Diversity of the lysozyme fold: structure of the catalytic domain from an unusual endolysin encoded by phage Enc34

Endolysins are bacteriophage-encoded peptidoglycan-degrading enzymes with potential applications for treatment of multidrug-resistant bacterial infections. Hafnia phage Enc34 encodes an unusual endolysin with an N-terminal enzymatically active domain and a C-terminal transmembrane domain. The cataly...

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Bibliographic Details
Published in:	Scientific reports Vol. 12; no. 1; pp. 5005 - 11
Main Authors:	Cernooka, Elina, Rumnieks, Janis, Zrelovs, Nikita, Tars, Kaspars, Kazaks, Andris
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23.03.2022 Nature Publishing Group Nature Portfolio
Subjects:	631/337 631/535 Bacteria Bacterial diseases Bacteriophages - metabolism Catalytic Domain Conserved sequence Crystal structure Endopeptidases - metabolism Enzymes Glycoside hydrolase Gram-negative bacteria Humanities and Social Sciences Lysozyme multidisciplinary Multidrug resistance Muramidase - metabolism Opportunist infection Peptidoglycan - metabolism Peptidoglycans Phages Science Science (multidisciplinary) Turbidity
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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