Altered Regional Brain Glucose Metabolism in Diffuse Large B-Cell Lymphoma Patients Treated With Cyclophosphamide, Epirubicin, Vincristine, and Prednisone: An Fluorodeoxyglucose Positron Emission Tomography Study of 205 Cases
Background: A growing number of neuroimaging studies reported that chemotherapy might impair brain functions, leading to persistent cognitive alterations in a subset of cancer patients. The present study aimed to investigate the regional brain glucose metabolism differences between diffuse large B c...
Uložené v:
| Vydané v: | Frontiers in neuroscience Ročník 16; s. 914556 |
|---|---|
| Hlavní autori: | , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
Lausanne
Frontiers Research Foundation
15.06.2022
Frontiers Media S.A |
| Predmet: | |
| ISSN: | 1662-453X, 1662-4548, 1662-453X |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Background: A growing number of neuroimaging studies reported that chemotherapy might impair brain functions, leading to persistent cognitive alterations in a subset of cancer patients. The present study aimed to investigate the regional brain glucose metabolism differences between diffuse large B cell lymphoma (DLBCL) patients treated with cyclophosphamide, epirubicin, vincristine, and prednisone and controls sing positron emission tomography with 18F-labeled fluoro-2-deoxyglucose integrated with computed tomography (18F-FDG PET/CT) scanning. Methods: We analyzed 18F-FDG PET data from 205 right-handed subjects (for avoiding the influence of handedness factors on brain function), including 105 post-chemotherapy DLBCL patients and 100 controls. The two groups had similar average age, gender ratio, and years of education. First, we compared the regional brain glucose metabolism using a voxel-based two-sample t-test. Second, we compared the interregional correlation. Finally, we investigated the correlations between the regional brain glucose metabolism and the number of chemotherapy cycles. Results: Compared with the controls, the post-chemotherapy group showed higher metabolism in the right hippocampus and parahippocampal gyrus (region of interest (ROI) 1) and the left hippocampus (ROI 2), and lower metabolism in the left medial orbitofrontal gyrus (ROI 3), the left medial superior frontal gyrus (ROI 4), and the left superior frontal gyrus (ROI 5). The two groups had different interregional correlations between ROI 3 and ROI 5. In some brain regions— mainly located in the bilateral frontal gyrus—the number of chemotherapy cycles was positively correlated with the regional brain glucose metabolism. Meanwhile, in some bilateral hippocampus regions, these two parameters were negatively correlated. Conclusion: The present study provides solid data on the regional brain glucose metabolism differences between post-chemotherapy DLBCL patients and controls. These results should improve our understanding of human brain functions alterations in post-chemotherapy DLBCL patients and suggest that 18F-FDG PET/CT scanning is a valuable neuroimaging technology for studying chemotherapy-induced brain function changes. |
|---|---|
| AbstractList | A growing number of neuroimaging studies reported that chemotherapy might impair brain functions, leading to persistent cognitive alterations in a subset of cancer patients. The present study aimed to investigate the regional brain glucose metabolism differences between diffuse large B cell lymphoma (DLBCL) patients treated with cyclophosphamide, epirubicin, vincristine, and prednisone and controls using positron emission tomography with 18F-labeled fluoro-2-deoxyglucose integrated with computed tomography (18F-FDG PET/CT) scanning.BackgroundA growing number of neuroimaging studies reported that chemotherapy might impair brain functions, leading to persistent cognitive alterations in a subset of cancer patients. The present study aimed to investigate the regional brain glucose metabolism differences between diffuse large B cell lymphoma (DLBCL) patients treated with cyclophosphamide, epirubicin, vincristine, and prednisone and controls using positron emission tomography with 18F-labeled fluoro-2-deoxyglucose integrated with computed tomography (18F-FDG PET/CT) scanning.We analyzed 18F-FDG PET data from 205 right-handed subjects (for avoiding the influence of handedness factors on brain function), including 105 post-chemotherapy DLBCL patients and 100 controls. The