Molecular subtypes of pancreatic cancer
Cancers that appear morphologically similar often have dramatically different clinical features, respond variably to therapy and have a range of outcomes. Compelling evidence now demonstrates that differences in the molecular pathology of otherwise indistinguishable cancers substantially impact the...
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| Veröffentlicht in: | Nature reviews. Gastroenterology & hepatology Jg. 16; H. 4; S. 207 - 220 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
London
Nature Publishing Group UK
01.04.2019
Nature Publishing Group |
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| ISSN: | 1759-5045, 1759-5053, 1759-5053 |
| Online-Zugang: | Volltext |
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| Abstract | Cancers that appear morphologically similar often have dramatically different clinical features, respond variably to therapy and have a range of outcomes. Compelling evidence now demonstrates that differences in the molecular pathology of otherwise indistinguishable cancers substantially impact the clinical characteristics of the disease. Molecular subtypes now guide preclinical and clinical therapeutic development and treatment in many cancer types. The ability to predict optimal therapeutic strategies ahead of treatment improves overall patient outcomes, minimizing treatment-related morbidity and cost. Although clinical decision making based on histopathological criteria underpinned by robust data is well established in many cancer types, subtypes of pancreatic cancer do not currently inform treatment decisions. However, accumulating molecular data are defining subgroups in pancreatic cancer with distinct biology and potential subtype-specific therapeutic vulnerabilities, providing the opportunity to define a de novo clinically applicable molecular taxonomy. This Review summarizes current knowledge concerning the molecular subtyping of pancreatic cancer and explores future strategies for using a molecular taxonomy to guide therapeutic development and ultimately routine therapy with the overall goal of improving outcomes for this disease.
This Review summarizes current knowledge concerning the molecular subtyping of pancreatic cancer and explores future strategies using molecular taxonomy to guide therapeutic development and therapy with the overall goal of improving outcomes for this disease.
Key points
Pancreatic cancer is soon to become the second leading cause of cancer-related death.
Histopathological criteria do not adequately inform treatment decisions for pancreatic cancer.
A molecular taxonomy could improve outcomes with current treatments and accelerate therapeutic development through better patient selection.
Emerging molecular taxonomies define biological differences between subtypes that are associated with prognosis.
Genomic and transcriptomic subtypes potentially enrich for therapeutic vulnerabilities and require preclinical and clinical assessment. |
|---|---|
| AbstractList | Cancers that appear morphologically similar often have dramatically different clinical features, respond variably to therapy and have a range of outcomes. Compelling evidence now demonstrates that differences in the molecular pathology of otherwise indistinguishable cancers substantially impact the clinical characteristics of the disease. Molecular subtypes now guide preclinical and clinical therapeutic development and treatment in many cancer types. The ability to predict optimal therapeutic strategies ahead of treatment improves overall patient outcomes, minimizing treatment-related morbidity and cost. Although clinical decision making based on histopathological criteria underpinned by robust data is well established in many cancer types, subtypes of pancreatic cancer do not currently inform treatment decisions. However, accumulating molecular data are defining subgroups in pancreatic cancer with distinct biology and potential subtype-specific therapeutic vulnerabilities, providing the opportunity to define a de novo clinically applicable molecular taxonomy. This Review summarizes current knowledge concerning the molecular subtyping of pancreatic cancer and explores future strategies for using a molecular taxonomy to guide therapeutic development and ultimately routine therapy with the overall goal of improving outcomes for this disease. This Review summarizes current knowledge concerning the molecular subtyping of pancreatic cancer and explores future strategies using molecular taxonomy to guide therapeutic development and therapy with the overall goal of improving outcomes for this disease. Key points Pancreatic cancer is soon to become the second leading cause of cancer-related death. Histopathological criteria do not adequately inform treatment decisions for pancreatic cancer. A molecular taxonomy could improve outcomes with current treatments and accelerate therapeutic development through better patient selection. Emerging molecular taxonomies define biological differences between subtypes that are associated with prognosis. Genomic and transcriptomic subtypes potentially enrich for therapeutic vulnerabilities and require preclinical and clinical assessment. Cancers that appear morphologically similar often have dramatically different clinical features, respond variably to therapy and have a range of outcomes. Compelling evidence now demonstrates that differences in the molecular pathology of otherwise indistinguishable cancers substantially impact the clinical characteristics of the disease. Molecular subtypes now guide preclinical and clinical therapeutic development and treatment in many cancer types. The ability to predict optimal therapeutic strategies ahead of treatment improves overall patient outcomes, minimizing treatment-related morbidity and cost. Although clinical decision making based on histopathological criteria underpinned by robust data is well established in many cancer types, subtypes of pancreatic cancer do not currently inform treatment decisions. However, accumulating molecular data are defining subgroups in pancreatic cancer with distinct biology and potential subtype-specific therapeutic vulnerabilities, providing the opportunity to define a de novo clinically applicable molecular taxonomy. This Review summarizes current knowledge concerning the molecular subtyping of pancreatic cancer and explores future strategies for using a molecular taxonomy to guide therapeutic development and ultimately routine therapy with the overall goal of improving outcomes for this disease.Cancers that appear morphologically similar often have dramatically different clinical features, respond variably to therapy and have a range of outcomes. Compelling evidence now demonstrates that differences in the molecular pathology of otherwise indistinguishable cancers substantially impact the clinical characteristics of the disease. Molecular subtypes now guide preclinical and clinical therapeutic development and treatment in many cancer types. The ability to predict optimal therapeutic strategies ahead of treatment improves overall patient outcomes, minimizing treatment-related morbidity and cost. Although clinical decision making based on histopathological criteria underpinned by robust data is well established in many cancer types, subtypes of pancreatic cancer do not currently inform treatment