EMDR versus waiting list in individuals at clinical high risk for psychosis with post-traumatic stress symptoms: A randomized controlled trial

Post-traumatic stress disorder (PTSD) is highly prevalent in the individuals at clinical-high risk for psychosis (CHR). The aim of this study was to examine the efficacy and safety of Eye Movement Desensitization and Reprocessing (EMDR) in individuals at CHR with comorbid PTSD or subthreshold PTSD i...

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Veröffentlicht in:	Schizophrenia research Jg. 256; S. 1 - 7
Hauptverfasser:	Zhao, Jie, Chen, Dong-Yang, Li, Xian-Bin, Xi, Ying-Jun, Verma, Swapna, Zhou, Fu-Chun, Wang, Chuan-Yue
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.06.2023
Schlagworte:	Attenuated positive symptom syndrome CHR Eye Movement Desensitization and Reprocessing Eye Movement Desensitization Reprocessing - methods Humans Psychiatric/Mental Health Psychotic Disorders - therapy PTSD RCT Single-Blind Method Stress Disorders, Post-Traumatic - therapy Treatment Outcome Waiting Lists PTSD RCT Eye Movement Desensitization and Reprocessing CHR Attenuated positive symptom syndrome Clinical-high risk for psychosis Post-traumatic stress disorder Randomized controlled trial
ISSN:	0920-9964, 1573-2509, 1573-2509
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Zusammenfassung:	Post-traumatic stress disorder (PTSD) is highly prevalent in the individuals at clinical-high risk for psychosis (CHR). The aim of this study was to examine the efficacy and safety of Eye Movement Desensitization and Reprocessing (EMDR) in individuals at CHR with comorbid PTSD or subthreshold PTSD in a randomized controlled trial. Fifty-seven individuals at CHR with PTSD or subthreshold PTSD formed the study sample. The eligible participants were randomly assigned to a 12 weeks EMDR treatment (N = 28) or a waiting list condition (WL, N = 29). The structured interview for psychosis risk syndrome (SIPS), the clinician administered post-traumatic stress disorder scale (CAPS) and a battery of self-rating inventories covering depressive, anxiety and suicidal symptoms were administered. Twenty-six participants in the EMDR group and all the participants in the WL group completed the study. The analyses of covariance revealed greater reduction of the mean scores on CAPS (F = 23.2, Partial η2 = 0.3, P < 0.001), SIPS positive scales (F = 17.8, Partial η2 = 0.25, P < 0.001) and all the self-rating inventories in the EMDR group than in the WL group. Participants in the EMDR group were more likely to achieve remission of CHR compared to those in the WL group at endpoint (60.7 % vs. 31 %, P = 0.025). EMDR treatment not only effectively improved traumatic symptoms, but also significantly reduced the attenuated psychotic symptoms and resulted in a higher remission rate of CHR. This study highlighted the necessity of adding a trauma-focused component to the present approach of early intervention in psychosis.
Bibliographie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
ISSN:	0920-9964 1573-2509 1573-2509
DOI:	10.1016/j.schres.2023.04.003