two groups had similar average age, gender ratio, and years of education. First, we compared the regional brain glucose metabolism using a voxel-based two-sample t-test. Second, we compared the interregional correlation. Finally, we investigated the correlations between the regional brain glucose metabolism and the number of chemotherapy cycles.MethodsWe analyzed 18F-FDG PET data from 205 right-handed subjects (for avoiding the influence of handedness factors on brain function), including 105 post-chemotherapy DLBCL patients and 100 controls. The two groups had similar average age, gender ratio, and years of education. First, we compared the regional brain glucose metabolism using a voxel-based two-sample t-test. Second, we compared the interregional correlation. Finally, we investigated the correlations between the regional brain glucose metabolism and the number of chemotherapy cycles.Compared with the controls, the post-chemotherapy group showed higher metabolism in the right hippocampus and parahippocampal gyrus (region of interest (ROI) 1) and the left hippocampus (ROI 2), and lower metabolism in the left medial orbitofrontal gyrus (ROI 3), the left medial superior frontal gyrus (ROI 4), and the left superior frontal gyrus (ROI 5). The two groups had different interregional correlations between ROI 3 and ROI 5. In some brain regions-mainly located in the bilateral frontal gyrus-the number of chemotherapy cycles was positively correlated with the regional brain glucose metabolism. Meanwhile, in some bilateral hippocampus regions, these two parameters were negatively correlated.ResultsCompared with the controls, the post-chemotherapy group showed higher metabolism in the right hippocampus and parahippocampal gyrus (region of interest (ROI) 1) and the left hippocampus (ROI 2), and lower metabolism in the left medial orbitofrontal gyrus (ROI 3), the left medial superior frontal gyrus (ROI 4), and the left superior frontal gyrus (ROI 5). The two groups had different interregional correlations between ROI 3 and ROI 5. In some brain regions-mainly located in the bilateral frontal gyrus-the number of chemotherapy cycles was positively correlated with the regional brain glucose metabolism. Meanwhile, in some bilateral hippocampus regions, these two parameters were negatively correlated.The present study provides solid data on the regional brain glucose metabolism differences between post-chemotherapy DLBCL patients and controls. These results should improve our understanding of human brain functions alterations in post-chemotherapy DLBCL patients and suggest that 18F-FDG PET/CT scanning is a valuable neuroimaging technology for studying chemotherapy-induced brain function changes.ConclusionThe present study provides solid data on the regional brain glucose metabolism differences between post-chemotherapy DLBCL patients and controls. These results should improve our understanding of human brain functions alterations in post-chemotherapy DLBCL patients and suggest that 18F-FDG PET/CT scanning is a valuable neuroimaging technology for studying chemotherapy-induced brain function changes. Background: A growing number of neuroimaging studies reported that chemotherapy might impair brain functions, leading to persistent cognitive alterations in a subset of cancer patients. The present study aimed to investigate the regional brain glucose metabolism differences between diffuse large B cell lymphoma (DLBCL) patients treated with cyclophosphamide, epirubicin, vincristine, and prednisone and controls sing positron emission tomography with 18F-labeled fluoro-2-deoxyglucose integrated with computed tomography (18F-FDG PET/CT) scanning. Methods: We analyzed 18F-FDG PET data from 205 right-handed subjects (for avoiding the influence of handedness factors on brain function), including 105 post-chemotherapy DLBCL patients and 100 controls. The two groups had similar average age, gender ratio, and years of education. First, we compared the regional brain glucose metabolism using a voxel-based two-sample t-test. Second, we compared the interregional correlation. Finally, we investigated the correlations between the regional brain glucose metabolism and the number of chemotherapy cycles. Results: Compared with the controls, the post-chemotherapy group showed higher metabolism in the right hippocampus and parahippocampal gyrus (region of interest (ROI) 1) and