A mouse model that is immunologically tolerant to reporter and modifier proteins

Reporter proteins have become an indispensable tool in biomedical research. However, exogenous introduction of these reporters into mice poses a risk of rejection by the immune system. Here, we describe the generation, validation and application of a multiple reporter protein tolerant ‘Tol' mou...

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Bibliographic Details
Published in:	Communications biology Vol. 3; no. 1; p. 273
Main Authors:	Bresser, Kaspar, Dijkgraaf, Feline E., Pritchard, Colin E. J., Huijbers, Ivo J., Song, Ji-Ying, Rohr, Jan C., Scheeren, Ferenc A., Schumacher, Ton N.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 29.05.2020 Nature Publishing Group
Subjects:	38/35 38/44 631/250/1619/554/1834 631/250/2152/569 631/61/17/1511 64/110 64/60 Biology Biomedical and Life Sciences CD8 antigen Clonal deletion Epitopes Gene transfer Immune system Life Sciences Lymphocytes T Proteins Rodents
ISSN:	2399-3642, 2399-3642
Online Access:	Get full text
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