decisions. However, accumulating molecular data are defining subgroups in pancreatic cancer with distinct biology and potential subtype-specific therapeutic vulnerabilities, providing the opportunity to define a de novo clinically applicable molecular taxonomy. This Review summarizes current knowledge concerning the molecular subtyping of pancreatic cancer and explores future strategies for using a molecular taxonomy to guide therapeutic development and ultimately routine therapy with the overall goal of improving outcomes for this disease. Cancers that appear morphologically similar often have dramatically different clinical features, respond variably to therapy and have a range of outcomes. Compelling evidence now demonstrates that differences in the molecular pathology of otherwise indistinguishable cancers substantially impact the clinical characteristics of the disease. Molecular subtypes now guide preclinical and clinical therapeutic development and treatment in many cancer types. The ability to predict optimal therapeutic strategies ahead of treatment improves overall patient outcomes, minimizing treatment-related morbidity and cost. Although clinical decision making based on histopathological criteria underpinned by robust data is well established in many cancer types, subtypes of pancreatic cancer do not currently inform treatment decisions. However, accumulating molecular data are defining subgroups in pancreatic cancer with distinct biology and potential subtype-specific therapeutic vulnerabilities, providing the opportunity to define a de novo clinically applicable molecular taxonomy. This Review summarizes current knowledge concerning the molecular subtyping of pancreatic cancer and explores future strategies for using a molecular taxonomy to guide therapeutic development and ultimately routine therapy with the overall goal of improving outcomes for this disease.This Review summarizes current knowledge concerning the molecular subtyping of pancreatic cancer and explores future strategies using molecular taxonomy to guide therapeutic development and therapy with the overall goal of improving outcomes for this disease. Cancers that appear morphologically similar often have dramatically different clinical features, respond variably to therapy and have a range of outcomes. Compelling evidence now demonstrates that differences in the molecular pathology of otherwise indistinguishable cancers substantially impact the clinical characteristics of the disease. Molecular subtypes now guide preclinical and clinical therapeutic development and treatment in many cancer types. The ability to predict optimal therapeutic strategies ahead of treatment improves overall patient outcomes, minimizing treatment-related morbidity and cost. Although clinical decision making based on histopathological criteria underpinned by robust data is well established in many cancer types, subtypes of pancreatic cancer do not currently inform treatment decisions. However, accumulating molecular data are defining subgroups in pancreatic cancer with distinct biology and potential subtype-specific therapeutic vulnerabilities, providing the opportunity to define a de novo clinically applicable molecular taxonomy. This Review summarizes current knowledge concerning the molecular subtyping of pancreatic cancer and explores future strategies for using a molecular taxonomy to guide therapeutic development and ultimately routine therapy with the overall goal of improving outcomes for this disease. This Review summarizes current knowledge concerning the molecular subtyping of pancreatic cancer and explores future strategies using molecular taxonomy to guide therapeutic development and therapy with the overall goal of improving outcomes for this disease. Key points Pancreatic cancer is soon to become the second leading cause of cancer-related death. Histopathological criteria do not adequately inform treatment decisions for pancreatic cancer. A molecular taxonomy could improve outcomes with current treatments and accelerate therapeutic development through better patient selection. Emerging molecular taxonomies define biological differences between subtypes that are associated with prognosis. Genomic and transcriptomic subtypes potentially enrich for therapeutic vulnerabilities and require preclinical and clinical assessment. Cancers that appear morphologically similar often have dramatically different clinical features, respond variably to therapy and have a range of outcomes. Compelling evidence now demonstrates that differences in the molecular pathology of otherwise indistinguishable cancers substantially impact the clinical characteristics of the disease. Molecular subtypes now guide preclinical and clinical therapeutic development and treatment in many cancer types. The ability to predict optimal therapeutic strategies ahead of treatment improves overall patient outcomes, minimizing treatment-related morbidity and cost. Although clinical decision making based on histopathological criteria underpinned by robust data is well established in many cancer types, subtypes of pancreatic cancer do not currently inform treatment decisions. However, accumulating molecular data are defining subgroups in pancreatic cancer with distinct biology and potential subtype-specific therapeutic vulnerabilities, providing the opportunity to define a de novo clinically applicable molecular taxonomy. This Review summarizes current knowledge concerning the molecular subtyping of pancreatic cancer and explores future strategies for using a molecular taxonomy to guide therapeutic development and ultimately routine therapy with the overall goal of improving outcomes for this disease. |
| Audience | Academic |
| Author | Bailey, Peter Chang, David K. Collisson, Eric A. Biankin, Andrew V. |
| Author_xml | – sequence: 1 givenname: Eric A. surname: Collisson fullname: Collisson, Eric A. organization: University of California, San Francisco – sequence: 2 givenname: Peter surname: Bailey fullname: Bailey, Peter organization: Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate – sequence: 3 givenname: David K. surname: Chang fullname: Chang, David K. organization: Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, West of Scotland Pancreatic Unit, Glasgow Royal Infirmary – sequence: 4 givenname: Andrew V. orcidid: 0000-0002-0362-5597 surname: Biankin fullname: Biankin, Andrew V. email: andrew.biankin@glasgow.ac.uk organization: Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30718832$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/s41436-018-0009-5 10.15252/emmm.201404827 10.1038/nm.3174 10.1016/j.gde.2013.12.001 10.1136/gutjnl-2016-313133 10.1101/198903 10.1093/jnci/djp020 10.1016/S1470-2045(16)30559-9 10.1136/gutjnl-2012-303108 10.1016/j.ccell.2018.02.003 10.1038/ncomms7744 10.1038/ng.3934 10.1200/JCO.2017.72.3502 10.1038/nature16965 10.1038/ng.3398 10.1158/1078-0432.CCR-17-0899 10.1158/2159-8290.CD-14-0617 10.1038/nm.2344 10.1158/0008-5472.CAN-16-0899 10.1053/j.gastro.2009.04.009 10.1038/sj.bjc.6601894 10.1053/j.gastro.2014.11.042 10.1371/journal.pmed.1001453 10.1038/nature14169 10.1172/JCI40045 10.1158/0008-5472.CAN-14-0155 10.1007/s00534-013-0610-6 10.1158/1078-0432.CCR-16-2411 10.1038/nm.4292 10.1038/35021093 10.1093/annonc/mdw192 10.1158/2159-8290.CD-18-0275 10.1038/nature10760 10.1038/nrc3723 10.1182/blood-2017-08-803353 