the left hippocampus (ROI 2), and lower metabolism in the left medial orbitofrontal gyrus (ROI 3), the left medial superior frontal gyrus (ROI 4), and the left superior frontal gyrus (ROI 5). The two groups had different interregional correlations between ROI 3 and ROI 5. In some brain regions— mainly located in the bilateral frontal gyrus—the number of chemotherapy cycles was positively correlated with the regional brain glucose metabolism. Meanwhile, in some bilateral hippocampus regions, these two parameters were negatively correlated. Conclusion: The present study provides solid data on the regional brain glucose metabolism differences between post-chemotherapy DLBCL patients and controls. These results should improve our understanding of human brain functions alterations in post-chemotherapy DLBCL patients and suggest that 18F-FDG PET/CT scanning is a valuable neuroimaging technology for studying chemotherapy-induced brain function changes. BackgroundA growing number of neuroimaging studies reported that chemotherapy might impair brain functions, leading to persistent cognitive alterations in a subset of cancer patients. The present study aimed to investigate the regional brain glucose metabolism differences between diffuse large B cell lymphoma (DLBCL) patients treated with cyclophosphamide, epirubicin, vincristine, and prednisone and controls using positron emission tomography with 18F-labeled fluoro-2-deoxyglucose integrated with computed tomography (18F-FDG PET/CT) scanning.MethodsWe analyzed 18F-FDG PET data from 205 right-handed subjects (for avoiding the influence of handedness factors on brain function), including 105 post-chemotherapy DLBCL patients and 100 controls. The two groups had similar average age, gender ratio, and years of education. First, we compared the regional brain glucose metabolism using a voxel-based two-sample t-test. Second, we compared the interregional correlation. Finally, we investigated the correlations between the regional brain glucose metabolism and the number of chemotherapy cycles.ResultsCompared with the controls, the post-chemotherapy group showed higher metabolism in the right hippocampus and parahippocampal gyrus (region of interest (ROI) 1) and the left hippocampus (ROI 2), and lower metabolism in the left medial orbitofrontal gyrus (ROI 3), the left medial superior frontal gyrus (ROI 4), and the left superior frontal gyrus (ROI 5). The two groups had different interregional correlations between ROI 3 and ROI 5. In some brain regions—mainly located in the bilateral frontal gyrus—the number of chemotherapy cycles was positively correlated with the regional brain glucose metabolism. Meanwhile, in some bilateral hippocampus regions, these two parameters were negatively correlated.ConclusionThe present study provides solid data on the regional brain glucose metabolism differences between post-chemotherapy DLBCL patients and controls. These results should improve our understanding of human brain functions alterations in post-chemotherapy DLBCL patients and suggest that 18F-FDG PET/CT scanning is a valuable neuroimaging technology for studying chemotherapy-induced brain function changes. |
| Author | Zhang, Qin Cui, Can Hu, Yuxiao Zhang, Yun |
| AuthorAffiliation | 2 Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University , Nanjing , China 1 Department of PET/CT Center, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University , Nanjing , China |
| AuthorAffiliation_xml | – name: 1 Department of PET/CT Center, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University , Nanjing , China – name: 2 Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University , Nanjing , China |
| Author_xml | – sequence: 1 givenname: Yuxiao surname: Hu fullname: Hu, Yuxiao – sequence: 2 givenname: Qin surname: Zhang fullname: Zhang, Qin – sequence: 3 givenname: Can surname: Cui fullname: Cui, Can – sequence: 4 givenname: Yun surname: Zhang fullname: Zhang, Yun |
| BookMark | eNp9UsuOEzEQHKFF7AM-gJslLhw2wWOP58EBKRuyy0pBRBAeN6vH40kceexZ24OYz-VPcDYRYvfAya2u6lK5u86TE2ONTJKXKZ5SWlZvWqOMnxJMyLRKM8byJ8lZmudkkjH64-Sf-jQ5936HcU7KjDxLTikryqxk2Vnye6aDdLJBn-VGWQMaXTlQBt3oQVgv0UcZoLZa-Q7F7nvVtkPsLsFtJLqazKXWaDl2_dZ2gFYQlDTBo7WTEKLmdxW2aD4KbSPB91voVCMv0aJXbqiVUOYSfVNGOOWDMhEA06BVNGOUjx99i2YGXevBOttI-2vcHC2trFfBWYMWnfI-mkZr29mNg347oi9haEZkW0QwQ3Pw0j9PnragvXxxfC-Sr9eL9fzDZPnp5nY-W05EVuAwgZYBZJhVbZlDwQhjNakIKUlBAbc5tHWK6zZnLY5ljasC14zQiEhRpClt6EVye9BtLOx471QHbuQWFL9vWLfh4IISWvJCAuTxGk0NOKtYVQtcN4IUkqaCFdle691Bqx_qTjYibtWBfiD6EDFqyzf2J69IhmmZRYHXRwFn7wbpA4-7EvFaYKQdPCd5yTBNywpH6qtH1J0dXEzCnlXkeYVTQiMrPbCEs9472f41k2K-DyO_DyPfh5EfwhhnikczQoWYEbv3rPR_Jv8AB1jrTg |
