Association of genetic variation in the transforming growth factor beta-1 gene with serum levels and risk of colorectal neoplasia

In the normal intestinal epithelium transforming growth factor beta-1 (TGFbeta-1) acts as a growth inhibitor, but in malignant cells it may act as a tumor promoter. However, only limited information is available on genetic variation in the TGFB1 gene and its relationship to circulating levels and ri...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Jg. 68; H. 4; S. 1236
Hauptverfasser:	Saltzman, Barbara S, Yamamoto, Jennifer F, Decker, Robert, Yokochi, Lance, Theriault, Andre G, Vogt, Thomas M, Le Marchand, Loïc
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.02.2008
Schlagworte:	Adenocarcinoma - blood Adenocarcinoma - genetics Aged Aged, 80 and over Case-Control Studies Colorectal Neoplasms - blood Colorectal Neoplasms - genetics Female Genetic Predisposition to Disease Genetic Variation Haplotypes Humans Male Middle Aged Polymorphism, Single Nucleotide Transforming Growth Factor beta1 - blood Transforming Growth Factor beta1 - genetics
ISSN:	1538-7445, 1538-7445
Online-Zugang:	Weitere Angaben
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