10.1097/PAS.0000000000000533 10.1016/j.ejso.2018.10.024 10.1186/gm482 10.1038/nature07385 10.1038/nm.3175 10.18632/oncotarget.20492 10.1053/j.gastro.2013.08.053 10.1016/j.ccell.2015.09.020 10.1158/1078-0432.CCR-17-2994 10.1093/annonc/mdr561 10.1002/path.4310 10.1111/pcmr.12148 10.1016/j.ccell.2016.02.010 10.1002/path.4042 10.1158/1055-9965.EPI-15-1217 10.1038/modpathol.2014.100 10.1093/nar/gkq929 10.1371/journal.pone.0074380 10.1053/j.seminoncol.2016.09.002 10.1016/j.ejca.2005.04.044 10.1159/000441557 10.1136/gutjnl-2013-306202 10.1002/ijc.28765 10.1158/1078-0432.CCR-17-3099 10.1001/jamaoncol.2016.3916 10.1126/science.1171202 10.1038/nature15819 10.1093/bioinformatics/btt755 10.1038/nature12477 10.1016/j.ccell.2017.07.007 10.1016/j.ydbio.2006.06.046 10.1126/science.1235122 10.1016/j.ccr.2012.10.025 10.1038/nature08987 10.1093/nar/16.16.7773 10.1002/jso.23194 10.1038/nmeth.4407 10.2353/ajpath.2010.090899 10.1038/nature13385 10.1056/NEJMra031623 10.1126/scitranslmed.3002003 10.1097/MPA.0000000000000392 10.1136/gut.2010.236026 10.1136/gut.2008.171611 10.1053/j.gastro.2018.08.033 10.1056/NEJMoa1105535 10.1097/PAS.0000000000000169 10.1038/nm.4038 10.1111/pcmr.12388 10.1038/modpathol.3880332 10.1002/cncr.28863 10.1371/journal.pmed.1002223 10.3322/caac.21387 10.1007/s00439-011-1010-0 10.1093/jnci/djp466 10.1097/01.pas.0000126675.59108.80 10.1038/nrdp.2016.22 10.1016/j.celrep.2018.03.131 10.1126/science.1164368 10.1038/nature24462 10.1016/j.suc.2015.05.003 10.1016/S1470-2045(17)30679-4 10.1038/nature11547 10.1016/j.cell.2014.06.049 10.1053/j.gastro.2015.01.009 10.1002/humu.21633 10.1053/j.gastro.2015.07.041 10.1158/0008-5472.CAN-03-3823 10.1016/j.cell.2014.01.066 10.1016/j.ccell.2016.04.014 10.1038/35000501 10.1053/j.gastro.2016.09.060 10.1200/JCO.2008.17.7188 10.1038/nm.3967 10.1056/NEJM200103153441101 10.1136/gutjnl-2018-316151 10.1038/nature09454 |
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| References | Rahib (CR9) 2014; 74 Jones (CR52) 2008; 321 Petersen (CR14) 2016; 43 Shindo (CR23) 2017; 35 Iacobuzio-Donahue (CR113) 2011; 61 Hall (CR117) 2016; 14 Iacobuzio-Donahue (CR45) 2009; 27 Cowley (CR61) 2013; 20 Perou (CR84) 2000; 406 Niu (CR43) 2014; 30 Smit (CR50) 1988; 16 Morran (CR67) 2014; 63 Decker, Goldman, Grasch, Sussel (CR90) 2006; 298 Planchard (CR65) 2017; 18 Vogelstein (CR92) 2013; 339 Hruban (CR33) 2004; 28 Steele (CR103) 2016; 29 Yurgelun (CR25) 2018 Kassahn (CR93) 2013; 8 Connor (CR121) 2017; 3 McBride (CR76) 2012; 227 Wolpin (CR19) 2009; 101 Hollingsworth, Biankin (CR5) 2015; 18 Basturk (CR31) 2014; 38 CR41 Furukawa (CR115) 2015; 5 De Sousa (CR86) 2013; 19 Waddell (CR55) 2015; 518 Biankin, Hudson (CR3) 2011; 130 Lowery (CR72) 2017; 23 Marisa (CR87) 2013; 10 Nones (CR95) 2014; 135 Brune (CR16) 2010; 102 Davies (CR78) 2017; 23 Miller (CR69) 2015; 7 Jones (CR17) 2009; 324 Siegel, Miller, Jemal (CR8) 2017; 67 Polak (CR77) 2017; 49 Swisher (CR82) 2017; 18 Collisson (CR89) 2011; 17 Bollag (CR64) 2010; 467 (CR60) 2017; 32 Slamon (CR63) 2001; 344 Basturk (CR32) 2015; 39 Kleeff (CR62) 2016; 2 Qian (CR49) 2018; 4 Aung (CR122) 2017; 24 Jiao (CR116) 2014; 232 Andricovich (CR110) 2018; 33 Swanton (CR6) 2016; 27 Moffitt (CR58) 2015; 47 Noll (CR99) 2016; 22 Habib (CR107) 2017; 14 Scarpa, Real, Luchini (CR36) 2018; 67 Chang, Grimmond, Evans, Biankin (CR74) 2014; 14 McWilliams (CR28) 2016; 45 Bailey (CR56) 2016; 531 Kardon, Thompson, Przygodzki, Heffess (CR30) 2001; 14 Biankin, Maitra (CR97) 2015; 28 Humphris (CR18) 2014; 120 Weissmueller (CR68) 2014; 157 Menzies (CR119) 2015; 28 Humphris (CR42) 2017; 152 Kim (CR112) 2017; 8 Chang, Grimmond, Biankin (CR54) 2014; 24 Humphris, Chang, Biankin (CR24) 2015; 148 Kloppel, Luttges (CR29) 2001; 85 Zhao (CR106) 2017; 130 Sadanandam (CR85) 2013; 19 Balachandran (CR35) 2017; 551 Hudson (CR1) 2010; 464 Alexandrov (CR13) 2013; 500 Puleo (CR98) 2018; 155 Biankin (CR40) 2009; 137 Forbes (CR80) 2011; 39 Jamieson, Chang, Biankin (CR91) 2015; 95 Sequist (CR114) 2011; 3 Springer (CR37) 2015; 149 CR7 Pishvaian, Brody (CR39) 2017; 31 Hu (CR20) 2018; 24 Witkiewicz (CR59) 2015; 6 Reid, Bagci, Adsay (CR38) 2013; 107 Biankin (CR53) 2012; 491 Morris, Cano, Sekine, Wang, Hebrok (CR102) 2010; 120 CR123 Delgiorno (CR109) 2014; 146 CR81 Foster (CR73) 2016; 29 Hoadley (CR96) 2014; 158 Agaimy (CR120) 2015; 28 (CR2) 2008; 455 Klein (CR15) 2004; 64 Brugge, Lauwers, Sahani, Fernandez-del Castillo, Warshaw (CR34) 2004; 351 Chou (CR70) 2013; 5 Dreyer (CR46) 2017; 44 Bamford (CR79) 2004; 91 Ledermann (CR66) 2012; 366 Aguirre (CR48) 2018; 8 (CR12) 2014; 511 Biankin, Piantadosi, Hollingsworth (CR4) 2015; 526 Sinha (CR108) 2017; 77 Lord, Ashworth (CR75) 2012; 481 Langer (CR27) 2009; 58 Humphris (CR47) 2012; 23 CR10 Alizadeh (CR83) 2000; 403 Candido (CR104) 2018; 23 Canto (CR26) 2013; 62 Grant (CR22) 2014; 148 Ryan, Hong, Bardeesy (CR11) 2014; 371 Dreyer, Chang, Bailey, Biankin (CR57) 2017; 23 Kopp (CR101) 2012; 22 Xu (CR105) 2010; 177 Botton (CR118) 2013; 26 Knudsen (CR100) 2017; 67 Garcea, Neal, Pattenden, Steward, Berry (CR44) 2005; 41 Sivakumar, de Santiago, Chlon, Markowetz (CR111) 2017; 14 Chmielecki (CR71) 2014; 4 Childs (CR21) 2016; 25 Guinney (CR88) 2015; 21 Song (CR94) 2012; 7 Jones (CR51) 2012; 33 A Sadanandam (109_CR85) 2013; 19 EA Collisson (109_CR89) 2011; 17 C Swanton (109_CR6) 2016; 27 S Sinha (109_CR108) 2017; 77 109_CR10 BW Miller (109_CR69) 2015; 7 DJ McBride (109_CR76) 2012; 227 VT Smit (109_CR50) 1988; 16 L Rahib (109_CR9) 2014; 74 AV Biankin (109_CR3) 2011; 130 N Waddell (109_CR55) 2015; 518 KE Delgiorno (109_CR109) 2014; 146 S Jones (109_CR52) 2008; 321 N Habib (109_CR107) 2017; 14 X Zhao (109_CR106) 2017; 130 MJ Cowley (109_CR61) 2013; 20 S Bamford (109_CR79) 2004; 91 109_CR81 K Nones (109_CR95) 2014; 135 J Kleeff (109_CR62) 2016; 2 AM Menzies (109_CR119) 2015; 28 The Cancer Genome Atlas Research Network (109_CR2) 2008; 455 DC Morran (109_CR67) 2014; 63 H Davies (109_CR78) 2017; 23 G Kloppel (109_CR29) 2001; 85 RH Hruban (109_CR33) 2004; 28 MB Yurgelun (109_CR25) 2018 AA Alizadeh (109_CR83) 2000; 403 ES Knudsen (109_CR100) 2017; 67 J Andricovich (109_CR110) 2018; 33 RA Moffitt (109_CR58) 2015; 47 B Niu (109_CR43) 2014; 30 AP Klein (109_CR15) 2004; 64 AK Witkiewicz (109_CR59) 2015; 6 109_CR123 LV Sequist (109_CR114) 2011; 3 A Agaimy (109_CR120) 2015; 28 JL Humphris (109_CR42) 2017; 152 S Sivakumar (109_CR111) 2017; 14 J Chmielecki (109_CR71) 2014; 4 The Cancer Genome Atlas Research Network (109_CR12) 2014; 511 D Planchard (109_CR65) 2017; 18 SB Dreyer (109_CR46) 2017; 44 G Garcea (109_CR44) 2005; 41 WR Brugge (109_CR34) 2004; 351 JL Humphris (109_CR18) 2014; 120 S Jones (109_CR17) 2009; 324 AJ Aguirre (109_CR48) 2018; 8 DK Chang (109_CR54) 2014; 24 RC Grant (109_CR22) 2014; 148 T Botton (109_CR118) 2013; 26 G Bollag (109_CR64) 2010; 467 S Song (109_CR94) 2012; 7 EM Noll (109_CR99) 2016; 22 MA Lowery (109_CR72) 2017; 23 DE Kardon (109_CR30) 2001; 14 SJ Hollingsworth (109_CR5) 2015; 18 F Puleo (109_CR98) 2018; 155 ZI Hu (109_CR20) 2018; 24 RL Siegel (109_CR8) 2017; 67 KA Hoadley (109_CR96) 2014; 158 TJ Hudson (109_CR1) 2010; 464 CW Steele (109_CR103) 2016; 29 Z Xu (109_CR105) 2010; 177 EJ Childs (109_CR21) 2016; 25 109_CR7 MD Reid (109_CR38) 2013; 107 AV Biankin (109_CR40) 2009; 137 T Furukawa (109_CR115) 2015; 5 A Chou (109_CR70) 2013; 5 P Langer (109_CR27) 2009; 58 109_CR41 SA Foster (109_CR73) 2016; 29 KS Kassahn (109_CR93) 2013; 8 O Basturk (109_CR32) 2015; 