| CitedBy_id | crossref_primary_10_3390_cancers17132222 crossref_primary_10_1186_s13550_023_01046_6 |
| Cites_doi | 10.3389/fneur.2022.777808 10.1371/journal.pone.0083821 10.1371/journal.pone.0156016 10.1016/j.ccell.2021.10.006 10.3389/fnhum.2012.00200 10.1007/s10549-006-9380-z 10.1016/j.ejca.2021.11.006 10.3892/ol.2014.2765 10.1007/s00259-021-05233-2 10.1200/JCO.2011.38.5674 10.1097/RLU.0b013e318292aa81 10.1007/s11065-020-09441-9 10.1002/ana.20185 10.1177/0284185114529106 10.3390/cancers13235900 10.1016/s2214-109x(21)00181-9 10.1002/gps.4189 10.3390/jcm8020234 10.1038/s41598-021-98004-w 10.1016/j.critrevonc.2016.07.003 10.3390/ijms20194669 10.3389/fnins.2022.806876 10.3322/caac.21258 10.1158/0008-5472.CAN-14-2237 10.1016/j.neuroscience.2017.10.048 10.2147/IJGM.S34093 10.1007/s11682-012-9213-0 10.3389/fonc.2021.673340 10.1093/annonc/mdz410 10.1007/s11682-013-9256-x 10.1007/s10549-012-2385-x 10.1007/s12149-019-01363-8 10.3389/fonc.2020.00147 10.1007/s00259-014-2961-x 10.1007/s00330-016-4531-z 10.1200/Jco.19.01866 10.1007/s10549-011-1888-1 |
| ContentType | Journal Article |
| Copyright | 2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2022 Hu, Zhang, Cui and Zhang. Copyright © 2022 Hu, Zhang, Cui and Zhang. 2022 Hu, Zhang, Cui and Zhang |
| Copyright_xml | – notice: 2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright © 2022 Hu, Zhang, Cui and Zhang. – notice: Copyright © 2022 Hu, Zhang, Cui and Zhang. 2022 Hu, Zhang, Cui and Zhang |
| DBID | AAYXX CITATION 3V. 7XB 88I 8FE 8FH 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO GNUQQ HCIFZ LK8 M2P M7P PHGZM PHGZT PIMPY PKEHL PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 5PM DOA |
| DOI | 10.3389/fnins.2022.914556 |
| DatabaseName | CrossRef ProQuest Central (Corporate) ProQuest Central (purchase pre-March 2016) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central ProQuest Central Student SciTech Collection (ProQuest) Biological Sciences Science Database (ProQuest) Biological Science Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Central (New) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition Biological Science Database ProQuest SciTech Collection ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Education |
| EISSN | 1662-453X |
| ExternalDocumentID | oai_doaj_org_article_7eaa6006dba04959bc0bdc27e31c574d PMC9240384 10_3389_fnins_2022_914556 |
| GroupedDBID | --- 29H 2WC 53G 5GY 5VS 8FE 8FH 9T4 AAFWJ AAYXX ABUWG ACGFO ACGFS ADRAZ AEGXH AENEX AFKRA AFPKN AIAGR ALMA_UNASSIGNED_HOLDINGS AZQEC BBNVY BENPR BHPHI BPHCQ CITATION CS3 DIK DU5 E3Z EBS EJD EMOBN F5P FRP GROUPED_DOAJ GX1 HCIFZ HYE KQ8 LK8 M2P M48 M7P O5R O5S OK1 OVT P2P PGMZT PIMPY PQQKQ PROAC RNS RPM W2D 3V. 7XB 88I 8FK ACXDI CCPQU DWQXO GNUQQ PHGZM PHGZT PKEHL PQEST PQGLB PQUKI PRINS Q9U 7X8 5PM |
| ID | FETCH-LOGICAL-c470t-af5aa4059f86a75255b29228273a0f6afb10bf65f0afbb0970b5230f6ec7113d3 |
| IEDL.DBID | M2P |
| ISICitedReferencesCount | 3 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000817983900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1662-453X 1662-4548 |
| IngestDate | Fri Oct 03 12:46:20 EDT 2025 Thu Aug 21 14:11:14 EDT 2025 Fri Sep 05 08:20:42 EDT 2025 Mon Jun 30 09:39:57 EDT 2025 Sat Nov 29 02:55:18 EST 2025 Tue Nov 18 22:26:20 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c470t-af5aa4059f86a75255b29228273a0f6afb10bf65f0afbb0970b5230f6ec7113d3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Reviewed by: Agata Pietrzak, Poznań University of Medical Sciences, Poland; Jules Zhang-Yin, Clinique Sud Luxembourg, Vivalia, Belgium This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience Edited by: Giorgio Biasiotto, University of Brescia, Italy |
| OpenAccessLink | https://www.proquest.com/docview/2676690123?pq-origsite=%requestingapplication% |
| PMID | 35784854 |
| PQID | 2676690123 |
| PQPubID | 4424402 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_7eaa6006dba04959bc0bdc27e31c574d pubmedcentral_primary_oai_pubmedcentral_nih_gov_9240384 proquest_miscellaneous_2685031890 proquest_journals_2676690123 crossref_primary_10_3389_fnins_2022_914556 crossref_citationtrail_10_3389_fnins_2022_914556 |
