A Novel Small Molecule Neurotrophin-3 Analogue Promotes Inner Ear Neurite Outgrowth and Synaptogenesis In vitro

Sensorineural hearing loss is irreversible and is associated with the loss of spiral ganglion neurons (SGNs) and sensory hair cells within the inner ear. Improving spiral ganglion neuron (SGN) survival, neurite outgrowth, and synaptogenesis could lead to significant gains for hearing-impaired patien...

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Bibliographic Details
Published in:	Frontiers in cellular neuroscience Vol. 15; p. 666706
Main Authors:	Kempfle, Judith S., Duro, Marlon V., Zhang, Andrea, Amador, Carolina D., Kuang, Richard, Lu, Ryan, Kashemirov, Boris A., Edge, Albert S., McKenna, Charles E., Jung, David H.
Format:	Journal Article
Language:	English
Published:	Lausanne Frontiers Research Foundation 15.07.2021 Frontiers Media S.A
Subjects:	Acids Axonogenesis bisphosphonate Bisphosphonates Bone matrix Brain-derived neurotrophic factor Cellular Neuroscience Cochlea Hair cells Hearing loss Hydroxyapatite Inner ear Neurotrophic factors Neurotrophin 3 Noise Proteins Regeneration Risedronic acid Sensory neurons small molecule Spiral ganglion Synaptogenesis synaptopathy
ISSN:	1662-5102, 1662-5102
Online Access:	Get full text
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