39 AV Biankin (109_CR53) 2012; 491 JL Humphris (109_CR47) 2012; 23 S Weissmueller (109_CR68) 2014; 157 S Jones (109_CR51) 2012; 33 J Guinney (109_CR88) 2015; 21 AV Biankin (109_CR97) 2015; 28 B Vogelstein (109_CR92) 2013; 339 RR McWilliams (109_CR28) 2016; 45 A Scarpa (109_CR36) 2018; 67 CA Iacobuzio-Donahue (109_CR113) 2011; 61 AV Biankin (109_CR4) 2015; 526 JC Hall (109_CR117) 2016; 14 SA Forbes (109_CR80) 2011; 39 ST Kim (109_CR112) 2017; 8 NB Jamieson (109_CR91) 2015; 95 GM Petersen (109_CR14) 2016; 43 MJ Pishvaian (109_CR39) 2017; 31 DK Chang (109_CR74) 2014; 14 J Ledermann (109_CR66) 2012; 366 DP Ryan (109_CR11) 2014; 371 P Polak (109_CR77) 2017; 49 VP Balachandran (109_CR35) 2017; 551 LB Alexandrov (109_CR13) 2013; 500 J Humphris (109_CR24) 2015; 148 CJ Lord (109_CR75) 2012; 481 K Decker (109_CR90) 2006; 298 JB Candido (109_CR104) 2018; 23 K Shindo (109_CR23) 2017; 35 Y Jiao (109_CR116) 2014; 232 ZR Qian (109_CR49) 2018; 4 MI Canto (109_CR26) 2013; 62 KL Aung (109_CR122) 2017; 24 DJ Slamon (109_CR63) 2001; 344 O Basturk (109_CR31) 2014; 38 EMF Sousa De (109_CR86) 2013; 19 The Cancer Genome Atlas Research Network (109_CR60) 2017; 32 CA Iacobuzio-Donahue (109_CR45) 2009; 27 KA Brune (109_CR16) 2010; 102 JPt Morris (109_CR102) 2010; 120 BM Wolpin (109_CR19) 2009; 101 P Bailey (109_CR56) 2016; 531 L Marisa (109_CR87) 2013; 10 S Springer (109_CR37) 2015; 149 SB Dreyer (109_CR57) 2017; 23 JL Kopp (109_CR101) 2012; 22 EM Swisher (109_CR82) 2017; 18 CM Perou (109_CR84) 2000; 406 AA Connor (109_CR121) 2017; 3 |
| References_xml | – volume: 39 start-page: 1730 year: 2015 end-page: 1741 ident: CR32 article-title: A revised classification system and recommendations from the Baltimore Consensus Meeting for neoplastic precursor lesions in the pancreas publication-title: Am. J. Surg. Pathol. – volume: 101 start-page: 424 year: 2009 end-page: 431 ident: CR19 article-title: ABO blood group and the risk of pancreatic cancer publication-title: J. Natl Cancer Inst. – volume: 45 start-page: 311 year: 2016 end-page: 316 ident: CR28 article-title: Risk factors for early-onset and very-early-onset pancreatic adenocarcinoma: a pancreatic cancer case-control consortium (PanC4) analysis publication-title: Pancreas – volume: 8 start-page: 1096 year: 2018 end-page: 1111 ident: CR48 article-title: Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine publication-title: Cancer Discov. – volume: 28 start-page: 411 year: 2015 end-page: 413 ident: CR97 article-title: Subtyping pancreatic cancer publication-title: Cancer Cell – volume: 339 start-page: 1546 year: 2013 end-page: 1558 ident: CR92 article-title: Cancer genome landscapes publication-title: Science – volume: 3 start-page: 774 year: 2017 end-page: 783 ident: CR121 article-title: Association of distinct mutational signatures with correlates of increased immune activity in pancreatic ductal adenocarcinoma publication-title: JAMA Oncol. – volume: 29 start-page: 477 year: 2016 end-page: 493 ident: CR73 article-title: Activation mechanism of oncogenic deletion mutations in BRAF, EGFR, and HER2 publication-title: Cancer Cell – volume: 67 start-page: 7 year: 2017 end-page: 30 ident: CR8 article-title: Cancer statistics, 2017 publication-title: CA Cancer J. Clin. – volume: 137 start-page: 558 year: 2009 end-page: 568 ident: CR40 article-title: Expression of S100A2 calcium-binding protein predicts response to pancreatectomy for pancreatic cancer publication-title: Gastroenterology – volume: 344 start-page: 783 year: 2001 end-page: 792 ident: CR63 article-title: Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2 publication-title: N. Engl. J. Med. – volume: 17 start-page: 500 year: 2011 end-page: 503 ident: CR89 article-title: Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy publication-title: Nat. Med. – volume: 526 start-page: 361 year: 2015 end-page: 370 ident: CR4 article-title: Patient-centric trials for therapeutic development in precision oncology publication-title: Nature – volume: 14 year: 2016 ident: CR117 article-title: Novel patient-derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin publication-title: J. Transl Med. – volume: 26 start-page: 845 year: 2013 end-page: 851 ident: CR118 article-title: Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy publication-title: Pigment Cell Melanoma Res. – volume: 49 start-page: 1476 year: 2017 end-page: 1486 ident: CR77 article-title: A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer publication-title: Nat. Genet. – volume: 14 start-page: 955 year: 2017 end-page: 958 ident: CR107 article-title: Massively parallel single-nucleus RNA-seq with DroNc-seq publication-title: Nat. Methods – volume: 511 start-page: 543 year: 2014 end-page: 550 ident: CR12 article-title: Comprehensive molecular profiling of lung adenocarcinoma publication-title: Nature – volume: 3 start-page: 75ra26 year: 2011 ident: CR114 article-title: Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors publication-title: Sci. Transl Med. – volume: 20 start-page: 549 year: 2013 end-page: 556 ident: CR61 article-title: Understanding pancreatic cancer genomes publication-title: J. Hepatobiliary Pancreat. Sci. – volume: 35 start-page: 3382 year: 2017 end-page: 3390 ident: CR23 article-title: Deleterious germline mutations in patients with apparently sporadic pancreatic adenocarcinoma publication-title: J. Clin. Oncol. – volume: 5 year: 2015 ident: CR115 article-title: Whole exome sequencing reveals recurrent mutations in BRCA2 and FAT genes in acinar cell carcinomas of the pancreas publication-title: Sci. Rep. – volume: 14 start-page: 291 year: 2014 end-page: 292 ident: CR74 article-title: Mining the genomes of exceptional responders publication-title: Nat. Rev. Cancer – volume: 44 start-page: 1838 year: 2017 ident: CR46 article-title: Precision oncology in surgery: patient selection biomarkers for operable pancreatic cancer [abstract 10] publication-title: Eur. J. Surg. Oncol. – volume: 518 start-page: 495 year: 2015 end-page: 501 ident: CR55 article-title: Whole genomes redefine the mutational landscape of pancreatic cancer publication-title: Nature – volume: 33 start-page: 512 year: 2018 end-page: 526 ident: CR110 article-title: Loss of KDM6A activates super-enhancers to induce gender-specific squamous-like pancreatic cancer and confers sensitivity to BET inhibitors publication-title: Cancer Cell – volume: 531 start-page: 47 year: 2016 end-page: 52 ident: CR56 article-title: Genomic analyses identify molecular subtypes of pancreatic cancer publication-title: Nature – volume: 467 start-page: 596 year: 2010 end-page: 599 ident: CR64 article-title: Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma publication-title: Nature – volume: 18 start-page: 75 year: 2017 end-page: 87 ident: CR82 article-title: Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial publication-title: Lancet Oncol. – volume: 10 year: 2013 ident: CR87 article-title: Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value publication-title: PLOS Med. – volume: 2 start-page: 16022 year: 2016 ident: CR62 article-title: Pancreatic cancer publication-title: Nat. Rev. Dis. Primers – volume: 324 start-page: 217 year: 2009 ident: CR17 article-title: Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene publication-title: Science – volume: 77 start-page: 1868 year: 2017 end-page: 1879 ident: CR108 article-title: PanIN neuroendocrine cells promote