| PublicationCentury | 2000 |
| PublicationDate | 2022-06-15 |
| PublicationDateYYYYMMDD | 2022-06-15 |
| PublicationDate_xml | – month: 06 year: 2022 text: 2022-06-15 day: 15 |
| PublicationDecade | 2020 |
| PublicationPlace | Lausanne |
| PublicationPlace_xml | – name: Lausanne |
| PublicationTitle | Frontiers in neuroscience |
| PublicationYear | 2022 |
| Publisher | Frontiers Research Foundation Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Research Foundation – name: Frontiers Media S.A |
| References | Boellaard (B4) 2015; 42 Sorokin (B30) 2014; 39 Adams (B2) 2016; 106 Baudino (B3) 2012; 56 Frood (B10) 2021; 48 Lange (B17) 2019; 30 Lee (B18) 2019; 8 Sousa (B31) 2020; 30 Tan (B32) 2022; 16 Winocur (B38) 2018; 369 Kimani (B15) 2021; 9 McDonald (B21) 2012; 30 Wilson (B37) 2021; 39 Schwarzkopf (B28) 2012; 6 Juan (B13) 2022; 161 Lopez Zunini (B20) 2013; 7 McDonald (B22) 2013; 7 Liu (B19) 2016; 11 Conroy (B8) 2013; 137 Du (B9) 2021; 11 Wefel (B36) 2015; 65 Chiaravalloti (B7) 2015; 9 Hu (B11) 2013; 8 Tauty (B33) 2019; 33 Zhang (B39) 2017; 27 Koppelmans (B16) 2012; 132 Ponto (B26) 2015; 30 Niida (B23) 2012; 5 Kiesl (B14) 2022; 13 Acharya (B1) 2015; 75 Rzeski (B27) 2004; 56 Silverman (B29) 2007; 103 Bouroumeau (B5) 2021; 13 Chen (B6) 2019; 9 Pietrzak (B25) 2021; 11 Hu (B12) 2015; 56 Treglia (B34) 2019; 20 Wagner (B35) 2020; 38 Peukert (B24) 2020; 10 |
| References_xml | – volume: 13 year: 2022 ident: B14 article-title: Protocol for the Exercise, Cancer and Cognition - The ECCO-Study: A Randomized Controlled Trial of Simultaneous Exercise During Neo-/Adjuvant Chemotherapy in Breast Cancer Patients and Its Effects on Neurocognition. publication-title: Front. Neurol. doi: 10.3389/fneur.2022.777808 – volume: 8 year: 2013 ident: B11 article-title: Gender differences of brain glucose metabolic networks revealed by FDG-PET: evidence from a large cohort of 400 young adults. publication-title: PLoS One doi: 10.1371/journal.pone.0083821 – volume: 11 year: 2016 ident: B19 article-title: Perfusion Deficits and Functional Connectivity Alterations in Memory-Related Regions of Patients with Post-Traumatic Stress Disorder. publication-title: PLoS One doi: 10.1371/journal.pone.0156016 – volume: 39 start-page: 1643 year: 2021 ident: B37 article-title: Effect of ibrutinib with R-CHOP chemotherapy in genetic subtypes of DLBCL. publication-title: Cancer Cell doi: 10.1016/j.ccell.2021.10.006 – volume: 6 year: 2012 ident: B28 article-title: Better ways to improve standards in brain-behavior correlation analysis. publication-title: Front. Hum. Neurosci. doi: 10.3389/fnhum.2012.00200 – volume: 103 start-page: 303 year: 2007 ident: B29 article-title: Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5-10 years after chemotherapy. publication-title: Breast Cancer Res. Treat. doi: 10.1007/s10549-006-9380-z – volume: 161 start-page: 10 year: 2022 ident: B13 article-title: Probiotic supplement attenuates chemotherapy-related cognitive impairment in patients with breast cancer: a randomised, double-blind, and placebo-controlled trial. publication-title: Eur. J. Cancer doi: 10.1016/j.ejca.2021.11.006 – volume: 9 start-page: 685 year: 2015 ident: B7 article-title: Brain metabolic changes in Hodgkin disease patients following diagnosis and during the disease course: an (18)F-FDG PET/CT study. publication-title: Oncol. Lett. doi: 10.3892/ol.2014.2765 – volume: 48 start-page: 3198 year: 2021 ident: B10 article-title: Baseline PET/CT imaging parameters for prediction of treatment outcome in Hodgkin and diffuse large B cell lymphoma: a systematic review. publication-title: Eur. J. Nucl. Med. Mol. Imaging doi: 10.1007/s00259-021-05233-2 – volume: 30 start-page: 2500 year: 2012 ident: B21 article-title: Alterations in brain activation during working memory processing associated with breast cancer and treatment: a prospective functional magnetic resonance imaging study. publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2011.38.5674 – volume: 39 start-page: e35 year: 2014 ident: B30 article-title: Adverse functional effects of chemotherapy on whole-brain metabolism: a PET/CT quantitative analysis of FDG metabolic pattern of the “chemo-brain”. publication-title: Clin. Nucl. Med. doi: 10.1097/RLU.0b013e318292aa81 – volume: 30 start-page: 287 year: 2020 ident: B31 article-title: The Developmental Trajectory of Cancer-Related Cognitive Impairment in Breast Cancer Patients: