Rational design of a SOCS1-edited tumor-infiltrating lymphocyte therapy using CRISPR/Cas9 screens

Cell therapies such as tumor-infiltrating lymphocyte (TIL) therapy have shown promise in the treatment of patients with refractory solid tumors, with improvement in response rates and durability of responses nevertheless sought. To identify targets capable of enhancing the antitumor activity of T ce...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 133; no. 24; pp. 1 - 17
Main Authors:	Schlabach, Michael R., Lin, Sharon, Collester, Zachary R., Wrocklage, Christopher, Shenker, Sol, Calnan, Conor, Xu, Tianlei, Gannon, Hugh S., Williams, Leila J., Thompson, Frank, Dunbar, Paul R., LaMothe, Robert A., Garrett, Tracy E., Colletti, Nicholas, Hohmann, Anja F., Tubo, Noah J., Bullock, Caroline P., Le Mercier, Isabelle, Sofjan, Katri, Merkin, Jason J., Keegan, Sean, Kryukov, Gregory V., Dugopolski, Caroline, Stegmeier, Frank, Wong, Karrie, Sharp, Fiona A., Cadzow, Louise, Benson, Micah J.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 15.12.2023
Subjects:	Animal models Antitumor activity Biomedical research CD8 antigen Cell culture Cells CRISPR Cytokines Genes Immunological memory Immunology Lymphocytes Lymphocytes T Melanoma Memory cells Metastasis Progenitor cells Solid tumors Therapeutics Tumors Immunology Cancer immunotherapy Gene therapy T cells Therapeutics
ISSN:	1558-8238, 0021-9738, 1558-8238
Online Access:	Get full text
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