The antioxidant and anti-inflammatory activities of avasopasem manganese in age-associated, cisplatin-induced renal injury

Cisplatin contributes to acute kidney injury (AKI) and chronic kidney disease (CKD) that occurs with greater frequency and severity in older patients. Age-associated cisplatin sensitivity in human fibroblasts involves increased mitochondrial superoxide produced by older donor cells. Young and old C5...

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Bibliographic Details
Published in:	Redox biology Vol. 70; p. 103022
Main Authors:	Mapuskar, Kranti A., Pulliam, Casey F., Tomanek-Chalkley, Ann, Rastogi, Prerna, Wen, Hsiang, Dayal, Sanjana, Griffin, Benjamin R., Zepeda-Orozco, Diana, Sindler, Amy L., Anderson, Carryn M., Beardsley, Robert, Kennedy, Eugene P., Spitz, Douglas R., Allen, Bryan G.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.04.2024 Elsevier
Subjects:	Acute kidney injury (AKI) Acute Kidney Injury - chemically induced Acute Kidney Injury - drug therapy Aged Animals Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology Antioxidants - therapeutic use Avasopasem manganese Chronic kidney disease (CKD) Cisplatin Cisplatin - pharmacology Humans Kidney Mice Mice, Inbred C57BL Organometallic Compounds Renal Insufficiency, Chronic Superoxide dismutase mimetic Superoxides Avasopasem manganese Superoxide dismutase mimetic Chronic kidney disease (CKD) Cisplatin Acute kidney injury (AKI)
ISSN:	2213-2317, 2213-2317
Online Access:	Get full text
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