A Systematic Review of Longitudinal Neuroimaging Studies. publication-title: Neuropsychol. Rev. doi: 10.1007/s11065-020-09441-9 – volume: 56 start-page: 351 year: 2004 ident: B27 article-title: Anticancer agents are potent neurotoxins in vitro and in vivo. publication-title: Ann. Neurol. doi: 10.1002/ana.20185 – volume: 56 start-page: 204 year: 2015 ident: B12 article-title: Small-worldness and gender differences of large scale brain metabolic covariance networks in young adults: a FDG PET study of 400 subjects. publication-title: Acta Radiol. doi: 10.1177/0284185114529106 – volume: 13 year: 2021 ident: B5 article-title: CYCLON and NPM1 Cooperate within an Oncogenic Network Predictive of R-CHOP Response in DLBCL. publication-title: Cancers doi: 10.3390/cancers13235900 – volume: 9 start-page: e1008 year: 2021 ident: B15 article-title: Safety and efficacy of rituximab in patients with diffuse large B-cell lymphoma in Malawi: a prospective, single-arm, non-randomised phase 1/2 clinical trial. publication-title: Lancet Glob. Health doi: 10.1016/s2214-109x(21)00181-9 – volume: 30 start-page: 587 year: 2015 ident: B26 article-title: Frontal hypometabolism in elderly breast cancer survivors determined by [(18)F]fluorodeoxyglucose (FDG) positron emission tomography (PET): a pilot study. publication-title: Int. J. Geriatr. Psychiatry doi: 10.1002/gps.4189 – volume: 8 year: 2019 ident: B18 article-title: Trastuzumab Induced Chemobrain, Atorvastatin Rescued Chemobrain with Enhanced Anticancer Effect and without Hair Loss-Side Effect. publication-title: J. Clin. Med. doi: 10.3390/jcm8020234 – volume: 11 year: 2021 ident: B25 article-title: Detection of clinically silent brain lesions in [18F]FDG PET/CT study in oncological patients: analysis of over 10,000 studies. publication-title: Sci. Rep. doi: 10.1038/s41598-021-98004-w – volume: 106 start-page: 55 year: 2016 ident: B2 article-title: Prognostic value of interim FDG-PET in R-CHOP-treated diffuse large B-cell lymphoma: systematic review and meta-analysis. publication-title: Crit. Rev. Oncol. Hematol. doi: 10.1016/j.critrevonc.2016.07.003 – volume: 20 year: 2019 ident: B34 article-title: Diagnostic Performance and Prognostic Value of PET/CT with Different Tracers for Brain Tumors: A Systematic Review of Published Meta-Analyses. publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20194669 – volume: 16 year: 2022 ident: B32 article-title: Positron Emission Tomography in the Neuroimaging of Autism Spectrum Disorder: A Review. publication-title: Front. Neurosci. doi: 10.3389/fnins.2022.806876 – volume: 65 start-page: 123 year: 2015 ident: B36 article-title: Clinical characteristics, pathophysiology, and management of noncentral nervous system cancer-related cognitive impairment in adults. publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21258 – volume: 75 start-page: 676 year: 2015 ident: B1 article-title: Stem cell transplantation reverses chemotherapy-induced cognitive dysfunction. publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-14-2237 – volume: 369 start-page: 51 year: 2018 ident: B38 article-title: Neurobiological Mechanisms of Chemotherapy-induced Cognitive Impairment in a Transgenic Model of Breast Cancer. publication-title: Neuroscience doi: 10.1016/j.neuroscience.2017.10.048 – volume: 5 start-page: 667 year: 2012 ident: B23 article-title: Identification of atrophy of the subgenual anterior cingulate cortex, in particular the subcallosal area, as an effective auxiliary means of diagnosis for major depressive disorder. publication-title: Int. J. Gen. Med. doi: 10.2147/IJGM.S34093 – volume: 7 start-page: 460 year: 2013 ident: B20 article-title: Differences in verbal memory retrieval in breast cancer chemotherapy patients compared to healthy controls: a prospective fMRI study. publication-title: Brain Imaging Behav. doi: 10.1007/s11682-012-9213-0 – volume: 11 year: 2021 ident: B9 article-title: Doxorubicin-Induced Cognitive Impairment: The Mechanistic Insights. publication-title: Front. Oncol. doi: 10.3389/fonc.2021.673340 – volume: 30 start-page: 1925 year: 2019 ident: B17 article-title: Cancer-related cognitive impairment: an update on state of the art, detection, and management strategies in cancer survivors. publication-title: Ann. Oncol. doi: 10.1093/annonc/mdz410 – volume: 7 start-page: 374 year: 2013 ident: B22 article-title: Alterations in brain structure related to