hormone response pathways. Approximately 12% of host genes alter their expression after LCMV infection, and a subset of these genes can discriminate between virulent and non-virulent LCMV infection. Major transcription changes have been given preliminary confirmation by quantitative PCR and protein studies and will be valuable candidates for future validation as biomarkers for arenavirus disease.
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SourceType-Scholarly Journals-1
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ISSN:0022-538X
DOI:10.1128/JVI.00536-07