A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing

The experimental need to engineer the genome both in time and space, has led to the development of several photoactivatable Cre recombinase systems. However, the combination of inefficient and non-intentional background recombination has prevented thus far the wide application of these systems in bi...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 6442 - 15
Main Authors:	Vizoso, Miguel, E. J. Pritchard, Colin, Bombardelli, Lorenzo, van den Broek, Bram, Krimpenfort, Paul, Beijersbergen, Roderick L., Jalink, Kees, van Rheenen, Jacco
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 28.10.2022 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/106 13/107 13/109 13/31 13/44 13/51 14 14/1 14/19 14/69 38 59 631/1647/2253 631/1647/334/1874/345 631/61/17/1511 631/67/2321 64 64/60 Animals Antibiotics Biomedical engineering Biomedical materials Biomedical research Cre recombinase Dermis Doxycycline Doxycycline - pharmacology Editing Engineers Gene Editing Gene expression Genome editing Genomes Humanities and Social Sciences Integrases - genetics Integrases - metabolism Medical research Mice Mice, Inbred Strains Mice, Transgenic multidisciplinary Mutagenesis Optogenetics Organoids Recombination Science Science (multidisciplinary) Tracing
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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