breast cancer and its treatment: chemotherapy and other considerations. publication-title: Brain Imaging Behav. doi: 10.1007/s11682-013-9256-x – volume: 137 start-page: 493 year: 2013 ident: B8 article-title: Alterations in brain structure and function in breast cancer survivors: effect of post-chemotherapy interval and relation to oxidative DNA damage. publication-title: Breast Cancer Res. Treat. doi: 10.1007/s10549-012-2385-x – volume: 33 start-page: 564 year: 2019 ident: B33 article-title: Evaluation of the effects of chemotherapy on brain glucose metabolism in children with Hodgkin’s lymphoma. publication-title: Ann. Nucl. Med. doi: 10.1007/s12149-019-01363-8 – volume: 10 year: 2020 ident: B24 article-title: Hippocampus-Related Cognitive and Affective Impairments in Patients With Breast Cancer-A Systematic Review. publication-title: Front. Oncol. doi: 10.3389/fonc.2020.00147 – volume: 9 start-page: 1776 year: 2019 ident: B6 article-title: The dorsolateral prefrontal cortex is selectively involved in chemotherapy-related cognitive impairment in breast cancer patients with different hormone receptor expression. publication-title: Am. J. Cancer Res. – volume: 42 start-page: 328 year: 2015 ident: B4 article-title: FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. publication-title: Eur. J. Nucl. Med. Mol. Imaging doi: 10.1007/s00259-014-2961-x – volume: 27 start-page: 2137 year: 2017 ident: B39 article-title: Resting-state fMRI revealed different brain activities responding to valproic acid and levetiracetam in benign epilepsy with central-temporal spikes. publication-title: Eur. Radiol. doi: 10.1007/s00330-016-4531-z – volume: 38 start-page: 1875 year: 2020 ident: B35 article-title: Patient-Reported Cognitive Impairment Among Women With Early Breast Cancer Randomly Assigned to Endocrine Therapy Alone Versus Chemoendocrine Therapy: Results From TAILORx. publication-title: J. Clin. Oncol. doi: 10.1200/Jco.19.01866 – volume: 132 start-page: 1099 year: 2012 ident: B16 article-title: Global and focal brain volume in long-term breast cancer survivors exposed to adjuvant chemotherapy. publication-title: Breast Cancer Res. Treat. doi: 10.1007/s10549-011-1888-1 – volume: 56 start-page: 559 year: 2012 ident: B3 article-title: The chemotherapy long-term effect on cognitive functions and brain metabolism in lymphoma patients. publication-title: Q. J. Nucl. Med. Mol. Imaging |
| SSID | ssj0062842 |
| Score | 2.3230617 |
| Snippet | Background: A growing number of neuroimaging studies reported that chemotherapy might impair brain functions, leading to persistent cognitive alterations in a... A growing number of neuroimaging studies reported that chemotherapy might impair brain functions, leading to persistent cognitive alterations in a subset of... BackgroundA growing number of neuroimaging studies reported that chemotherapy might impair brain functions, leading to persistent cognitive alterations in a... |
| SourceID | doaj pubmedcentral proquest crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Enrichment Source Index Database |
| StartPage | 914556 |
| SubjectTerms | 18F-FDG B-cell lymphoma Brain cancer brain glucose metabolism Brain research Breast cancer Chemotherapy Cognitive ability Computed tomography Cyclophosphamide Deoxyglucose Diabetes diffuse large B cell lymphoma Education Epirubicin Frontal gyrus Glucose Glucose metabolism Handedness Hippocampus Lymphocytes B Lymphoma Magnetic resonance imaging Medical research Metabolism Neuroimaging Neuroscience Parahippocampal gyrus PET Positron emission tomography Prednisone Research methodology Scanning Tomography Vincristine |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9MwELbQigMXBCyIwoIGCXFAG9Z52TG3trRwWFYVKrC3yE5sGil1qj4Q_bn8E2aSbLW9wIVbZTup45nMw_7yDWOvObqQVJsykCZOgkTLMDBFkQRap8KIpORcm7bYhLy6yq6v1exWqS_ChHX0wN3CXUirNTplURqNwWyqTMFNWUTSxmGRyqQk68ulukmmOhss0OhG3RkmpmDqwvnKEzd3FL1TxMwtjrxQS9Z_FGEe4yNvOZzpA3a_jxRh2M3wIbtj_SN2OvSYJS_38AZa7Ga7KX7Kfg_p0NuW8MX-aPf2YESlH-BjB0iHz3aLwq6rzRKw9UPl3A5bLwkFDqNgbOsaLvco12apYdYxrW5gTvEk3vN7tV3AeF_UDQ7YrBZ6WZX2HCarar0zdDB_Dt8qX7TWwmOH9iXMcDKegEr2PQw9TOtdg5baNr_2PUYeZoQWWzceJqhptGUH82bZ82cDoRv30DiIeApjdLSbx-zrdDIffwr64g1BkUi-DbRLtcZoULlMaJli5mIiFWGCJ2PNndDOhNw4kTqOPw1XkhvaoHbCFjIM4zJ-wk48zvIpA8xphM1cEiUO4z1NHxOHWpVZmmmVRKEeMH4jzLzomc2pwEadY4ZD8s9b-eck_7yT_4C9PVyy6mg9_jZ4RBpyGEiM3G0D6mne62n-Lz0dsLMb_cp7M4F_IqSgimBRPGCvDt247HRqo71tdjQmS8nyKj5g8kgvjyZ03OOrRUsVrohuMUue_Y8neM7u0aIQTi5Mz9jJdr2zL9jd4ue22qxftu_fHzy-PKM priority: 102 providerName: Directory of Open Access Journals |