tumorigenesis via neuronal cross-talk publication-title: Cancer Res. – volume: 500 start-page: 415 year: 2013 end-page: 421 ident: CR13 article-title: Signatures of mutational processes in human cancer publication-title: Nature – volume: 28 start-page: 248 year: 2015 end-page: 260 ident: CR120 article-title: Pancreatic undifferentiated rhabdoid carcinoma: KRAS alterations and SMARCB1 expression status define two subtypes publication-title: Mod. Pathol. – volume: 4 year: 2018 ident: CR49 article-title: Association of alterations in main driver genes with outcomes of patients with resected pancreatic ductal adenocarcinoma publication-title: JAMA Oncol. – volume: 157 start-page: 382 year: 2014 end-page: 394 ident: CR68 article-title: Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor beta signaling publication-title: Cell – volume: 130 start-page: 2762 year: 2017 end-page: 2773 ident: CR106 article-title: Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells publication-title: Blood – volume: 28 start-page: 977 year: 2004 end-page: 987 ident: CR33 article-title: An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms publication-title: Am. J. Surg. Pathol. – volume: 21 start-page: 1350 year: 2015 end-page: 1356 ident: CR88 article-title: The consensus molecular subtypes of colorectal cancer publication-title: Nat. Med. – volume: 120 start-page: 3669 year: 2014 end-page: 3675 ident: CR18 article-title: Clinical and pathologic features of familial pancreatic cancer publication-title: Cancer – ident: CR10 – volume: 64 start-page: 2634 year: 2004 end-page: 2638 ident: CR15 article-title: Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds publication-title: Cancer Res. – volume: 23 start-page: 1638 year: 2017 end-page: 1646 ident: CR57 article-title: Pancreatic cancer genomes: implications for clinical management and therapeutic development publication-title: Clin. Cancer Res. – volume: 18 start-page: 1307 year: 2017 end-page: 1316 ident: CR65 article-title: Dabrafenib plus trametinib in patients with previously untreated BRAF(V600E)-mutant metastatic non-small-cell lung cancer: an open-label, phase 2 trial publication-title: Lancet Oncol. – volume: 403 start-page: 503 year: 2000 end-page: 511 ident: CR83 article-title: Distinct types of diffuse large B cell lymphoma identified by gene expression profiling publication-title: Nature – volume: 148 start-page: 496 year: 2015 end-page: 498 ident: CR24 article-title: Inherited susceptibility to pancreatic cancer in the era of next-generation sequencing publication-title: Gastroenterology – volume: 29 start-page: 832 year: 2016 end-page: 845 ident: CR103 article-title: CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma publication-title: Cancer Cell – volume: 23 start-page: 517 year: 2017 end-page: 525 ident: CR78 article-title: HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures publication-title: Nat. Med. – volume: 14 start-page: 443 year: 2001 end-page: 451 ident: CR30 article-title: Adenosquamous carcinoma of the pancreas: a clinicopathologic series of 25 cases publication-title: Mod. Pathol. – volume: 152 start-page: 68 year: 2017 end-page: 74 ident: CR42 article-title: Hypermutation in pancreatic cancer publication-title: Gastroenterology – ident: CR123 – volume: 62 start-page: 339 year: 2013 end-page: 347 ident: CR26 article-title: International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer publication-title: Gut – volume: 8 year: 2013 ident: CR93 article-title: Somatic point mutation calling in low cellularity tumors publication-title: PLOS ONE – volume: 6 year: 2015 ident: CR59 article-title: Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets publication-title: Nat. Commun. – volume: 406 start-page: 747 year: 2000 end-page: 752 ident: CR84 article-title: Molecular portraits of human breast tumours publication-title: Nature – volume: 321 start-page: 1801 year: 2008 end-page: 1806 ident: CR52 article-title: Core signaling pathways in human pancreatic cancers revealed by global genomic analyses publication-title: Science – volume: 23 start-page: 1713 year: 2012 end-page: 1722 ident: CR47 article-title: The prognostic and predictive value of serum CA19.9 in pancreatic cancer publication-title: Ann. Oncol. – volume: 135 start-page: 1110 year: 2014 end-page: 1118 ident: CR95 article-title: Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling publication-title: Int. J. Cancer – volume: 58 start-page: 1410 year: 2009 end-page: 1418 ident: CR27 article-title: Five years of prospective screening of high-risk individuals from families with familial pancreatic cancer publication-title: Gut – volume: 16 start-page: 7773 year: 1988 end-page: 7782 ident: CR50 article-title: KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas publication-title: Nucleic Acids Res. – volume: 33 start-page: 100 year: 2012 end-page: 103 ident: CR51 article-title: Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types publication-title: Hum. Mut. – volume: 38 start-page: 437 year: 2014 end-page: 447 ident: CR31 article-title: Poorly differentiated neuroendocrine carcinomas of the pancreas: a clinicopathologic analysis of 44 cases publication-title: Am. J. Surg. Pathol. – ident: CR41 – volume: 351 start-page: 1218 year: 2004 end-page: 1226 ident: CR34 article-title: Cystic neoplasms of the pancreas publication-title: N. Engl. J. Med. – volume: 464 start-page: 993 year: 2010 end-page: 998 ident: CR1 article-title: International network of cancer genome projects publication-title: Nature – volume: 5 year: 2013 ident: CR70 article-title: Clinical and molecular characterization of HER2 amplified-pancreatic cancer publication-title: Genome Med. – volume: 32 start-page: 185 year: 2017 end-page: 203 ident: CR60 article-title: Integrated genomic characterization of pancreatic ductal adenocarcinoma publication-title: Cancer Cell – volume: 30 start-page: 1015 year: 2014 end-page: 1016 ident: CR43 article-title: MSIsensor: microsatellite instability detection using paired tumor-normal sequence data publication-title: Bioinformatics – year: 2018 ident: CR25 article-title: Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer publication-title: Genet. Med. doi: 10.1038/s41436-018-0009-5 – volume: 130 start-page: 79 year: 2011 end-page: 91 ident: CR3 article-title: Somatic variation and cancer: therapies lost in the mix publication-title: Hum. Genet. – volume: 67 start-page: 1561 year: 2018 end-page: 1563 ident: CR36 article-title: Genetic unrelatedness of co-occurring pancreatic adenocarcinomas and IPMNs challenges current views of clinical management publication-title: Gut – volume: 18 start-page: 338 year: 2015 end-page: 348 ident: CR5 article-title: The challenges of precision oncology drug development and implementation publication-title: Public Health Genomics – volume: 95 start-page: 919 year: 2015 end-page: 934 ident: CR91 article-title: Cancer genetics and implications for clinical management publication-title: Surg. Clin. North Am. – volume: 7 year: 2012 ident: CR94 article-title: qpure: a tool to estimate tumor cellularity from genome-wide single-nucleotide polymorphism profiles publication-title: PLOS ONE – volume: 63 start-page: 1481 year: 2014 end-page: 1489 ident: CR67 article-title: Targeting mTOR dependency in pancreatic cancer publication-title: Gut – volume: 27 start-page: 1806 year: 2009 end-page: 1813 ident: CR45 article-title: DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer publication-title: J. Clin. Oncol. – volume: 41 start-page: 2213 year: 2005 end-page: 2236 ident: CR44 article-title: Molecular prognostic markers in pancreatic cancer: a systematic review publication-title: Eur. J. Cancer – volume: 25 start-page: 1185 year: 2016 end-page: 1191 ident: CR21 article-title: Association of common susceptibility variants of pancreatic cancer in higher-risk patients: a PACGENE study publication-title: Cancer Epidemiol. Biomarkers Prev. – volume: 24 start-page: 1344 year: 2017 end-page: 1354 ident: CR122 article-title: Genomics-driven precision medicine for advanced pancreatic cancer — early results from the COMPASS trial publication-title: Clin. Cancer Res. – volume: 455 start-page: 1061 year: 2008 end-page: 1068 ident: CR2 article-title: Comprehensive genomic characterization defines human glioblastoma genes and core pathways publication-title: Nature – volume: 14 year: 2017 ident: CR111 article-title: Master regulators of oncogenic KRAS response in pancreatic cancer: an integrative network biology analysis publication-title: PLOS Med. – volume: 4 start-page: 1398 year: 2014 end-page: 1405 ident: CR71 article-title: Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes publication-title: Cancer Discov. – volume: 23 start-page: 1448 year: 2018 end-page: 1460 ident: CR104 article-title: CSF1R(+) macrophages sustain pancreatic tumor growth through T cell suppression and maintenance of key gene programs that define the squamous subtype publication-title: Cell Rep. – volume: 102 start-page: 119 year: 2010 end-page: 126 ident: CR16 article-title: Importance of age of onset in pancreatic cancer kindreds publication-title: J. Natl Cancer Inst. – volume: 43 start-page: 548 year: 2016 end-page: 553 ident: CR14 article-title: Familial pancreatic cancer publication-title: Semin. Oncol. – volume: 23 start-page: 6094 year: 2017 end-page: 6100 ident: CR72 article-title: Real-time genomic profiling of pancreatic ductal adenocarcinoma: potential actionability and correlation with clinical phenotype publication-title: Clin. Cancer Res. – volume: 227 start-page: 446 year: 2012 end-page: 455 ident: CR76 article-title: Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes publication-title: J. Pathol. – volume: 120 start-page: 508 year: 2010 end-page: 520 ident: CR102 article-title: Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice publication-title: J. Clin. Invest. – volume: 28 start-page: 607 year: 2015 end-page: 610 ident: CR119 article-title: Clinical activity of the MEK inhibitor trametinib in metastatic melanoma containing BRAF kinase fusion publication-title: Pigment Cell Melanoma Res. – ident: CR81 – volume: 366 start-page: 1382 year: 2012 end-page: 1392 ident: CR66 article-title: Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer publication-title: N. Engl. J. Med. – volume: 148 start-page: 556 year: 2014 end-page: 564 ident: CR22 article-title: Prevalence of germline mutations in cancer predisposition genes in patients with pancreatic cancer publication-title: Gastroenterology – volume: 7 start-page: 1063 year: 2015 end-page: 1076 ident: CR69 article-title: Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy publication-title: EMBO Mol. Med. – volume: 149 start-page: 1501 year: 2015 end-page: 1510 ident: CR37 article-title: A combination of molecular markers and clinical features improve the classification of pancreatic cysts publication-title: Gastroenterology – volume: 232 start-page: 428 year: 2014 end-page: 435 ident: CR116 article-title: Whole-exome sequencing of pancreatic neoplasms with acinar differentiation publication-title: J. Pathol. – volume: 551 start-page: 512 year: 2017 end-page: 516 ident: CR35 article-title: Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer publication-title: Nature – volume: 146 start-page: 233 year: 2014 end-page: 244 ident: CR109 article-title: Identification and manipulation of biliary metaplasia in pancreatic tumors publication-title: Gastroenterology – volume: 177 start-page: 2585 year: 2010 end-page: 2596 ident: CR105 article-title: Role of pancreatic stellate cells in pancreatic cancer metastasis publication-title: Am. J. Pathol. – volume: 22 start-page: 737 year: 2012 end-page: 750 ident: CR101 article-title: Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma publication-title: Cancer Cell – volume: 47 start-page: 1168 year: 2015 end-page: 1178 ident: CR58 article-title: Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma publication-title: Nat. Genet. – volume: 24 start-page: 74 year: 2014 end-page: 81 ident: CR54 article-title: Pancreatic cancer genomics publication-title: Curr. Opin. Genet. Dev. – volume: 19 start-page: 619 year: 2013 end-page: 625 ident: CR85 article-title: A colorectal cancer classification system that associates cellular phenotype and responses to therapy publication-title: Nat. Med. – volume: 24 start-page: 1326 year: 2018 end-page: 1336 ident: CR20 article-title: Evaluating mismatch repair deficiency in pancreatic adenocarcinoma: challenges and recommendations publication-title: Clin. Cancer Res. – volume: 298 start-page: 415 year: 2006 end-page: 429 ident: CR90 article-title: Gata6 is an important regulator of mouse pancreas development publication-title: Dev. Biol. – volume: 91 start-page: 355 year: 2004 end-page: 358 ident: CR79 article-title: The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website publication-title: Br. J. Cancer – volume: 481 start-page: 287 year: 2012 end-page: 294 ident: CR75 article-title: The DNA damage response and cancer therapy publication-title: Nature – volume: 27 start-page: 1443 year: 2016 end-page: 1448 ident: CR6 article-title: Consensus on precision medicine for metastatic cancers: a report from the MAP conference publication-title: Ann. Oncol. – volume: 371 start-page: 2140 year: 2014 end-page: 2141 ident: CR11 article-title: Pancreatic adenocarcinoma publication-title: N. Engl. J. Med. – volume: 107 start-page: 67 year: 2013 end-page: 77 ident: CR38 article-title: Histopathologic assessment of pancreatic cancer: does one size fit all? publication-title: J. Surg. Oncol. – volume: 19 start-page: 614 year: 2013 end-page: 618 ident: CR86 article-title: Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions publication-title: Nat. Med. – volume: 8 start-page: 77415 year: 2017 end-page: 77423 ident: CR112 article-title: Correlating programmed death ligand 1 (PD-L1) expression, mismatch repair deficiency, and outcomes across tumor types: implications for immunotherapy publication-title: Oncotarget – volume: 155 start-page: 1999 year: 2018 end-page: 2013 ident: CR98 article-title: Stratification of pancreatic ductal adenocarcinomas based on tumor and microenvironment features publication-title: Gastroenterology – volume: 491 start-page: 399 year: 2012 end-page: 405 ident: CR53 article-title: Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes publication-title: Nature – volume: 31 start-page: 159 year: 2017 end-page: 166 ident: CR39 article-title: Therapeutic implications of molecular subtyping for pancreatic cancer publication-title: Oncology – volume: 74 start-page: 2913 year: 2014 end-page: 2921 ident: CR9 article-title: Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States publication-title: Cancer Res. – ident: CR7 – volume: 22 start-page: 278 year: 2016 end-page: 