Bioprospecting Trichoderma: A Systematic Roadmap to Screen Genomes and Natural Products for Biocontrol Applications

Natural products derived from microbes are crucial innovations that would help in reaching sustainability development goals worldwide while achieving bioeconomic growth. Trichoderma species are well-studied model fungal organisms used for their biocontrol properties with great potential to alleviate...

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Vydané v:Frontiers in fungal biology Ročník 2; číslo 9; s. 716511
Hlavní autori: Rush, Tomás A., Shrestha, Him K., Gopalakrishnan Meena, Muralikrishnan, Spangler, Margaret K., Ellis, J. Christopher, Labbé, Jesse L., Abraham, Paul E.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Frontiers Media S.A 16.09.2021
Predmet:
antimicrobials
BASIC BIOLOGICAL SCIENCES
functional genomics
Fungal Biology
integrated pest management
plant-microbe interactions
predictive biology
secondary metabolites
ISSN:2673-6128, 2673-6128
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Shrnutí:Natural products derived from microbes are crucial innovations that would help in reaching sustainability development goals worldwide while achieving bioeconomic growth. Trichoderma species are well-studied model fungal organisms used for their biocontrol properties with great potential to alleviate the use of agrochemicals in agriculture. However, identifying and characterizing effective natural products in novel species or strains as biological control products remains a meticulous process with many known challenges to be navigated. Integration of recent advancements in various “omics” technologies, next generation biodesign, machine learning, and artificial intelligence approaches could greatly advance bioprospecting goals. Herein, we propose a roadmap for assessing the potential impact of already known or newly discovered Trichoderma species for biocontrol applications. By screening publicly available Trichoderma genome sequences, we first highlight the prevalence of putative biosynthetic gene clusters and antimicrobial peptides among genomes as an initial step toward predicting which organisms could increase the diversity of natural products. Next, we discuss high-throughput methods for screening organisms to discover and characterize natural products and how these findings impact both fundamental and applied research fields.
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USDOE
USDOE Office of Science (SC), Biological and Environmental Research (BER)
AC05-00OR22725
This article was submitted to Fungi-Plant Interactions, a section of the journal Frontiers in Fungal Biology
Edited by: Artemio Mendoza-Mendoza, Lincoln University, New Zealand
Reviewed by: Birinchi Kumar Sarma, Banaras Hindu University, India; Rosa Hermosa, University of Salamanca, Spain
ISSN:2673-6128
2673-6128
DOI:10.3389/ffunb.2021.716511