| Title | Altered Regional Brain Glucose Metabolism in Diffuse Large B-Cell Lymphoma Patients Treated With Cyclophosphamide, Epirubicin, Vincristine, and Prednisone: An Fluorodeoxyglucose Positron Emission Tomography Study of 205 Cases |
| URI | https://www.proquest.com/docview/2676690123 https://www.proquest.com/docview/2685031890 https://pubmed.ncbi.nlm.nih.gov/PMC9240384 https://doaj.org/article/7eaa6006dba04959bc0bdc27e31c574d |
| Volume | 16 |
| WOSCitedRecordID | wos000817983900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1662-453X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0062842 issn: 1662-453X databaseCode: DOA dateStart: 20070101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9NAEF7RlgMXHi2ogRINEuKAarp27F2bC0pCCkhNZFUFysnatXdbS4kd8kDk5_JPmNk4Ebn0wsWKdjfxJvoyO4_P3zD2muMREildeFJ3Qi9U0vd0noeeUpHQIiw4V9o1m5CjUXx9naRNwm3e0Co3NtEZ6qLOKUd-FggpqHlS0Pkw_elR1yiqrjYtNPbYAXo2PlG6hkG6scQCTa-rdgp6Mghd83VVE4Oy5MxWZUVq3UHwLiGtbrFzLjn5_h2fc5cx-c8RdP7ofzf_mD1snE_ortHyhN0z1SE76lYYeE9W8AYcHdTl2Q-pnXND_Thif7pUUzcFXJoblzqEHnWWgE9rvjsMzQKxNC7nE8DRj6W1Sxy9IJI59Ly-GY_hYoWwqScK0rWQ6xyuyF3Fz_xeLm6hv8rHNS6YT2_VpCzMKQym5Wypqe5_Ct_KKnfGqMIJVRWQ4mYq4kGZ99Ct4Hy8rPEgMPXvVUPBh5TIaLO6ggECmTKCcFVPGnluIPLkCmoLAY-gj-f4_Cn7ej646n_2mt4QXh5KvvCUjZRCZzOxsVAywsBIB0mA8aPsKG6Fstrn2orIcnypeSK5pvy3FSaXvt8pOs_YfoW7PGaAIZMwsQ2D0KI7qehZZV8lRRzFKgkDX7UY3yAjyxvhdOrfMc4wgCIwZQ5MGYEpW4Opxd5u3zJdq4bctbhHcNsuJMFvN1DPbrLGfmTSKIW-qSi0wpguSnTOdZEH0nT8PJJh0WInG-RljRXCm2xh12KvttP4s1NRSFWmXtKaOCLDnvAWkzsg39nQ7kxV3jol8oTUHOPw-d03f8Ee0Nclgp0fnbD9xWxpXrL7-a9FOZ-12Z68jtvsoDcYpZdtlxNpu78xXSVeD9Ivw_THX2BIVao |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1fb9MwELfGQIIX_mwgCgMOCXhAC0vcxE6QEGq7jU3rpgp1sLdgJ_YaqU1K_wD9Unwnvgl3SVrRl73tgbfKdhPXvTvf-X7-HWOvXNxCAqVTR-qm7_hKeo5OEt9RKhBa-KnrKl0Wm5BnZ-HFRdTbYL-Xd2EIVrm0iaWhTouEzsj3uJCCiifx5sfxd4eqRlF2dVlCoxKLE7P4iSHb9MPxPv6_rzk_POh3jpy6qoCT-NKdOcoGSqGbEtlQKBmgS615xDHykE3lWqGs9lxtRWBd_KjdSLqaTk6tMIn0vGbaxOfeYDd9YhYjqCDvLS2_QFNfZlcF3UTCUKDKomIQGO3ZPMuJHZzzdxFxg4u1fbAsF7Dm464jNP_Z8g7v_W-LdZ_drZ1raFXa8IBtmHyLbbdyNStGC3gDJdy1zCNsUbnqGtqyzf60CDNgUvhsLsujUWhT5Qz4VOH54dTMUFeG2XQE2LqfWTvH1i6B6KHtdMxwCN0FqkUxUtCriGqn0Cd3HJ_5NZsNoLNIhgUOmI4HapSlZhcOxtlkrgnXsAtfsjwpjW2OHSpPoYeTyQnnZd5DK4fD4bzAjc4Uvxb1FQPoEdhuUuRwgIpKJ57QL0Y1_TgQOHQBhQXuBtBBP2X6kJ1fy8I_Yps5zvIxAwwJhQmtz32L7rKiu9ieitIwCFXkc081mLuUxDipieGpPskwxgCRhDcuhTcm4Y0r4W2wt6uvjCtWlKsGt0m8VwOJ0LxsKCaXcW0fY2mUQt9bpFphzBpEOnF1mnBpml4SSD9tsJ2lpMe1lcWXrMS8wV6uunHZKemlclPMaUwY0MYVuQ0m15RqbULrPXk2KJnWI2KrDP0nV7_8Bbt91D_txt3js5On7A79dAITesEO25xN5uYZu5X8mGXTyfPSXAD7dt0q9xdAdqvb |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELZKixAXHi2IhQKDBBxQwzrexEmQENpuu1D1oQgVKKdgJ3YbaTdZ9gHsX-Pf8E-YSbIr9tJbD9wi20kcZ56ezzOMPeeoQnylMyfQHc_xVOA6Ok09RylfaullnCtdFZsITk7Cs7MoXmO_F2dhCFa5kImVoM7KlPbI20IGkooniU7bNrCIeK__bvTdoQpSFGldlNOoSeTQzH-i-zZ5e7CH__qFEP39094Hp6kw4KRewKeOsr5SaLJENpQq8NG81iIS6IUEHcWtVFa7XFvpW46XmkcB17SLaqVJA9ftZB187jW2gSa5J9bZRnxwHH9d6AGJgr-KtUo6l4SOQR1TRZcwatsiLyhXuBCvI8oULle0YlU8YMXiXcVr_qMA-7f_56W7w241Zjd0az65y9ZMscm2uoWalsM5vIQKCFtFGDapkHUDetlif7qEJjAZfDTn1aYp7FJNDXhfI_3h2EyRiwb5ZAjYupdbO8PWI4LXw67TM4MBHM2RYcqhgrhOYTuBUzLU8Zlf8ukF9ObpoMQBk9GFGuaZ2YH9UT6eaUI87MDnvEgrMVxghyoyiHEyBSHAzBvoFtAfzEpUgab8NW8OH0BMMLxxWcA-sjDthcJpOWwSkwPBRudQWhDchx5aMJN77NOVLPx9tl7gLB8wQGdRmtB6wrNoSCs6pe2qKAv9UEWecFWL8QVVJmmTMp4qlwwSdB2JkJOKkBMi5KQm5BZ7tbxlVOdLuWzwLpH6ciClOq8ayvF50kjOJDBKoVUuM63Qm_UjnXKdpSIwHTf1Ay9rse0F1SeN_MWXLEm-xZ4tu3HZKRymClPOaEzok0qLeIsFKwy2MqHVniK_qHKwR5THMvQeXv7yp-wGclpydHBy-IjdpC8nlKHrb7P16XhmHrPr6Y9pPhk_aWQHsG9XzXN_AZJftiQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Altered+Regional+Brain+Glucose+Metabolism+in+Diffuse+Large+B-Cell+Lymphoma+Patients+Treated+With+Cyclophosphamide%2C+Epirubicin%2C+Vincristine%2C+and+Prednisone%3A+An+Fluorodeoxyglucose+Positron+Emission+Tomography+Study+of+205+Cases&rft.jtitle=Frontiers+in+neuroscience&rft.au=Hu%2C+Yuxiao&rft.au=Zhang%2C+Qin&rft.au=Cui%2C+Can&rft.au=Zhang%2C+Yun&rft.date=2022-06-15&rft.pub=Frontiers+Research+Foundation&rft.issn=1662-4548&rft.eissn=1662-453X&rft_id=info:doi/10.3389%2Ffnins.2022.914556&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1662-453X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1662-453X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1662-453X&client=summon |