Capparis spinosa leaves extract: Source of bioantioxidants with nephroprotective and hepatoprotective effects

Capparis spinosa, Capparidaceae, is largely distributed all over the Mediterranean Basin and is traditionally used to treat many illnesses, such as liver and kidney diseases. The aim of the current study was to explore the antioxidant, nephroprotective and hepatoprotective effects of methanolic extr...

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Veröffentlicht in:Biomedicine & pharmacotherapy Jg. 87; S. 171 - 179
Hauptverfasser: Tlili, Nizar, Feriani, Anouar, Saadoui, Ezzeddine, Nasri, Nizar, Khaldi, Abdelhamid
Format: Journal Article
Sprache:Englisch
Veröffentlicht: France Elsevier Masson SAS 01.03.2017
Schlagworte:
Animals
Antioxidant
Antioxidants - isolation & purification
Antioxidants - pharmacology
Capparis
Capparis spinosa
Hepatoprotective
Internal Medicine
Kidney - drug effects
Kidney - metabolism
Kidney - pathology
Lipid Peroxidation - drug effects
Lipid Peroxidation - physiology
Liver - drug effects
Liver - metabolism
Liver - pathology
Male
Medical Education
Nephroprotective
Phytochemical
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Leaves
Protective Agents - isolation & purification
Protective Agents - pharmacology
Rats
Capparis spinosa
Nephroprotective
Hepatoprotective
Antioxidant
Phytochemical
ISSN:0753-3322, 1950-6007, 1950-6007
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Zusammenfassung:Capparis spinosa, Capparidaceae, is largely distributed all over the Mediterranean Basin and is traditionally used to treat many illnesses, such as liver and kidney diseases. The aim of the current study was to explore the antioxidant, nephroprotective and hepatoprotective effects of methanolic extract of Capparis spinosa leaves (MECS) associated with its phytochemical content. The levels of total phenolics, flavonoids and condensed tannins were 23.37mgGAE/g, 9.05mgQE/g and 9.35mgTAE/g, respectively. HPLC analysis revealed nine compounds, namely rutin, resveratrol, coumarin, epicatechin, luteolin, catechin, kaempferol, vanillic acid and gallic acid. The MECS showed interesting antioxidant capacity. The MECS-treatment significantly reduced the increased plasma levels of creatinine, urea and uric acid, reduced the elevated MDA levels, significantly reduced the antioxidant enzyme activities and restored the kidney damage, provoked by cisplatin-treatment. Furthermore, MECS-treatment significantly prevented the increase in serum ALT, AST and LDH levels in acute liver damage induced by CCl4, decreased the amount of hepatic malondialdehyde (MDA) formation and elevated the activities of SOD, CAT and GPx, and restored liver injury. This study supports the traditionally use of C. spinosa to cure kidney and liver diseases. The obtained results highlighted the possible use of C. spinosa as a source of phytochemical with important biological advantages.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0753-3322
1950-6007
1950-6007
DOI:10.1016/j.biopha.2016.12.052