Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome

In light of growing evidence highlighting interactions between cardiac and brain health, we investigated associations of biomarkers of neurodegenerative diseases with adverse outcomes (all-cause and cardiovascular mortality, major cardiovascular events, and stroke) in persons with chronic coronary s...

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Veröffentlicht in:Experimental gerontology Jg. 200; S. 112684
Hauptverfasser: Lohner, Valerie, Perna, Laura, Schöttker, Ben, Perneczky, Robert, Brenner, Hermann, Mons, Ute
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Inc 01.02.2025
Elsevier
Schlagworte:
Aged
Amyloid beta-Peptides - blood
Biomarkers - blood
Blood-based biomarkers of neurodegenerative diseases
Cerebrovascular Disorders - blood
Cerebrovascular events
Chronic coronary syndrome
Coronary heart disease
Epidemiology
Female
Glial Fibrillary Acidic Protein - blood
Humans
Major cardiovascular events
Male
Middle Aged
Mortality
Neurodegenerative Diseases - blood
Neurofilament Proteins - blood
Proportional Hazards Models
Stroke - blood
tau Proteins - blood
Cerebrovascular events
Mortality
Blood-based biomarkers of neurodegenerative diseases
Chronic coronary syndrome
Major cardiovascular events
Coronary heart disease
Epidemiology
ISSN:0531-5565, 1873-6815, 1873-6815
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Zusammenfassung:In light of growing evidence highlighting interactions between cardiac and brain health, we investigated associations of biomarkers of neurodegenerative diseases with adverse outcomes (all-cause and cardiovascular mortality, major cardiovascular events, and stroke) in persons with chronic coronary syndrome (CCS). We used data from a cohort of persons with CCS for whom major adverse events were recorded over a follow-up of 20 years. We measured biomarkers of neurodegenerative diseases in baseline blood samples, using the Single-Molecule Array Technology on a HD-1 Analyzer. These include biomarkers of neuronal (neurofilament light chain (NfL) (n = 379)) and glial neurodegeneration (glial fibrillary acidic protein (GFAP) (n = 379)), and Alzheimer's disease pathology (phosphorylated tau181 (n = 379), total tau (n = 377), and amyloid β (Aβ40, Aβ42, Aβ42/Aβ40) (n = 377)). We applied Cox-proportional hazards models to evaluate associations of these biomarkers with adverse outcomes, adjusting for covariates and exploring interactions with apolipoprotein E (ApoE) ε4 genotype. Participants with higher NfL levels had increased rates of all-cause and cardiovascular mortality (Hazard ratio per increase by one standard deviation (95 % confidence interval): all-cause mortality: 1.36 (1.10–1.68); cardiovascular mortality: 1.42 (1.05–1.93)). The Aβ40/Aβ42-ratio was linked to incident stroke (0.72 (0.52–1.00)). Associations of GFAP with all-cause mortality and incident stroke were depending on ApoE ε4 genotype. The other biomarkers were not significantly associated with the studied outcomes. In persons with CSS, NfL and the Aβ40/Aβ42-ratio were related to mortality and incident stroke, respectively, whereas associations of GFAP with adverse outcomes varied by ApoE genotype. These biomarkers might play a role in linking aging, cardiovascular and neurodegenerative diseases. •We explored markers of 20-year adverse outcomes in persons with chronic coronary syndrome.•Neurofilament light chain was associated with all-cause and cardiovascular mortality.•The Aβ40/Aβ42-ratio was linked to incident stroke.•Associations of glial fibrillary acidic protein with all-cause mortality and incident stroke varied by ApoE genotype.•These biomarkers might link cardiovascular and cerebral health.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0531-5565
1873-6815
1873-6815
DOI:10.1016/j.exger.2025.112684