287 ident: CR99 article-title: CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma publication-title: Nat. Med. – volume: 158 start-page: 929 year: 2014 end-page: 944 ident: CR96 article-title: Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin publication-title: Cell – volume: 39 start-page: D945 year: 2011 end-page: D950 ident: CR80 article-title: COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer publication-title: Nucleic Acids Res. – volume: 61 start-page: 1085 year: 2011 end-page: 1094 ident: CR113 article-title: Genetic evolution of pancreatic cancer: lessons learnt from the pancreatic cancer genome sequencing project publication-title: Gut – volume: 85 start-page: 219 year: 2001 end-page: 228 ident: CR29 article-title: WHO-classification 2000: exocrine pancreatic tumors publication-title: Verh. Dtsch. Ges. Pathol. – volume: 67 start-page: 508 year: 2017 end-page: 520 ident: CR100 article-title: Pancreatic cancer cell lines as patient-derived avatars: genetic characterisation and functional utility publication-title: Gut – volume: 85 start-page: 219 year: 2001 ident: 109_CR29 publication-title: Verh. Dtsch. Ges. Pathol. – volume: 7 start-page: 1063 year: 2015 ident: 109_CR69 publication-title: EMBO Mol. Med. doi: 10.15252/emmm.201404827 – volume: 19 start-page: 614 year: 2013 ident: 109_CR86 publication-title: Nat. Med. doi: 10.1038/nm.3174 – volume: 24 start-page: 74 year: 2014 ident: 109_CR54 publication-title: Curr. Opin. Genet. Dev. doi: 10.1016/j.gde.2013.12.001 – volume: 67 start-page: 508 year: 2017 ident: 109_CR100 publication-title: Gut doi: 10.1136/gutjnl-2016-313133 – ident: 109_CR123 doi: 10.1101/198903 – volume: 101 start-page: 424 year: 2009 ident: 109_CR19 publication-title: J. Natl Cancer Inst. doi: 10.1093/jnci/djp020 – volume: 18 start-page: 75 year: 2017 ident: 109_CR82 publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(16)30559-9 – volume: 62 start-page: 339 year: 2013 ident: 109_CR26 publication-title: Gut doi: 10.1136/gutjnl-2012-303108 – volume: 33 start-page: 512 year: 2018 ident: 109_CR110 publication-title: Cancer Cell doi: 10.1016/j.ccell.2018.02.003 – volume: 6 year: 2015 ident: 109_CR59 publication-title: Nat. Commun. doi: 10.1038/ncomms7744 – volume: 49 start-page: 1476 year: 2017 ident: 109_CR77 publication-title: Nat. Genet. doi: 10.1038/ng.3934 – volume: 35 start-page: 3382 year: 2017 ident: 109_CR23 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2017.72.3502 – volume: 531 start-page: 47 year: 2016 ident: 109_CR56 publication-title: Nature doi: 10.1038/nature16965 – volume: 47 start-page: 1168 year: 2015 ident: 109_CR58 publication-title: Nat. Genet. doi: 10.1038/ng.3398 – volume: 23 start-page: 6094 year: 2017 ident: 109_CR72 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-17-0899 – volume: 4 start-page: 1398 year: 2014 ident: 109_CR71 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-14-0617 – volume: 17 start-page: 500 year: 2011 ident: 109_CR89 publication-title: Nat. Med. doi: 10.1038/nm.2344 – volume: 77 start-page: 1868 year: 2017 ident: 109_CR108 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-16-0899 – volume: 137 start-page: 558 year: 2009 ident: 109_CR40 publication-title: Gastroenterology doi: 10.1053/j.gastro.2009.04.009 – volume: 91 start-page: 355 year: 2004 ident: 109_CR79 publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6601894 – volume: 148 start-page: 556 year: 2014 ident: 109_CR22 publication-title: Gastroenterology doi: 10.1053/j.gastro.2014.11.042 – volume: 10 year: 2013 ident: 109_CR87 publication-title: PLOS Med. doi: 10.1371/journal.pmed.1001453 – volume: 518 start-page: 495 year: 2015 ident: 109_CR55 publication-title: Nature doi: 10.1038/nature14169 – volume: 120 start-page: 508 year: 2010 ident: 109_CR102 publication-title: J. Clin. Invest. doi: 10.1172/JCI40045 – volume: 74 start-page: 2913 year: 2014 ident: 109_CR9 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-14-0155 – volume: 20 start-page: 549 year: 2013 ident: 109_CR61 publication-title: J. Hepatobiliary Pancreat. Sci. doi: 10.1007/s00534-013-0610-6 – volume: 23 start-page: 1638 year: 2017 ident: 109_CR57 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-16-2411 – volume: 23 start-page: 517 year: 2017 ident: 109_CR78 publication-title: Nat. Med. doi: 10.1038/nm.4292 – ident: 109_CR81 – volume: 406 start-page: 747 year: 2000 ident: 109_CR84 publication-title: Nature doi: 10.1038/35021093 – ident: 109_CR10 – volume: 27 start-page: 1443 year: 2016 ident: 109_CR6 publication-title: Ann. Oncol. doi: 10.1093/annonc/mdw192 – volume: 8 start-page: 1096 year: 2018 ident: 109_CR48 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-18-0275 – volume: 481 start-page: 287 year: 2012 ident: 109_CR75 publication-title: Nature doi: 10.1038/nature10760 – volume: 14 start-page: 291 year: 2014 ident: 109_CR74 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3723 – volume: 130 start-page: 2762 year: 2017 ident: 109_CR106 publication-title: Blood doi: 10.1182/blood-2017-08-803353 – volume: 39 start-page: 1730 year: 2015 ident: 109_CR32 publication-title: Am. J. Surg. Pathol. doi: 10.1097/PAS.0000000000000533 – volume: 44 start-page: 1838 year: 2017 ident: 109_CR46 publication-title: Eur. J. Surg. Oncol. doi: 10.1016/j.ejso.2018.10.024 – volume: 5 year: 2013 ident: 109_CR70 publication-title: Genome Med. doi: 10.1186/gm482 – volume: 455 start-page: 1061 year: 2008 ident: 109_CR2 publication-title: Nature doi: 10.1038/nature07385 – volume: 19 start-page: 619 year: 2013 ident: 109_CR85 publication-title: Nat. Med. doi: 10.1038/nm.3175 – volume: 8 start-page: 77415 year: 2017 ident: 109_CR112 publication-title: Oncotarget doi: 10.18632/oncotarget.20492 – volume: 146 start-page: 233 year: 2014 ident: 109_CR109 publication-title: Gastroenterology doi: 10.1053/j.gastro.2013.08.053 – volume: 28 start-page: 411 year: 2015 ident: 109_CR97 publication-title: Cancer Cell doi: 10.1016/j.ccell.2015.09.020 – volume: 24 start-page: 1344 year: 2017 ident: 109_CR122 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-17-2994 – volume: 23 start-page: 1713 year: 2012 ident: 109_CR47 publication-title: Ann. Oncol. doi: 10.1093/annonc/mdr561 – volume: 232 start-page: 428 year: 2014 ident: 109_CR116 publication-title: J. Pathol. doi: 10.1002/path.4310 – volume: 26 start-page: 845 year: 2013 ident: 109_CR118 publication-title: Pigment Cell Melanoma Res. doi: 10.1111/pcmr.12148 – volume: 29 start-page: 477 year: 2016 ident: 109_CR73 publication-title: Cancer Cell doi: 10.1016/j.ccell.2016.02.010 – volume: 227 start-page: 446 year: 2012 ident: 109_CR76 publication-title: J. Pathol. doi: 10.1002/path.4042 – volume: 25 start-page: 1185 year: 2016 ident: 109_CR21 publication-title: Cancer Epidemiol. Biomarkers Prev. doi: 10.1158/1055-9965.EPI-15-1217 – volume: 28 start-page: 248 year: 2015 ident: 109_CR120 publication-title: Mod. Pathol. doi: 10.1038/modpathol.2014.100 – volume: 39 start-page: D945 year: 2011 ident: 109_CR80 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq929 – volume: 8 year: 2013 ident: 109_CR93 publication-title: PLOS ONE doi: 10.1371/journal.pone.0074380 – volume: 43 start-page: 548 year: 2016 ident: 109_CR14 publication-title: Semin. Oncol. doi: 10.1053/j.seminoncol.2016.09.002 – volume: 41 start-page: 2213 year: 2005 ident: 109_CR44 publication-title: Eur. J. Cancer doi: 10.1016/j.ejca.2005.04.044 – volume: 