The disposition of intramuscular artemether in children with cerebral malaria; a preliminary study

The disposition of intramuscular artemether (AM) was studied in 26 Kenyan children with cerebral malaria. Antimalarial activity determined by bioassay was compared with total plasma AM plus dihydroartemisinin (DHA) determined by high power liquid chromatography (HPLC). Therapeutic levels were achiev...

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Bibliographic Details
Published in:	Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 91; no. 3; p. 331
Main Authors:	Murphy, S A, Mberu, E, Muhia, D, English, M, Crawley, J, Waruiru, C, Lowe, B, Newton, C R, Winstanley, P, Marsh, K, Watkins, W M
Format:	Journal Article
Language:	English
Published:	England 01.05.1997
Subjects:	Antimalarials - administration & dosage Antimalarials - blood Antimalarials - pharmacokinetics Artemether Artemisinins Biological Availability Child Child, Preschool Chromatography, High Pressure Liquid Female Humans Infant Injections, Intramuscular Kenya Malaria, Cerebral - blood Malaria, Cerebral - drug therapy Male Respiratory Insufficiency - complications Sesquiterpenes - administration & dosage Sesquiterpenes - blood Sesquiterpenes - pharmacokinetics Time Factors Treatment Outcome
ISSN:	0035-9203
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