18 start-page: 338 year: 2015 ident: 109_CR5 publication-title: Public Health Genomics doi: 10.1159/000441557 – volume: 63 start-page: 1481 year: 2014 ident: 109_CR67 publication-title: Gut doi: 10.1136/gutjnl-2013-306202 – ident: 109_CR41 – volume: 135 start-page: 1110 year: 2014 ident: 109_CR95 publication-title: Int. J. Cancer doi: 10.1002/ijc.28765 – volume: 371 start-page: 2140 year: 2014 ident: 109_CR11 publication-title: N. Engl. J. Med. – volume: 24 start-page: 1326 year: 2018 ident: 109_CR20 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-17-3099 – volume: 3 start-page: 774 year: 2017 ident: 109_CR121 publication-title: JAMA Oncol. doi: 10.1001/jamaoncol.2016.3916 – volume: 324 start-page: 217 year: 2009 ident: 109_CR17 publication-title: Science doi: 10.1126/science.1171202 – volume: 526 start-page: 361 year: 2015 ident: 109_CR4 publication-title: Nature doi: 10.1038/nature15819 – volume: 30 start-page: 1015 year: 2014 ident: 109_CR43 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt755 – volume: 5 year: 2015 ident: 109_CR115 publication-title: Sci. Rep. – volume: 500 start-page: 415 year: 2013 ident: 109_CR13 publication-title: Nature doi: 10.1038/nature12477 – volume: 32 start-page: 185 year: 2017 ident: 109_CR60 publication-title: Cancer Cell doi: 10.1016/j.ccell.2017.07.007 – volume: 14 year: 2016 ident: 109_CR117 publication-title: J. Transl Med. – volume: 298 start-page: 415 year: 2006 ident: 109_CR90 publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2006.06.046 – volume: 339 start-page: 1546 year: 2013 ident: 109_CR92 publication-title: Science doi: 10.1126/science.1235122 – volume: 22 start-page: 737 year: 2012 ident: 109_CR101 publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.10.025 – volume: 464 start-page: 993 year: 2010 ident: 109_CR1 publication-title: Nature doi: 10.1038/nature08987 – volume: 16 start-page: 7773 year: 1988 ident: 109_CR50 publication-title: Nucleic Acids Res. doi: 10.1093/nar/16.16.7773 – volume: 107 start-page: 67 year: 2013 ident: 109_CR38 publication-title: J. Surg. Oncol. doi: 10.1002/jso.23194 – volume: 14 start-page: 955 year: 2017 ident: 109_CR107 publication-title: Nat. Methods doi: 10.1038/nmeth.4407 – volume: 177 start-page: 2585 year: 2010 ident: 109_CR105 publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2010.090899 – volume: 511 start-page: 543 year: 2014 ident: 109_CR12 publication-title: Nature doi: 10.1038/nature13385 – volume: 351 start-page: 1218 year: 2004 ident: 109_CR34 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra031623 – volume: 3 start-page: 75ra26 year: 2011 ident: 109_CR114 publication-title: Sci. Transl Med. doi: 10.1126/scitranslmed.3002003 – volume: 45 start-page: 311 year: 2016 ident: 109_CR28 publication-title: Pancreas doi: 10.1097/MPA.0000000000000392 – volume: 61 start-page: 1085 year: 2011 ident: 109_CR113 publication-title: Gut doi: 10.1136/gut.2010.236026 – volume: 58 start-page: 1410 year: 2009 ident: 109_CR27 publication-title: Gut doi: 10.1136/gut.2008.171611 – volume: 155 start-page: 1999 year: 2018 ident: 109_CR98 publication-title: Gastroenterology doi: 10.1053/j.gastro.2018.08.033 – year: 2018 ident: 109_CR25 publication-title: Genet. Med. doi: 10.1038/s41436-018-0009-5 – volume: 366 start-page: 1382 year: 2012 ident: 109_CR66 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1105535 – volume: 38 start-page: 437 year: 2014 ident: 109_CR31 publication-title: Am. J. Surg. Pathol. doi: 10.1097/PAS.0000000000000169 – volume: 31 start-page: 159 year: 2017 ident: 109_CR39 publication-title: Oncology – volume: 22 start-page: 278 year: 2016 ident: 109_CR99 publication-title: Nat. Med. doi: 10.1038/nm.4038 – volume: 28 start-page: 607 year: 2015 ident: 109_CR119 publication-title: Pigment Cell Melanoma Res. doi: 10.1111/pcmr.12388 – volume: 14 start-page: 443 year: 2001 ident: 109_CR30 publication-title: Mod. Pathol. doi: 10.1038/modpathol.3880332 – volume: 120 start-page: 3669 year: 2014 ident: 109_CR18 publication-title: Cancer doi: 10.1002/cncr.28863 – volume: 14 year: 2017 ident: 109_CR111 publication-title: PLOS Med. doi: 10.1371/journal.pmed.1002223 – volume: 67 start-page: 7 year: 2017 ident: 109_CR8 publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21387 – volume: 130 start-page: 79 year: 2011 ident: 109_CR3 publication-title: Hum. Genet. doi: 10.1007/s00439-011-1010-0 – volume: 102 start-page: 119 year: 2010 ident: 109_CR16 publication-title: J. Natl Cancer Inst. doi: 10.1093/jnci/djp466 – volume: 28 start-page: 977 year: 2004 ident: 109_CR33 publication-title: Am. J. Surg. Pathol. doi: 10.1097/01.pas.0000126675.59108.80 – volume: 2 start-page: 16022 year: 2016 ident: 109_CR62 publication-title: Nat. Rev. Dis. Primers doi: 10.1038/nrdp.2016.22 – volume: 23 start-page: 1448 year: 2018 ident: 109_CR104 publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.03.131 – volume: 321 start-page: 1801 year: 2008 ident: 109_CR52 publication-title: Science doi: 10.1126/science.1164368 – volume: 551 start-page: 512 year: 2017 ident: 109_CR35 publication-title: Nature doi: 10.1038/nature24462 – volume: 95 start-page: 919 year: 2015 ident: 109_CR91 publication-title: Surg. Clin. North Am. doi: 10.1016/j.suc.2015.05.003 – volume: 4 year: 2018 ident: 109_CR49 publication-title: JAMA Oncol. – volume: 18 start-page: 1307 year: 2017 ident: 109_CR65 publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(17)30679-4 – volume: 491 start-page: 399 year: 2012 ident: 109_CR53 publication-title: Nature doi: 10.1038/nature11547 – volume: 158 start-page: 929 year: 2014 ident: 109_CR96 publication-title: Cell doi: 10.1016/j.cell.2014.06.049 – volume: 148 start-page: 496 year: 2015 ident: 109_CR24 publication-title: Gastroenterology doi: 10.1053/j.gastro.2015.01.009 – volume: 33 start-page: 100 year: 2012 ident: 109_CR51 publication-title: Hum. Mut. doi: 10.1002/humu.21633 – volume: 149 start-page: 1501 year: 2015 ident: 109_CR37 publication-title: Gastroenterology doi: 10.1053/j.gastro.2015.07.041 – volume: 64 start-page: 2634 year: 2004 ident: 109_CR15 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-03-3823 – volume: 157 start-page: 382 year: 2014 ident: 109_CR68 publication-title: Cell doi: 10.1016/j.cell.2014.01.066 – volume: 29 start-page: 832 year: 2016 ident: 109_CR103 publication-title: Cancer Cell doi: 10.1016/j.ccell.2016.04.014 – volume: 403 start-page: 503 year: 2000 ident: 109_CR83 publication-title: Nature doi: 10.1038/35000501 – volume: 152 start-page: 68 year: 2017 ident: 109_CR42 publication-title: Gastroenterology doi: 10.1053/j.gastro.2016.09.060 – volume: 27 start-page: 1806 year: 2009 ident: 109_CR45 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2008.17.7188 – volume: 21 start-page: 1350 year: 2015 ident: 109_CR88 publication-title: Nat. Med. doi: 10.1038/nm.3967 – volume: 344 start-page: 783 year: 2001 ident: 109_CR63 publication-title: N. Engl. J. Med. doi: 10.1056/NEJM200103153441101 – volume: 67 start-page: 1561 year: 2018 ident: 109_CR36 publication-title: Gut doi: 10.1136/gutjnl-2018-316151 – volume: 7 year: 2012 ident: 109_CR94 publication-title: PLOS ONE – volume: 467 start-page: 596 year: 2010 ident: 109_CR64 publication-title: Nature doi: 10.1038/nature09454 – ident: 109_CR7 |
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| Title | Molecular subtypes of pancreatic cancer |
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